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Search Result

Search Results for " methylation "

Targets

MEK Histone Methyltransferase

67

Compounds

13

Natural Products

60

Recombinant Proteins

4

Libraries

Cat No. Product Name Synonyms Targets
T36631 BAY-6035 MEK , Histone Methyltransferase
BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
T6879 LLY-507 LLY507,LLY 507 Histone Methyltransferase
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
T1923 BRD4770 Histone Methyltransferase
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.
T13748 L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium Histone Demethylase , Mitochondrial Metabolism
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ...
T17212 VAL-083 Dianhydrogalactitol,Dianhydrodulcitol DNA Alkylator/Crosslinker , DNA Alkylation
VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T28996 TP-064 TP 064 Histone Methyltransferase
TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epig...
T23284 Ryuvidine Histone Demethylase , Histone Methyltransferase , CDK
Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and inhibition of CDK4, and can be used to study breast cancer ...
T16886 Sinefungin Adenosyl-Ornithine,A-9145,Antibiotic 32232RP Others , Histone Methyltransferase , Antibiotic , Antifungal
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r...
T9626 Cycloleucine NMDAR
Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef...
T6163 Salirasib Farnesyl Thiosalicylic Acid,S-Farnesylthiosalicylic acid,FTS Autophagy , Ras
Salirasib (Farnesyl Thiosalicylic Acid)(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic activity.
T9573 GSK3685032 DNA Methyltransferase
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c...
T2169 Zebularine NSC309132,4-Deoxyuridine DNA Methyltransferase , Autophagy
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2...
T1488 Procarbazine hydrochloride NSC-77213 HCl,Procarbazine HCl DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba...
T1613 Hydralazine hydrochloride Hydralazine HCl,Apresoline MAO , HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...
T27453 GSK1733953A DG70 Antibacterial
GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 μM.GSK1733953A is a selective biphenylbenzamide with ...
T22297 Clindamycin hydrochloride monohydrate Clindamycin alcoholate Antibiotic
Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentra...
T77697 BML-278 BML278,BML 278 Sirtuin , Histone Methyltransferase
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...
T69703 BAY-6035-R-isomer
BAY-6035 is an inhibitor of the methylation of MEKK2 peptide.
T40713 Dihydro-5-azacytidine DHAC,NSC264880,Dihydro-5-azacytidine
Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
T15169 DS-437 Others
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
T82088 ICMT-IN-54
ICMT-IN-54 (compound 7c), an adamantyl analogue, serves as an ICMT inhibitor with an IC50 value of 12.4 μM, targeting the methylation process facilitated by ICMT. It specifically inhibits the methylation of BFC (N-biotin...
T69321 LX-3
LX-3 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway, which de-represses a subset of endogenous genes repressed by DNA methylation.
T40776 Diguanosine 5′-triphosphate Diguanosine 5′-triphosphate,Gp3G
Diguanosine 5′-triphosphate (Gp3G) is a kind of homodinucleotide from by GTP:GTP guanylyltransferase. Diguanosine 5′-triphosphate is a virus-specific oligonucleotide, can be used to prime reovirus transcription and inhib...
T78565 Dihydro-5-azacytidine acetate DHAC acetate,NSC 264880 acetate Nucleoside Antimetabolite/Analog
Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1] [2].
T69412 LX-4
LX-4 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-4 de-represses a subset of endogenous genes repressed by DNA methylation.
T39144 3,4,5-Trichloroveratrole
