ecm

Pyrintegrin, a β1-integrin agonist, promotes the survival of embryonic stem cells, can be used as a podocyte-protective agent, and enhances cell-extracellular matrix adhesion-mediated integrin signaling.

Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX-2, and PPAR-γ. In LPS-stimulated RAW 264.7 macrophages, it exerts anti-inflammatory activity by inhibiting the ERK signaling pathway.

Flunisolide (Rhinalar) is a synthetic corticosteroid with anti-inflammatory and antiallergic properties.

ecMetAP-IN-1 can be used as a QSAR model to study methionine aminopeptidase inhibitor as an anticancer agent using multiple linear regression.

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) is an IgG1, κ inhibitor antibody derived from rats, targeting mouse E-Cadherin/CD324.

Enalapril Maleate (MK-421 Maleate), an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy.

Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM), thereby dose-dependently inhibiting the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

Gynostemma Extract (Gypenoside IX) is a saponins extract derived from the Gynostemma pentaphyllum.

CM Cellulose CM-32 is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.

BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxide dismutase 3 (SOD3) and regulating chondrogenesis through superoxide anion elimination.

ATN-161 acetate, a pentapeptide compound derived from the synergistic region of fibronectin, is a non-competitive integrin-alpha5 antagonist with antitumor activity that attenuates the pathology of caerulein-induced acute pancreatitis.

Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an analogue of AMR69. Which displays equivalent lower toxicity, antifibrotic activity, and longer half-life.

Collagenase Type VIII hydrolyses Type VIII collagen and can be used to study collagen metabolism processes in the pathophysiology of atherosclerosis. Collagenase Type VIII can also hydrolyse other protein components in the extracellular matrix (ECM), making it useful for tissue dissociation and cell separation.

Autotaxin-IN-7 (45) is a pyridine-2-carboxylic acid derivative exhibiting sub-nanomolar inhibition of ATX (IC50 = 0.086 nM) and features excellent cardiac safety (hERG > 30 μM) with minimal toxicity to fibroblasts. It inhibits the TGF-β/Smad signaling pathway, reducing α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) can be used in pulmonary fibrosis research.

CYD0682 is an analog of Oridonin. It reduces the activation of STAT3 and the production of ECM in hepatic stellate cells via the HSP90 pathway.

2ccPA is a derivative of cyclic phosphatidic acid. It reduces the expression of extracellular matrix (ECM) and increases intracellular cAMP levels. 2ccPA decreases the protein expression levels of type I collagen, CCN2, and αSMA. By inhibiting the production of ECM by activated dermal fibroblasts, 2ccPA hinders the progression of skin fibrosis.

Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that establishes cross-links between extracellular matrix (ECM) components through the catalytic activity of the enzyme tissue transglutaminase (tTg), and Epsilon-(gamma-glutamyl)-lysine has been implicated in the pathological remodeling of tissues in diseases such as non-diabetic kidney disease and in the progression of glaucoma filtration, rendering it a critical biomarker and mechanistic factor in extracellular matrix biology.

Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis and inhibit the growth of lung cancer cells in anchorage-independent condition. Chrysotobibenzyl is therefore used in cancer metastasis research models to investigate anoikis-associated cell death mechanisms and anchorage-independent growth regulation in lung cancer cell systems. Chrysotobibenzyl is also applied in extracellular matrix detachment studies to evaluate survival signaling changes under non-adherent cellular conditions.

Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA, an N(6)-acyl-L-lysine derivative, is crucial in forming epsilon-(gamma-glutamyl)lysine crosslinks within extracellular matrix (ECM) components, facilitated by tissue transglutaminase (tTg), and is significant in diseases like non-diabetic kidney disease and glaucoma filtration [1].

RGD peptide (GRGDNP) TFA functions as an inhibitor of integrin-ligand interactions, competitively blocking α5β1's interaction with the extracellular matrix (ECM). It induces apoptosis by triggering conformational changes that facilitate pro-caspase-3 activation and autoprocessing. Furthermore, RGD peptide (GRGDNP) TFA is critical in regulating cell adhesion, migration, growth, and differentiation [1] [2] [3].

H-Ile-Lys-Val-Ala-Val-OH (IKVAV) is a short peptide with a sequence length of 5, present in the extracellular matrix (ECM), on the α-laminin chain. H-Ile-Lys-Val-Ala-Val-OH participates in a variety of life activities, such as promoting cell adhesion, neurite outgrowth, angiogenesis, collagenase IV production and tumor growth. H-Ile-Lys-Val-Ala-Val-OH can induce rapid differentiation of neural progenitor cells into neurons and neurite outgrowth.

Plasminogen is a zymogen secreted as a precursor protein that, when cleaved by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA), is converted into plasmin. Plasmin is a protease with broad specificity, capable of degrading fibrin and various extracellular matrix (ECM) components. Additionally, plasminogen functions as a proinflammatory regulator, promoting the healing of both acute and diabetic wounds. It is utilized in research related to wound healing, inflammation, and hypoplasminogenemia [1] [2].

Tetrapeptide-21 (GEKG peptide) is a bioactive peptide composed of four amino acids that effectively enhances the activity of human dermal fibroblasts. It upregulates the expression of key extracellular matrix (ECM)-related genes and promotes the synthesis of ECM proteins, including type I collagen, hyaluronan synthase 1, and fibronectin. Due to its anti-wrinkle and skin elasticity-improving effects, Tetrapeptide-21 has been reported as an ingredient in cosmetic products.