α-cp2

p27 Analogue CP2 is a macrocyclic peptide inhibitor that targets the SCFSkp2/Cks1 E3 ubiquitin ligase complex (Kd=32 nM). By preventing the ubiquitination and subsequent degradation of the p27 protein mediated by SCFSkp2/Cks1, it helps restore p27 levels and inhibits cell proliferation. This compound shows potential for research on cancers that rely on Skp2 overexpression, such as breast cancer.

CP2 is a useful organic compound for research related to life sciences and the catalog number is T35338.

CP-28888 (CP 28888-27) is an interferon inducer, a lipoamine with antitumor activity.

OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.

Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.

BrBzGCp2 (p BrBzGSH(Cp)2) is an inhibitor of glyoxalase 1 (GLO1) with antitumor and neuroprotective activity. It can alleviate anxiety and be used in neurodegenerative disease research.

Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.

Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.

Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.

CP-226269 is a potent dopamine D4 receptor agonist that regulates calcium flux and has an EC50 value of 32.0 nM. CP 226269 can be used to study neurological disorders such as schizophrenia.

CP-20961 is an effective synthetic non-immunogenic adjuvant that can be used to induce acute and chronic arthritis models.

TFCP2L1-IN-1 is a TFCP2L1 transcription factor inhibitor that regulates cell proliferation and pluripotency.TFCP2L1 (transcription factor CP2-like 1) plays a key role in maintaining pluripotency in mouse and human embryonic stem cells (ESCs). TFCP2L1-IN-1 is capable of promoting the anti-tumor effects of Sorafenib by inhibiting the STAT3/NANOG pathway.

Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.

Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM). It inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and can be utilized in cancer research.

P2X3 and P2X2/3 receptor antagonist

CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.

CP-281384 is a potent, p38alpha-selective inhibitor.

CP-293019 is a potent, selective antagonist of dopamine D4 receptor.

JCP-265 is an ABHD6 inhibitor.

CP 220629 is a potent inhibitor of phosphodiesterase IV (PDE4).

CP-22185 is a bio-active chemical.

CP-283097 is an N-methyl-D-aspartic acid (NMDA) receptor antagonist with NR2B subunit.

CP-294838 is a bioactive chemical.