3,4,5-Trichloroveratrole is a chemical compound that is produced through bacterial O-methylation of Tri- and Tetra chloroguaiacols. These chloroguaiacols are generated during bleaching wood pulp in the paper manufacturin...
T41098 Tetrachloroveratrole
Tetrachloroveratrole, a byproduct of bacterial O-methylation, arises from the biodegradation of Tri- and Tetra chloroguaiacols. These chloroguaiacols emerge as a result of the wood pulp bleaching process within the paper...
T21097 Decamethyltetrasiloxane Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780
Decamethyltetrasiloxane, a non-cyclic silicone oligomer, is used in the methylation of mercury(II) salts. It is transformed by a specific microflora. In the natural environment, it is degraded by mechanisms similar to ot...
T69333 LX-5
LX-5 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-5 de-represses a subset of endogenous genes repressed by DNA methylation.
T29651 Ademetionine, (S)-
Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phosphol...
T35764 S-Farnesyl Thioacetic Acid
S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can ...
T39580 Histone H3 (23-34) Histone H3 (23-34)
Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylati...
T38785 Histone H3 (21-44) Histone H3 (21-44)
Histone H3 (21-44), derived from a sequence of 21-44 amino acids of histone H3, is commonly employed as a substrate, particularly for protein arginine methyltransferase assays, where methylation activity is being examine...
T80632 Methyl 3,4-dimethoxycinnamate
Methyl 3,4-dimethoxycinnamate impedes uredospore germination and concurrently inhibits global DNA methylation in Hep3B cells [1] [2].
T37693 N-acetyl-S-geranylgeranyl-L-Cysteine
N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate f...
T69922 EPZ020411 HCl
EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 argin...
T63783 AZ506
AZ506 is a potent inhibitor of SMYD2 (IC50: 17 nM). AZ506 inhibits SMYD2 methyltransferase activity in cells and reduces SMYD2-mediated methylation signaling.
T69937 INCB059872 tosylate
INCB059872, also known as INCB59872, is a potent, selective, and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target gene...
T11751 KDOAM-25 Antibacterial
KDOAM-25, a potent and highly selective inhibitor of histone lysine demethylases 5 (KDM5) with IC50 values of 71 nM for KDM5A, 19 nM for KDM5B, 69 nM for KDM5C, and 69 nM for KDM5D, enhances global H3K4 methylation at tr...
T39648 (R)-GSK-3685032
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC 50 of 0.036 μM. GSK-3685032 induces robust loss of D...
T75239 C-Myc inhibitor 10
C-Myc Inhibitor 10 (compound 17), exhibiting enhanced cellular potency, benefits from increased permeability due to the methylation of the morpholine nitrogen [1].
T36576 Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44...
T11750L KDOAM-25 trihydrochloride (2230731-99-2 free base) KDOAM-25 trihydrochloride Others
KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 trihydrochloride is a potent and highly selective histone lysi...
T37373 4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermedi...
T21756 Bizine
Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>K i of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine has potential applications in neuroprotective [1].
T70008 Bomedemstat ditosylate
Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndro...
T60544 HPV18-IN-1
HPV18-IN-1 (Compound H1) is a potent HPV18 inhibitor that prevents cervical cancer cells from premature cell procession and abnormal proliferation. HPV18-IN-1 supresses E7-Rb-E2F cellular pathway and DNA methylation with...
T39800 S2116
S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing recipr...
T39799 S2157 S2157
S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound tri...
T35543 Methyl Diethyldithiocarbamate
Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Meth...

