minimal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7537	Norgestimate		Progesterone Receptor
	Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive.		Progesterone Receptor
T2324	Darunavir	TMC114	HIV Protease
	Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other AN...		HIV Protease
T5500	DORA-22		OX Receptor
	DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory		OX Receptor
T13721	Homo-PROTAC cereblon degrader 1		Others , Ligand for E3 Ligase
	Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.		Others , Ligand for E3 Ligase
T6187	TDZD-8	GSK-3β Inhibitor I,NP 01139	GSK-3
	TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.		GSK-3
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
T73040	CYP1B1-IN-4		P450
	CYP1B1-IN-4, a 2,4-diarylthiazole compound, exhibits selective inhibition of CYP1B1 (IC50=0.2 nM), demonstrating minimal cytotoxicity and high stability in human and rat liver microsomes [1].		P450
T9698	UC2288		Mdm2 , p53
	UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.		Mdm2 , p53
T61518	TAK-653		iGluR
	TAK-653, a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models.		iGluR
T11211	EP4 receptor antagonist 1		Prostaglandin Receptor
	EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and...		Prostaglandin Receptor
T4664	ML 297	ML297	Potassium Channel
	ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, an...		Potassium Channel
TP1760L	AMARA peptide acetate(163560-19-8 free base)		Others
	AMARA peptide acetate is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK)...		Others
T6029	ONX-0914	ONX0914,PR-957,ONX 0914	Proteasome , HIV Protease , Antibacterial
	ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.		Proteasome , HIV Protease , Antibacterial
T13102	TCMDC-135051		Others
	TCMDC-135051 is a potent and selective PfCLK3 protein kinase inhibitor demonstrating significant antiparasiticidal activity (EC50=320 nM) while exhibiting minimal off-target toxicity. It effectively hinders the transitio...		Others
T2534	Pitavastatin calcium	P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104	Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T6194	Fidaxomicin	Tiacumicin B,OPT-80,Clostomicin B1,PAR-101	Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme el...		Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic
T17197	UCL 2077
	UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker，with IC50 of 500 nM in hippocampal neurons in culture, having minima...
T15410	GNF351		Aryl Hydrocarbon Receptor
	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes wit...		Aryl Hydrocarbon Receptor
T15576	Indibulin	ZIO 301,D 24851	Apoptosis , Microtubule Associated
	Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu...		Apoptosis , Microtubule Associated