T11523 |
GZD856
|
1257628-64-0
|
98%
|
|
GZD856 is an orally bioavailable PDGFRα/β inhibitor (IC50s: 68.6 and 136.6 nM) with anti-lung cancer activities.
|
T1991 |
ZM323881 hydrochloride
|
193000-39-4
|
98%
|
|
ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
|
T13039 |
Sunitinib-d10
|
1126721-82-1
|
98%
|
|
Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ...
|
T13178 |
Toceranib
|
356068-94-5
|
98%
|
|
Toceranib phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PD...
|
T12145 |
N-Desethyl Sunitinib
|
356068-97-8
|
98%
|
|
N-Desethyl Sunitinib is a sunitinib metabolite.
|
T10228 |
AC710 Mesylate
|
1351522-05-8
|
98%
|
|
AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).
|
T35331 |
Dovitinib (TKI258) Lactate
|
|
98%
|
|
|
T12396 |
PDGFRα kinase inhibitor 1
|
2209053-93-8
|
98%
|
|
PDGFRα kinase inhibitor 1 is a highly selective inhibitor of type II PDGFRα kinase (PDGFRα and PDGFRβ with IC50s of 132 nM and 6115 nM , respectively).
|
TQ0080 |
SU14813 maleate
|
849643-15-8
|
98%
|
|
SU14813 maleate is an inhibitor of multi-targeted receptor tyrosine kinases (IC50s: 2, 50, 4, 15 nM for VEGFR1, VEGFR2, PDGFRβ, and KIT).
|
T6132 |
ENMD-2076 Tartrate
|
1291074-87-7
|
98%
|
|
ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more select...
|
T13156L |
TG 100572 Hydrochloride
|
867331-64-4
|
98%
|
|
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
|
T2372L |
Ponatinib Hydrochloride
|
1114544-31-8
|
98%
|
|
Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
|
T13238 |
Tyrphostin AG1433
|
168835-90-3
|
98%
|
|
Tyrphostin AG1433 (SU1433) is an inhibitor of tyrosine kinases, and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor (IC50s: 5.0 μM and 9.3 μM, respecti...
|
TQ0235 |
AC710
|
1351522-04-7
|
98%
|
|
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
|
T16947 |
SU16f
|
251356-45-3
|
98%
|
|
SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by S...
|
T11641 |
N-Desmethyl imatinib
|
404844-02-6
|
|
|
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
|
T14137 |
AG 1295
|
71897-07-9
|
|
|
AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR. But it can n...
|
T9030 |
SU4984
|
186610-89-9
|
100%
|
|
SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
|
T8402 |
Regorafenib Hydrochloride
|
835621-07-3
|
100%
|
|
Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor ac...
|
T3570 |
SU4312
|
5812-07-7
|
100%
|
|
SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexp...
|