Compounds

BAY-6035
T36631
Synonym:
Target: MEK, Histone Methyltransferase
LLY-507
T6879
Synonym: LLY507,LLY 507
Target: Histone Methyltransferase
BRD4770
T1923
Synonym:
Target: Histone Methyltransferase
L-2-Hydroxyglutaric acid disodium
T13748
Synonym: (S)-2-Hydroxyglutaric acid disodium
Target: Histone Demethylase, Mitochondrial Metabolism
VAL-083
T17212
Synonym: Dianhydrogalactitol,Dianhydrodulcitol
Target: DNA Alkylator/Crosslinker, DNA Alkylation
TP-064
T28996
Synonym: TP 064
Target: Histone Methyltransferase
Ryuvidine
T23284
Synonym:
Target: Histone Demethylase, Histone Methyltransferase, CDK
Sinefungin
T16886
Synonym: Adenosyl-Ornithine,A-9145,Antibiotic 32232RP
Target: Others, Histone Methyltransferase, Antibiotic, Antifungal
Cycloleucine
T9626
Synonym:
Target: NMDAR
Salirasib
T6163
Synonym: Farnesyl Thiosalicylic Acid,S-Farnesylthiosalicylic acid,FTS
Target: Autophagy, Ras
GSK3685032
T9573
Synonym:
Target: DNA Methyltransferase
Zebularine
T2169
Synonym: NSC309132,4-Deoxyuridine
Target: DNA Methyltransferase, Autophagy
Procarbazine hydrochloride
T1488
Synonym: NSC-77213 HCl,Procarbazine HCl
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Hydralazine hydrochloride
T1613
Synonym: Hydralazine HCl,Apresoline
Target: MAO, HIF/HIF Prolyl-Hydroxylase
GSK1733953A
T27453
Synonym: DG70
Target: Antibacterial
Clindamycin hydrochloride monohydrate
T22297
Synonym: Clindamycin alcoholate
Target: Antibiotic
BML-278
T77697
Synonym: BML278,BML 278
Target: Sirtuin, Histone Methyltransferase
BAY-6035-R-isomer
T69703
Synonym:
Target:
Dihydro-5-azacytidine
T40713
Synonym: DHAC,NSC264880,Dihydro-5-azacytidine
Target:
DS-437
T15169
Synonym:
Target: Others
ICMT-IN-54
T82088
Synonym:
Target:
LX-3
T69321
Synonym:
Target:
Diguanosine 5′-triphosphate
T40776
Synonym: Diguanosine 5′-triphosphate,Gp3G
Target:
Dihydro-5-azacytidine acetate
T78565
Synonym: DHAC acetate,NSC 264880 acetate
Target: Nucleoside Antimetabolite/Analog
LX-4
T69412
Synonym:
Target:
3,4,5-Trichloroveratrole
T39144
Synonym:
Target:
Tetrachloroveratrole
T41098
Synonym:
Target:
Decamethyltetrasiloxane
T21097
Synonym: Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780
Target:
LX-5
T69333
Synonym:
Target:
Ademetionine, (S)-
T29651
Synonym:
Target:
S-Farnesyl Thioacetic Acid
T35764
Synonym:
Target:
Histone H3 (23-34)
T39580
Synonym: Histone H3 (23-34)
Target:
Histone H3 (21-44)
T38785
Synonym: Histone H3 (21-44)
Target:
Methyl 3,4-dimethoxycinnamate
T80632
Synonym:
Target:
N-acetyl-S-geranylgeranyl-L-Cysteine
T37693
Synonym:
Target:
EPZ020411 HCl
T69922
Synonym:
Target:
AZ506
T63783
Synonym:
Target:
INCB059872 tosylate
T69937
Synonym:
Target:
KDOAM-25
T11751
Synonym:
Target: Antibacterial
(R)-GSK-3685032
T39648
Synonym:
Target:
c-Myc inhibitor 10
T75239
Synonym:
Target:
Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
T36576
