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Cat No. | Product Name | Synonyms | Targets |
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T10016 | Hydrocarbon chain derivative 1 | 6,6'-Oxybis[2,2-dimethyl-1-hexanol] | Others |
Hydrocarbon chain derivative 1 has inhibitory activities against lipid synthesis. | |||
T7202 | ITE | AhR , Aryl Hydrocarbon Receptor | |
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity. | |||
T1960 | YL-109 | AhR , Aryl Hydrocarbon Receptor | |
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo. | |||
T21966 | MeBIO | GSK-3 , Aryl Hydrocarbon Receptor , CDK | |
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β. | |||
T4608 | PDM2 | AhR , Aryl Hydrocarbon Receptor | |
PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. | |||
T15410 | GNF351 | Aryl Hydrocarbon Receptor | |
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes wit... | |||
T2448 | CH-223191 | CH 223191 | AhR , Aryl Hydrocarbon Receptor |
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR). | |||
T5622 | BAY-218 | AHR antagonist 1 | AhR , Aryl Hydrocarbon Receptor |
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line. | |||
T20625 | Prochloraz | Sporgon,Prelude | Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal |
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... | |||
T4607 | CAY 10465 | CAY10465,CAY10465 Exclusive | AhR , Aryl Hydrocarbon Receptor |
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM). | |||
T10270 | BAY 2416964 | Aryl Hydrocarbon Receptor | |
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 192, IC50: 341 nM). It has the potential for cancer treatment. | |||
T10007 | 1,4-Chrysenequinone | Chrysene-1,4-dione | AhR |
1,4-Chrysenequinone (Chrysene-1,4-dione) is an activator of aryl hydrocarbon receptor (AhR). | |||
TQ0257 | FICZ | 6-Formylindolo[3,2-b]carbazole | Aryl Hydrocarbon Receptor |
FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM). | |||
T1831 | StemRegenin 1 | SR1 | AhR , Aryl Hydrocarbon Receptor |
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor. | |||
T21704 | 5-fluoro 203 | 5F-203,NSC-703786 | Others |
5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells... | |||
T13276 | VAF347 | Aryl Hydrocarbon Receptor | |
VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects. | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. | |||
T2148 | Carbidopa monohydrate | Carbidopa Hydrate,S(-)-Carbidopa | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine. | |||
T4644 | Tapinarof | GSK2894512,Benvitimod,WBI 1001 | AhR , Aryl Hydrocarbon Receptor |
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease. | |||
T0640 | Benzyl butyl phthalate | BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate | Others , Aryl Hydrocarbon Receptor |
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC. | |||
T2707 | Pifithrin-α hydrobromide | Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide | Ferroptosis , Aryl Hydrocarbon Receptor , p53 |
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes. | |||
T8980 | SGA360 | Aryl Hydrocarbon Receptor | |
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties. | |||
T0352 | Dibenzothiophene | Imino semicarbazide,Diphenylene sulfide | Others |
Dibenzothiophene (Imino semicarbazide), a component of petroleum oils, is a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratolytic activity. | |||
T10269 | AHR antagonist 2 | Aryl Hydrocarbon Receptor | |
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively. | |||
T5541 | PDM11 | 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11 | AhR |
PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR) | |||
T19057 | Solvent Blue 35 | Sudan Blue II,Oil Blue 35 | Others |
Solvent Blue 35 (Sudan Blue II) (Sudan Blue II) is a dye used for coloring hydrocarbon-based and alcoholic solvents. It is used for staining triglycerides in animal tissues. | |||
T10325 | ANI-7 | Chk | |
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breast cancer cells (GI50: 0.56 μM). | |||
T34298 | Retene | NSC 26317,NSC-26317,NSC26317 | |
Retene (NSC-26317) is widely present in recent and ancient sediments, and compounds can be extracted from fir forest soils, humic coals, terrestrial petroleum hydrocarbon source rocks, and deep-sea sediments.Retene is pr... | |||
T10526 | β-NF-JQ1 | Others | |
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein inter... | |||
T3637 | Pifithrin-β hydrobromide | Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) | Ferroptosis , p53 |
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder... | |||
T36696 | DMBA | ||
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... | |||
T24960 | 10-Cl-BBQ | 10ClBBQ | |
10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR). | |||
T25235 | CHD-5 | CHD5 | |
CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR). | |||
T23994 | Dibenzo(a,i)pyrene | DB(a,i)p,Benzo(rst)pentaphene | |
Dibenzo(a, i)pyrene is a polycyclic aromatic hydrocarbon with potent carcinogenic activity. | |||
T16082 | Mivotilate | YH439 | Others |
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. | |||
T23686 | AHR-activator-1023 | Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023 | |
AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator. | |||
T20307 | Benzyl 2-naphthyl ether | AI3 00945,AI300945,AI3-00945 | |
Benzyl 2-naphthyl ether causes the activation of the aryl hydrocarbon receptor. | |||
T10271 | AHR antagonist 4 | Others | |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T19927 | Asphalt | Bitumen,Asphalt fumes,Dacholeum | |
Asphalt is a dark liquid. It is also a mixture of heavy hydrocarbon residues including saturated and unsaturated hydrocarbons and aromatic hydrocarbons. | |||
T70240 | Caparratriene | ||
Caparratriene is a new sesquiterpene hydrocarbon isolated from Ocotea caparrapi with potential for significant growth inhibitory activityagainst CEM leukemia cells | |||
T22528 | 6,2',4'-Trimethoxyflavone | Others | |
The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence. | |||
