MEK

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.

Cat. No.	Product name	CAS No.	Purity
T2610	BMS-599626	714971-09-2	98%
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T11993	MEK inhibitor	334951-92-7	98%
MEK inhibitor is a potent MEK inhibitor with antitumor potency.
T7030	Anemarsaponin B	139051-27-7	98%
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
TN3397	Alpinumisoflavone	34086-50-5	98%
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
T10675	MEK-IN-1	870600-45-6	98%
MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.
T13782	MS432	T13782	98%
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
TN1462	Cajanin	32884-36-9	98%
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
TN3525	Boehmenan	57296-22-7	98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3711	Corylifol C	775351-91-2	98%
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
T15193	EBI-1051	1801896-05-8	98%
EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).
T16114	Pavinetant	941690-55-7	98%
Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R).
TN4166	Griffipavixanthone	219649-95-3	98%
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN5201	Uncarinic acid E	277751-61-8	98%
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
T7610	GW284543	790186-68-4	98%
GW284543 is a selective inhibitor of MEK5 .
T21980	PD 198306	212631-61-3	98%
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of ac...
T9321	Zapnometinib	303175-44-2
zapnometinib is a MEK inhibitor.
T21635	PD184161	212631-67-9
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].
T6636	Refametinib	923032-37-5	100%
Refametinib (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).
T6785	BI-847325	1207293-36-4	97.54%
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
T7742	GW 284543 hydrochloride	179246-08-3	98%
GW 284543 hydrochloride is a selective inhibitor of MEK5 .

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T2610

BMS-599626

714971-09-2

98%

BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.

T11993

MEK inhibitor

334951-92-7

98%

MEK inhibitor is a potent MEK inhibitor with antitumor potency.

T7030

Anemarsaponin B

139051-27-7

98%

Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...

TN3397

Alpinumisoflavone

34086-50-5

98%

Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...

T10675

MEK-IN-1

870600-45-6

98%

MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1.

T13782

MS432

T13782

98%

MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

TN1462

Cajanin

32884-36-9

98%

Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...

TN3525

Boehmenan

57296-22-7

98%

(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...

TN3711

Corylifol C

775351-91-2

98%

Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...

T15193

EBI-1051

1801896-05-8

98%

EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).

T16114

Pavinetant

941690-55-7

98%

Pavinetant is an antagonist of the neurokinin-3 receptor (NK3R).

TN4166

Griffipavixanthone

219649-95-3

98%

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...

TN5201

Uncarinic acid E

277751-61-8

98%

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...

T7610

GW284543

790186-68-4

98%

GW284543 is a selective inhibitor of MEK5 .

T21980

PD 198306

212631-61-3

98%

PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of ac...

T9321

Zapnometinib

303175-44-2

zapnometinib is a MEK inhibitor.

T21635

PD184161

212631-67-9

PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].

T6636

Refametinib

923032-37-5

100%