Synonym: Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
Target:
KDOAM-25 trihydrochloride (2230731-99-2 free base)
T11750L
Synonym: KDOAM-25 trihydrochloride
Target: Others
4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
T37373
Synonym:
Target:
Bizine
T21756
Synonym:
Target:
Bomedemstat ditosylate
T70008
Synonym:
Target:
HPV18-IN-1
T60544
Synonym:
Target:
S2116
T39800
Synonym:
Target:
S2157
T39799
Synonym: S2157
Target:
Methyl Diethyldithiocarbamate
T35543
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T1339 5-Azacytidine Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-AzaC Nucleoside Antimetabolite/Analog , DNA Methyltransferase , Antibacterial , Antibiotic , Autophagy
5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autopha...
T5270 5-Methylcytosine Others , DNA/RNA Synthesis , Endogenous Metabolite
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. In animals, the DNA methylation of cytosine to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In plants, the methylated...
T3881 Vaccarin Integrin , Akt , PERK , AMPK
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.
T5233 N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide Others , Endogenous Metabolite
N-Methylnicotinamide (Nicotinic Acid Methylamide) is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-Methylnicotinamide (Nicotinic Acid Methylam...
T0069 Uracil Others , Endogenous Metabolite
Uracil is a common naturally occurring pyrimidine found in RNA, it base pairs with adenine and is replaced by thymine in DNA. Methylation of uracil produces thymine. Uracil's use in the body is to help carry out the synt...
T1507 Streptozocin STZ,Streptozotocin,NSC-85998,U 9889 DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th...
TWO2759 Thymine 5-methyluracil Others , Endogenous Metabolite
One of the pyrimidine bases of living matter. Derivation: Hydrolysis of deoxyribonucleic acid, from methylcyanoacetylurea by catalytic reduction. Use: Biochemical research. Thymine (5-methyluracil) is a pyrimidine nucleo...
T4877 L-Homocystine Endogenous Metabolite
Homocystine is the double-bonded form of homocysteine, but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Increasing evidence supports a role for an ele...
T8274 3-Methyl-L-histidine Endogenous Metabolite
3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t...
T9456 4-Methoxy 17β-Estradiol Others
4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
T13749 L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid Others
L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Ad...
T9455 4-hydroxyestrone-4-methyl ether 4-Methoxy Estrone Estrogen Receptor/ERR , Endogenous Metabolite
4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) is the methylation of 4-OHE1, which is catalyzed by COMT.
T10194 7-Methylguanine Others
7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method.

