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MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.
Cat. No. Product name CAS No. Purity Chemical Structure
T2610 BMS-599626 714971-09-2 98.73%
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T11993 MEK inhibitor 334951-92-7 98%
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
T10675 MEK-IN-1 870600-45-6 98%
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
TN1953 Morusinol 62949-93-3 98%
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
TN3525 Boehmenan 57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T15193 EBI-1051 1801896-05-8 98%
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
TN4166 Griffipavixanthone 219649-95-3 98%
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN5201 Uncarinic acid E 277751-61-8 98%
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN3711 Corylifol C 775351-91-2 98%
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
TN3397 Alpinumisoflavone 34086-50-5 98%
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
T13782 MS432 T13782 98%
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T14055 5Z-7-Oxozeaenol 253863-19-3 98%
5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...
T16114 Pavinetant 941690-55-7 98%
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
T22677 Cobimetinib racemate 934662-91-6 98%
GDC-0973 is a selective inhibitor of MEK. GDC-0973 is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathway.
T21332 U0126 109511-58-2 98%
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
TN1462 Cajanin 32884-36-9 98%
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
T6189 Mirdametinib 391210-10-9 99.91%
PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
T2327 Pelitinib 257933-82-7 99.86%
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T2416 BIX02189 1094614-85-3 99.86%
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T6152 PD318088 391210-00-7 99.81%
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...
BMS-599626
T2610
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
MEK inhibitor
T11993
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
MEK-IN-1
T10675
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
Morusinol
TN1953
Morusinol is a flavonoid extracted from the root bark of Morus alba. Morusinol has antiplatelet and anticancer activities, inhibits arterial thrombosis in vivo, ...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
EBI-1051
T15193
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
Griffipavixanthone
TN4166
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
Uncarinic acid E
TN5201
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
Corylifol C
TN3711
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
Alpinumisoflavone
TN3397
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
MS432
T13782
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
5Z-7-Oxozeaenol
T14055
5Z-7-Oxozeaenol, a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of...
Pavinetant
T16114
Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrom...
Cobimetinib racemate
T22677
GDC-0973 is a selective inhibitor of MEK. GDC-0973 is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathway.
U0126
T21332
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
Cajanin
TN1462
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
Mirdametinib
T6189
PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
Pelitinib
T2327
Pelitinib (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
BIX02189
T2416
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
PD318088
T6152
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-bi...
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