T20161 | Lauroyl alanine | Lauroylalanine,N-Lauroyl-L-alanine,Aminiosurfact LA | |
Lauroyl alanine is a fatty acid amide. It may be used to support the physical gelation of binary mixtures of aliphatic and aromatic hydrocarbon solvents. | |||
T23400 | StemRegenin 1 (hydrochloride) | StemRegenin 1 (hydrochloride) (1227633-49-9 free base) | Others |
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells). | |||
T22725 | DiMNF | Others | |
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment. | |||
T32115 | Hydrogenated didecene | 1-Decene,dimers,Dec-1-ene,hydrogenated,dimer | |
Hydrogenated didecene as skin-softening agent derived from didecene, which is a hydrocarbon. Hydrocarbons are organic compounds that contain only carbon and hydrogen. Examples of common hydrocarbons include mineral oil, ... | |||
T10258 | AFP464 free base | NSC710464 free base | HIF |
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator. | |||
T14059 | 6-Maleimidocaproic acid-PFP ester | Others | |
6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker, suitable for the synthesis of PROTACs[1]. | |||
T10272 | AHR antagonist 5 | Others | |
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. | |||
T71938 | MNF | ||
MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS). | |||
T38393 | Ipatasertib-NH2 dihydrochloride | RG7440-NH2 dihydrochloride,Ipatasertib-NH2 dihydrochloride,GDC-0068-NH2 dihydrochloride | |
Ipatasertib-NH2 dihydrochloride is a ligand for the target protein AKT in PROTAC INY-03-041. INY-03-041 consists of Ipatasertib-NH2, a ten-hydrocarbon linker, and the CRBN ligand Lenalidomide, which acts as an E3 ubiquit... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7914 | Acenaphthylene | Others | |
Acenaphthylene is environmental polycyclic aromatic hydrocarbon (PAH)pollutants | |||
TN1451 | Brevifolincarboxylic acid | AhR , Aryl Hydrocarbon Receptor , Glucosidase | |
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 3... | |||
T6795 | Carbidopa | (S)-(-)-Carbidopa,Lodosyn | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. | |||
TN6925 | Pristane | 2,6,10,14-tetramethylpentadecane | Others |
Pristane (2,6,10,14-tetramethylpentadecane) is a natural product from shark liver oil and a non-antigenic adjuvant. | |||
T4928 | L-Kynurenine | (S)-Kynurenine | AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite |
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ... | |||
T0878 | Diosmin | Venosmine,Diosmil,Barosmin | Aryl Hydrocarbon Receptor , Norepinephrine |
Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls. | |||
TN2883 | 3',4'-Dimethoxyflavone | Others , PARP | |
3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities. | |||
T4939 | Indole-3-pyruvic acid | 3-(3-Indolyl)-2-oxopropanoic acid | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta... | |||
T5281 | Skatole | Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole | AhR , p38 MAPK , Aryl Hydrocarbon Receptor , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal |
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. | |||
T2947 | Indole-3-carbinol | I3C,3-Indolemethanol,Indole-3-Methanol | E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53 |
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation. | |||
T14961 | Chrysene | 䓛 | Others |
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH). | |||
T5226 | 2-(2-Methylbenzamido)acetic acid | 2-Methylhippuric acid,O-Toluric acid,N-(O-Toluoyl)glycine | Others , Endogenous Metabolite |
2-(2-Methylbenzamido)acetic acid (O-Toluric acid) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. In certain cases, the measurement of these metabolites in body fluids can be used to diag... | |||
TN6835 | (E)-β-Farnesene | (6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene | Antifungal |
(E)-β-Farnesene (trans-β-Farnesene) is a sesquiterpene hydrocarbon present in Phlomis aurea Decne and is the main component of many aphid alarm pheromones that interrupt aphid feeding. (E)-β-Farnesene impairs development... | |||
T3776 | Rhapontigenin | Protigenin | P450 , Antibacterial , Antifungal |
Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R... | |||
TN6694 | 5,6-Benzoflavone | β-Naphthoflavone,beta-NF | Antioxidant |
5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a... | |||
T2864 | Lycopene | ψ,ψ-Carotene | Reactive Oxygen Species , ROS |
Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. As a class, carotenoids ... | |||
T4938 | Potassium 1H-indol-3-yl sulfate | Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate | AhR , Endogenous Metabolite |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm... | |||
TN6366 | Lupinalbin A | ||
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine... | |||
T82897 | Benzo[e]pyrene | ||
Benzo[e]pyrene, a highly toxic polyaromatic hydrocarbon (PAH), is found in fossil fuels [1]. | |||
T78469 | α-Copaene | ||
Alpha-Copaene (α-Copaene), a sesquiterpene hydrocarbon and volatile compound found in fruit, acts as an oviposition promoter for Bactrocera oleae [1]. | |||
T75433 | Norisoboldine hydrochloride | ||
Norisoboldine hydrochloride, an orally active aryl hydrocarbon receptor (AhR) agonist and a prominent isoquinoline alkaloid found in Radix Linderae, is utilized for research purposes in the study of Rheumatoid Arthritis ... | |||
T73402 | Flavipin | ||
Flavipin, an aryl hydrocarbon receptor (Ahr) agonist, activates Ahr downstream gene expression in mouse CD4+ T cells and CD11b+ macrophages. This compound disrupts the stabilizing effect of Arid5a on the newly identified... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00958 | AHR Protein, Human, Recombinant (His) | Human | E. coli |
AHR Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-00957 | ARNT Protein, Human, Recombinant (His) | Human | Yeast |
ARNT Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPY-01709 | HIF-1 alpha Protein, Human, Recombinant (His) | Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (... |