Natural Products

5-Azacytidine
T1339
Synonym: Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-AzaC
Target: Nucleoside Antimetabolite/Analog, DNA Methyltransferase, Antibacterial, Antibiotic, Autophagy
5-Methylcytosine
T5270
Synonym:
Target: Others, DNA/RNA Synthesis, Endogenous Metabolite
Vaccarin
T3881
Synonym:
Target: Integrin, Akt, PERK, AMPK
N-Methylnicotinamide
T5233
Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide
Target: Others, Endogenous Metabolite
Uracil
T0069
Synonym:
Target: Others, Endogenous Metabolite
Streptozocin
T1507
Synonym: STZ,Streptozotocin,NSC-85998,U 9889
Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy
Thymine
TWO2759
Synonym: 5-methyluracil
Target: Others, Endogenous Metabolite
L-Homocystine
T4877
Synonym:
Target: Endogenous Metabolite
3-Methyl-L-histidine
T8274
Synonym:
Target: Endogenous Metabolite
4-Methoxy 17β-Estradiol
T9456
Synonym:
Target: Others
L-2-Hydroxyglutaric acid
T13749
Synonym: (S)-2-Hydroxyglutaric acid
Target: Others
4-hydroxyestrone-4-methyl ether
T9455
Synonym: 4-Methoxy Estrone
Target: Estrogen Receptor/ERR, Endogenous Metabolite
7-Methylguanine
T10194
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (46)
Mouse (3)
Cynomolgus (2)
Rat (2)
ZEBOV (2)
Canine (1)
E. coli (1)
MARV (1)
Rabbit (1)
SARS-CoV-2 (1)
Expression System：
E. coli (40)
HEK293 (13)
Baculovirus-Insect Cells (7)
Tag：
His (10)
Tag Free (8)
GST (7)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (7)
N-terminal 6xHis-SUMO-tagged (7)
His,GST (4)
N-terminal 6xHis-tagged (4)
C-His (3)
C-hFc (3)
hFc (2)
Cat No. Product Name Species Expression System
TMPY-04722 DcR1/TRAILR3 Protein, Human, Recombinant (His) Human HEK293
TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most ...
TMPY-01285 METTL11A Protein, Human, Recombinant Human E. coli
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPY-01284 METTL11A Protein, Human, Recombinant (GST) Human E. coli
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPH-02246 TGS1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and...
TMPH-01681 METTL4 Protein, Human, Recombinant (His & Myc) Human E. coli
N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U...
TMPK-00678 CALCA/CGRP Protein, Mouse, Recombinant (hFc) Mouse HEK293
Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 a...
TMPK-01142 SFRP2 Protein, Human, Recombinant (His) Human HEK293
As biomarkers, DNA methylation is used to detect colorectal cancer (CRC) and make assessment of CRC prognosis. The published findings showed the association between the methylation of SFRP1, SFRP2, and WIF1, located in t...
TMPH-02311 WDR5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histon...
TMPY-05168 Syndecan-2 Protein, Mouse, Recombinant (His) Mouse HEK293
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC).
TMPY-04249 Syndecan-2 Protein, Human, Recombinant (His) Human HEK293
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC).
TMPH-01698 MORC4 Protein, Human, Recombinant (His & Myc) Human E. coli
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2...
TMPK-00669 SFRP2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
As biomarkers, DNA methylation is used to detect colorectal cancer (CRC) and make assessment of CRC prognosis. The published findings showed the association between the methylation of SFRP1, SFRP2, and WIF1, located in t...
TMPY-02957 DYDC2 Protein, Human, Recombinant (GST) Human E. coli
DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays...
TMPH-01734 METTL3 Protein, Human, Recombinant (His) Human E. coli
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of emb...
TMPY-04424 MST3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis pla...
TMPK-01308 TAG-72 Protein, Canine, Recombinant (His) Canine E. coli
The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA...
TMPH-01712 TRMT112 Protein, Human, Recombinant (His & SUMO) Human E. coli
Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylat...
TMPY-02420 HEMK2 Protein, Human, Recombinant (His) Human E. coli
N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to t...
TMPY-02340 HNMT Protein, Human, Recombinant (GST) Human E. coli
HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabol...
TMPK-00723 RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) Mouse HEK293
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPY-03046 APCDD1 Protein, Human, Recombinant (hFc) Human HEK293
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, res...
TMPH-01529 INMT Protein, Human, Recombinant (His & SUMO) Human E. coli
Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, ...
TMPY-02378 14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST) Human E. coli
The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclamp...
TMPK-00351 RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) Human HEK293
