mdr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0026	MDR-1339	DWK-1339	Beta Amyloid , Gamma-secretase
	MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.		Beta Amyloid , Gamma-secretase
T22360	MDR-652		TRP/TRPV Channel
	MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ...		TRP/TRPV Channel
T41248	Thiocolchicine		Microtubule Associated
	Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.		Microtubule Associated
T11888	LtaS-IN-1		Others , Antibacterial
	LtaS-IN-1 is an effective inhibitor of Lipoteichoic acid synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC value...		Others , Antibacterial
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate		Antibacterial
	Benzyldodecyldimethylammonium chloride dihydrate can be used as an insecticide reagent. It can target drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aerugino...		Antibacterial
T6685	Sulbactam sodium	CP-45899-2	Antibacterial , Antibiotic
	Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor.		Antibacterial , Antibiotic
T4989	Fosfomycin Tromethamine		Antibacterial , Antibiotic
	An antibiotic produced by Streptomyces fradiae.		Antibacterial , Antibiotic
T1631	Sulbactam	CP45899	Antibacterial , Antibiotic
	Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol...		Antibacterial , Antibiotic
T3131	Fosfomycin calcium	Phosphomycin calcium salt,Fosmicin	Antibacterial , Antibiotic
	Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis.		Antibacterial , Antibiotic
T8262	Fosfomycin sodium	Fosfomycin Disodium	Antibacterial , Antibiotic
	Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e...		Antibacterial , Antibiotic
T19768	γ-Tocotrienol	gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol	Others
	γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.		Others
T11983	MDRTB-IN-1		Others
	MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv(MIC90 :10.5 μM).		Others
T17216	Valspodar	PSC 833	P-gp
	Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.		P-gp
T16098	Islatravir	MK-8591	HIV Protease , Reverse Transcriptase
	Islatravir (MK-8591) is an effective anti-HIV-1 agent. It acts as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively).		HIV Protease , Reverse Transcriptase
T11071	Dofequidar fumarate	MS-209	P-gp
	Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass...		P-gp
TN1731	Hernandezine		TNF , ROS , P-gp , AMPK
	Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.		TNF , ROS , P-gp , AMPK
T9587	CCTA-1523		Others , ABC
	CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.		Others , ABC
T67790	Biricodar dicitrate	VX 710,VX 710-3	NF-κB , AChR
	Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.		NF-κB , AChR
T67912	PA3552-IN-1
	PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B.
T15168	DRF-1042		Others
	DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.		Others