alcohol

Linoleyl alcohol (CIS,CIS-9,12-OCTADECADIENOL), fatty alcohol, is a structural analog of Linoleic acid with no a-carboxyl group[1].

D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose, occurring naturally and also produced synthetically from glucose. Formerly used as a diuretic, it may still be used as a laxative and in irrigating solutions for certain surgical procedures. It is also utilized in various manufacturing processes, as a pharmaceutical aid, and in several research applications.

Fomepizole (4-Methylpyrazole) is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole(4-Methylpyrazole) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized for its potential as a biofuel, possessing diesel-like properties[2].

Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic piperazine derivative with hypotensive antiadrenergic properties, It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor[3]. COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1].COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. [1]. Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. [2]. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci. 2020 Dec 1;155:105544. [3]. Paola Maccioni, et al. Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues. Alcohol. 2019 Mar;75:55-66.

Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration with the concentration dependent manner.

2,4-Dichlorobenzyl alcohol ,with CAS No. 1777-82-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,4-Dichlorobenzyl alcohol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Nitrobenzyl alcohol ,with CAS No. 612-25-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Nitrobenzyl alcohol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Nitrobenzyl alcohol (4-Nitrobenzenemathanol) ,with CAS No. 619-73-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Nitrobenzyl alcohol (4-Nitrobenzenemathanol) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Aminobenzyl alcohol ,with CAS No. 623-04-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Aminobenzyl alcohol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-[1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzyl alcohol ,with CAS No. 892502-29-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-[1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzyl alcohol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.

Azide-PEG12-alcohol, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

4-(Trifluoromethoxy)benzyl alcohol, with CAS No. 1736-74-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(Trifluoromethoxy)benzyl alcohol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Mebeverine alcohol [Mebeverine metabolite]: Mebeverine alcohol is a primary metabolite of the antispasmodic agent Mebeverine.

Mebeverine metabolite O-desmethyl Mebeverine alcohol is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract. Mebeverine metabolite O-desmethyl Mebeverine alcohol is a metabolite of Mebeverine.

Caffeoyl alcohol is a useful organic compound for research related to life sciences and the catalog number is T124955.

Abscisic alcohol is a useful organic compound for research related to life sciences. The catalog number is T126360 and the CAS number is 113472-20-1.

1,1,1-Trifluoroethyl-PEG4-alcohol is a polyethylene glycol (PEG) derivative typically used as a linker in the synthesis of protein degrader molecules, known as PROTACs [1].

1-Isothiocyanato-PEG4-alcohol, a polyethylene glycol (PEG)-derived linker compound, is suitable for incorporation into Proteolysis Targeting Chimeras (PROTACs).

(2-Pyridyldithio)-PEG4-alcohol, a PEG-based PROTAC linker, is used for the synthesis of PROTACs[1].

Amino-PEG4-alcohol is a PEG-based PROTAC linker used for synthesizing PROTACs[1] and a non-cleavable 4-unit PEG ADC linker for synthesizing antibody-drug conjugates (ADCs)[2].

Amino-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].