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPH-00886 ATF7IP2 Protein, Human, Recombinant (His) Human E. coli
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the conte...
TMPY-01708 DOT1L Protein, Human, Recombinant Human E. coli
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil...
TMPY-04417 DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) Human Baculovirus-Insect Cells
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK...
TMPH-01526 KMT2E Protein, Human, Recombinant (His & Myc) Human E. coli
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4'...
TMPY-00624 PEAR1 Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
Platelet endothelial aggregation receptor-1 (PEAR1), an epidermal growth factor repeat-containing transmembrane receptor, is known to participate in platelet contact-induced activation. Platelet endothelial aggregation r...
TMPY-01584 PR-Set7 Protein, Human, Recombinant Human E. coli
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of...
TMPH-01679 WDR77 Protein, Human, Recombinant (His & SUMO) Human E. coli
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets ...
TMPH-01697 MORC3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in ...
TMPJ-01118 GNMT Protein, Human, Recombinant (His) Human E. coli
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation b...
TMPH-03735 Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc) ZEBOV E. coli
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras...
TMPH-03734 Zaire ebolavirus (strain Mayinga-76) L Protein (His) ZEBOV E. coli
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras...
TMPH-02384 Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc) MARV E. coli
RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymeras...
TMPH-02105 ASH2L Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 ...
TMPY-02573 IL-17RC Protein, Human, Recombinant (aa 1-454, His) Human Baculovirus-Insect Cells
IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). IL17RC is widely expressed in the pr...
TMPY-03508 XTP3TPA Protein, Human, Recombinant (His) Human E. coli
DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-d...
TMPY-02691 IL-17RC Protein, Human, Recombinant(aa 1-454, hFc) Human HEK293
IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). IL17RC is widely expressed in the pr...
TMPY-02379 EED Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. EED depletion significantly impeded erythroid maturation. EED depletion imp...
TMPY-04770 RIOK1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
RIOK1, also known as RIO kinase 1, is a member of the RIO family of atypical serine protein kinases first characterized in yeast. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. RIOK1 functions ...
TMPH-01631 DCP2 Protein, Human, Recombinant (His) Human E. coli
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the ...
TMPY-05693 SARS-CoV-2 Methyltransferase/ME Protein (His) SARS-CoV-2 E. coli
Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate...
TMPH-03209 CLNS1A Protein, Rabbit, Recombinant (His & Myc) Rabbit E. coli
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blo...
TMPY-04403 NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho...
TMPY-02513 Pepsinogen C/PGC Protein, Rat, Recombinant (His) Rat HEK293
Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a pro...
TMPY-01731 Pepsinogen C/PGC Protein, Human, Recombinant (His) Human HEK293
Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a pro...
TMPH-02286 USP7 Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M...
TMPY-01383 PRMT6 Protein, Human, Recombinant (His & Flag) Human HEK293
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex...
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DcR1/TRAILR3 Protein, Human, Recombinant (His)
TMPY-04722
Species: Human
Expression System: HEK293
METTL11A Protein, Human, Recombinant
TMPY-01285
Species: Human
Expression System: E. coli
METTL11A Protein, Human, Recombinant (GST)
TMPY-01284
Species: Human
Expression System: E. coli
TGS1 Protein, Human, Recombinant (His & SUMO)
TMPH-02246
Species: Human
Expression System: E. coli
METTL4 Protein, Human, Recombinant (His & Myc)
TMPH-01681
Species: Human
Expression System: E. coli
CALCA/CGRP Protein, Mouse, Recombinant (hFc)
TMPK-00678
Species: Mouse
Expression System: HEK293
SFRP2 Protein, Human, Recombinant (His)
TMPK-01142
Species: Human
Expression System: HEK293
WDR5 Protein, Human, Recombinant (His & SUMO)
TMPH-02311
Species: Human
Expression System: E. coli
Syndecan-2 Protein, Mouse, Recombinant (His)
TMPY-05168
Species: Mouse
Expression System: HEK293
Syndecan-2 Protein, Human, Recombinant (His)
TMPY-04249
Species: Human
Expression System: HEK293
MORC4 Protein, Human, Recombinant (His & Myc)
TMPH-01698
Species: Human
Expression System: E. coli
