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Estrogen Receptor/ERR

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.There are three human estrogen related receptors:ERRα,ERRβand ERRγ .
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78676 ERα degrader 6 98%
ERα degrader 6
ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM. It effectively inhibits tumor growth in...
T78824 ERD-3111 2832865-25-3 98%
ERD-3111
ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft mo...
T79064 Estrogen receptor modulator 7 2639168-13-9 98%
Estrogen receptor modulator 7
Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].
T79109 Estrogen receptor modulator 8 2170766-56-8 98%
Estrogen receptor modulator 8
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) ...
T79382 ER degrader 6 2922929-62-0 98%
ER degrader 6
ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the micro...
T79573 ET receptor antagonist 1 98%
ET receptor antagonist 1
ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) ...
T79574 ET receptor antagonist 2 98%
ET receptor antagonist 2
ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH) re...
T79575 ET receptor antagonist 3 98%
ET receptor antagonist 3
"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) r...
T79736 14-3-3σ/ERα stabilizer-1 98%
14-3-3σ/ERα stabilizer-1
Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins. It is utilized in research as a molecular glue...
T82439 Estrogen receptor modulator 10 2991504-90-4 98%
Estrogen receptor modulator 10
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capabili...
T82722 CIDD-0149897 2862784-20-9 98%
CIDD-0149897
CIDD-0149897 is a potent, selective, and brain-penetrant agonist of ERβ that exhibits antitumor activity in glioblastoma [1].
T9455 4-hydroxyestrone-4-methyl ether 58562-33-7 98%
4-hydroxyestrone-4-methyl ether
4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) is the methylation of 4-OHE1, which is catalyzed by COMT.
T6404 Bazedoxifene hydrochloride 198480-56-7 98%
Bazedoxifene hydrochloride
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM an...
T6827 Endoxifen Z-isomer hydrochloride 1032008-74-4 98%
Endoxifen Z-isomer hydrochloride
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
TN3084 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 1353676-65-9 98%
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 val...
T0139 Toremifene 89778-26-7 98%
Toremifene
Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).
T9454 4-Hydroxyestrone 3131-23-5 98%
4-Hydroxyestrone
4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
T9997 GLL 398 2077980-80-2 98%
GLL 398
GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
T20419 Raloxifene 84449-90-1 98%
Raloxifene
Raloxifene (LY-139481) is a selective oestrogen receptor modulator. It has effects on bone and breast cancer and cardiovascular disease risk.
T0760 Cholesterol 57-88-5 99.94%
Cholesterol
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is w...
ERα degrader 6
T78676
ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM. It effectively inhibits tumor growth in...
ERD-3111
T78824
ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft mo...
Estrogen receptor modulator 7
T79064
Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].
Estrogen receptor modulator 8
T79109
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) ...
ER degrader 6
T79382
ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the micro...
ET receptor antagonist 1
T79573
ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) ...
ET receptor antagonist 2
T79574
ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH) re...
ET receptor antagonist 3
T79575
"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) r...
14-3-3σ/ERα stabilizer-1
T79736
Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins. It is utilized in research as a molecular glue...
Estrogen receptor modulator 10
T82439
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capabili...
CIDD-0149897
T82722
CIDD-0149897 is a potent, selective, and brain-penetrant agonist of ERβ that exhibits antitumor activity in glioblastoma [1].
4-hydroxyestrone-4-methyl ether
T9455
4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) is the methylation of 4-OHE1, which is catalyzed by COMT.
Bazedoxifene hydrochloride
T6404
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM an...
Endoxifen Z-isomer hydrochloride
T6827
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
TN3084
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 val...
Toremifene
T0139
Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).
4-Hydroxyestrone
T9454
4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.
GLL 398
T9997
GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
Raloxifene
T20419
Raloxifene (LY-139481) is a selective oestrogen receptor modulator. It has effects on bone and breast cancer and cardiovascular disease risk.
Cholesterol
T0760
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is w...
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TargetMol