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(1052)
Sort by SourceMarine Natural Product
The ocean is a complex system spanning vast temporal and spatial scales, formed by the highly coupled physical, chemical, biological, and geological processes. Under the long-term evolutionary pressures of extreme environments—including high salinity, low temperatures, low light levels, and high pressure—marine organisms have developed genomic structures and metabolic regulatory mechanisms distinct from terrestrial life. This unique ecological adaptation has driven marine organisms to produce a vast array of marine natural products characterized by novel structures, diverse types, and significant biological activity. These bioactive molecules demonstrate considerable potential in anti-tumor, anti-infective, anti-inflammatory, and immunomodulatory researches.
Staurosporine
Cited
CGP 41251, Antibiotic AM-2282, AM-2282
T668062996-74-1
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
- $56
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CitedDidemnin B
NSC-325319, NSC325319, NSC 325319, Didemnin-B
T2532777327-05-0
Didemnin B (Didemnin-B) is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum that has antiviral and antitumor activity.
- $239
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(3E)-4-(1H-indol-3-yl)but-3-en-2-one
4-(1H-indol-3-yl)but-3-en-2-one, (E)-4-(1H-indol-3-yl)but-3-en-2-one
TN713957598-80-8
(3E)-4-(1H-indol-3-yl)but-3-en-2-one ((E)-4-(1H-indol-3-yl)but-3-en-2-one) is a marine derived natural products found in Tedania (Tedania) ignis.
- $195
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Cytarabine Cited
Cytosine β-D-arabinofuranoside, Cytosine Arabinoside, Ara-C, Arabinocytidine
T1272147-94-4
Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
ApoptosisAutophagyDNA/RNA SynthesisEndogenous MetaboliteHSVNucleoside Antimetabolite/AnalogVirus Protease
- $30
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CitedHymenidin
T27564107019-95-4In house
Hymenidin, an alkaloid isolated from the Okinawan sponge Hymeniacidon sp. is a 5-hydroxytryptaminergic receptor antagonist and voltage-gated potassium channel inhibitor with potential antiprotozoal effects.It selectively binds to FOXO1 DNA and reduces depolarization-induced elevation of cellular calcium.
- $2,420
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Marizomib
Salinosporamide A, NPI-0052, ML858
T16012437742-34-2
Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM.[3]
- $123
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Pristane
2,6,10,14-tetramethylpentadecane
TN69251921-70-6
Pristane (2,6,10,14-tetramethylpentadecane) is a natural product from shark liver oil and a non-antigenic adjuvant.
- $40
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Saringosterol
T688646901-60-6
Saringosterol is an antimicrobial phytosterol with inhibitory activity against Mycobacterium tuberculosis.
- $293
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Adenosine Cited
D-Adenosine, Adenine riboside
T085358-61-7
Adenosine (D-Adenosine) is a natural product, a ribonucleoside consisting of adenine bound to ribose. Adenosine has vasodilatory, antiarrhythmic and analgesic effects.
- $37
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CitedArcyriaflavin A
T21858118458-54-1In house
Arcyriaflavin A is derived from Eudistoma sp. It inhibits D1-CDK4, B-CDK1 and CaMKII with IC50 values of 0.14μM, 1.13μM and 0.025μM, respectively. Arcyriaflavin A also inhibits HCT-116 and NCI-H460 cells with IC50 values of 0.85μM and 0.59μM, respectively.
- $48
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Laminaran
β-1,3-Glucan
T157059008-22-4
Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers.
- $30
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Cyanosafracin B
Cyanoquinonamine, CBR28-1
T2228696996-50-8
Cyanosafracin B is a starting material for the synthesis of Phthalascidin Pt-650 and Ecteinascidin ET-743.
- $37
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ochracin Cited
Ochracin, 8-hydroxy-3-methylisochroman-1-one, 8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one, 3,4-Dihydro-8-hydroxy-3-methylisocoumarin
TN71561200-93-7
(S)-(+)-ochracin (8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one) is a marine derived natural products found in Helicascus kanaloanus.
- $115
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CitedPhenazine-1-carboxylic acid
TN71052538-68-3
Phenazine-1-carboxylic acid shows strong antifungal activity against all phytopathogenic fungi, inhibiting the fungal growth by about 90-100%. Phenazine-1-carboxylic acid could be used to compete with other phytopathogenic fungi that attack grapevine
- $35
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Turbinaric acid
T1394656882-00-9
Turbinaric acid is a moderately cytotoxic squalene carboxylic acid isolated from brown algae (Turbinaria ornata).
- $71
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2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
Meridianin C
TN7180213473-00-8
2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- (Meridianin C) is a marine derived natural products found in Aplidium meridianum.
- $36
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Dolastatin 10
NSC 376128, DLS 10
TP1180110417-88-4
Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
- $68
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Radicicol
Monorden
T1671912772-57-5
Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
- $139
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3,3'-Bi[1H-indole]
3,3'-Biindole, 3-(1H-indol-3-yl)-1H-indole, 1H,1'H-3,3'-biindole
TN716013637-37-1
3,3'-Bi[1H-indole] (3,3'-Biindole) is a marine derived natural products found in Nocardiopsis sp.
- $195
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Spiculisporic Acid
4,5-dicarboxy-4-pentadecanolide
T2828469-77-2
Spiculisporic Acid (4,5-dicarboxy-4-pentadecanolide) is a bioactive γ-butenolide isolated from a marine Aspergillus.
- $29
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Methyl mycophenolate Cited
Mycophenolic Acid Methyl Ester
T1942431858-66-9
Methyl mycophenolate (Mycophenolic Acid Methyl Ester) is found in the marine fungus Phaeosphaeria spartinae. Methyl mycophenolate is the methyl ester form of mycophenolic acid.
- $30
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Citedmethyl 5-bromo-1H-pyrrole-2-carboxylate
ZINC13379818
TN7174934-07-6
methyl 5-bromo-1H-pyrrole-2-carboxylate is a marine derived natural products found in Lissodendoryx sp.
- $29
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2-(4-Methoxyphenyl)-n-methyl-2-oxoacetamide
N-Methyl-2-(4-methoxyphenyl)-2-oxoacetamide, 2-(4-methoxy-phenyl)-N-methyl-2-oxo-acetamide
TN7158244264-57-1
2-(4-Methoxyphenyl)-n-methyl-2-oxoacetamide is a marine derived natural products found in Polycarpa aurata.
- $195
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