SFRP2 Protein, Cynomolgus, Recombinant (His)
TMPK-00669
Species: Cynomolgus
Expression System: HEK293
DYDC2 Protein, Human, Recombinant (GST)
TMPY-02957
Species: Human
Expression System: E. coli
METTL3 Protein, Human, Recombinant (His)
TMPH-01734
Species: Human
Expression System: E. coli
MST3 Protein, Human, Recombinant (His)
TMPY-04424
Species: Human
Expression System: Baculovirus-Insect Cells
TAG-72 Protein, Canine, Recombinant (His)
TMPK-01308
Species: Canine
Expression System: E. coli
TRMT112 Protein, Human, Recombinant (His & SUMO)
TMPH-01712
Species: Human
Expression System: E. coli
HEMK2 Protein, Human, Recombinant (His)
TMPY-02420
Species: Human
Expression System: E. coli
HNMT Protein, Human, Recombinant (GST)
TMPY-02340
Species: Human
Expression System: E. coli
RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)
TMPK-00723
Species: Mouse
Expression System: HEK293
APCDD1 Protein, Human, Recombinant (hFc)
TMPY-03046
Species: Human
Expression System: HEK293
INMT Protein, Human, Recombinant (His & SUMO)
TMPH-01529
Species: Human
Expression System: E. coli
14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST)
TMPY-02378
Species: Human
Expression System: E. coli
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)
TMPK-00351
Species: Human
Expression System: HEK293
ATF7IP2 Protein, Human, Recombinant (His)
TMPH-00886
Species: Human
Expression System: E. coli
DOT1L Protein, Human, Recombinant
TMPY-01708
Species: Human
Expression System: E. coli
DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)
TMPY-04417
Species: Human
Expression System: Baculovirus-Insect Cells
KMT2E Protein, Human, Recombinant (His & Myc)
TMPH-01526
Species: Human
Expression System: E. coli
PEAR1 Protein, Rat, Recombinant (His)
TMPY-00624
Species: Rat
Expression System: Baculovirus-Insect Cells
PR-Set7 Protein, Human, Recombinant
TMPY-01584
Species: Human
Expression System: E. coli
WDR77 Protein, Human, Recombinant (His & SUMO)
TMPH-01679
Species: Human
Expression System: E. coli
MORC3 Protein, Human, Recombinant (His & SUMO)
TMPH-01697
Species: Human
Expression System: E. coli
GNMT Protein, Human, Recombinant (His)
TMPJ-01118
Species: Human
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc)
TMPH-03735
Species: ZEBOV
Expression System: E. coli
Zaire ebolavirus (strain Mayinga-76) L Protein (His)
TMPH-03734
Species: ZEBOV
Expression System: E. coli
Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc)
TMPH-02384
Species: MARV
Expression System: E. coli
ASH2L Protein, Human, Recombinant (His & SUMO)
TMPH-02105
Species: Human
Expression System: E. coli
IL-17RC Protein, Human, Recombinant (aa 1-454, His)
TMPY-02573
Species: Human
Expression System: Baculovirus-Insect Cells
XTP3TPA Protein, Human, Recombinant (His)
TMPY-03508
Species: Human
Expression System: E. coli
IL-17RC Protein, Human, Recombinant(aa 1-454, hFc)
TMPY-02691
Species: Human
Expression System: HEK293
EED Protein, Human, Recombinant (His & GST)
TMPY-02379
Species: Human
Expression System: Baculovirus-Insect Cells
RIOK1 Protein, Human, Recombinant (His & GST)
TMPY-04770
Species: Human
Expression System: Baculovirus-Insect Cells
DCP2 Protein, Human, Recombinant (His)
TMPH-01631
Species: Human
Expression System: E. coli
SARS-CoV-2 Methyltransferase/ME Protein (His)
TMPY-05693
Species: SARS-CoV-2
Expression System: E. coli
CLNS1A Protein, Rabbit, Recombinant (His & Myc)
TMPH-03209
Species: Rabbit
Expression System: E. coli
NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)
TMPY-04403
Species: Human
Expression System: Baculovirus-Insect Cells
Pepsinogen C/PGC Protein, Rat, Recombinant (His)
TMPY-02513
Species: Rat
Expression System: HEK293
Pepsinogen C/PGC Protein, Human, Recombinant (His)
TMPY-01731
Species: Human
Expression System: HEK293
USP7 Protein, Human, Recombinant (His & Myc & SUMO)
TMPH-02286
Species: Human
Expression System: E. coli
PRMT6 Protein, Human, Recombinant (His & Flag)
TMPY-01383
Species: Human
Expression System: HEK293
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Cat No. Product Name
L3510 Methylation Compound Library

131 compounds
131 methylation-related compounds that can be used for high-throughput and high-content screening.
L3500 Histone Modification Compound Library

480 compounds
A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L1200 Epigenetics Compound Library

960 compounds
Well-chosen 960 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L8300 Chromatin Modification Compound Library

256 compounds
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);

Libraries

Methylation Compound Library
L3510
Compounds: 131
Histone Modification Compound Library
L3500
Compounds: 480
Epigenetics Compound Library
L1200
Compounds: 960
Chromatin Modification Compound Library
L8300
Compounds: 256
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