Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Estrogen Receptor/ERR

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.There are three human estrogen related receptors:ERRα,ERRβand ERRγ .

ARV-471
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
  • $265
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Tamoxifen
T690610540-29-1
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
  • $39
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Fulvestrant
T2146129453-61-8
Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.
  • $42
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
4-Hydroxytamoxifen
T442068047-06-3
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer research.
  • $64
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Coumestrol
TQ0295479-13-0
Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.
  • $40
In Stock
Size
QTY
Kaempferol
T2177520-18-3
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
  • $46
In Stock
Size
QTY
TargetMol | Citations Cited
GSK5182
T8370877387-37-6
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
  • $48
In Stock
Size
QTY
Cholesterol
T076057-88-5
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
(E/Z)-4-Hydroxytamoxifen
T674368392-35-8
(E Z)-4-Hydroxytamoxifen (Afimoxifene) is a novel estrogen inhibitor, commonly used in research for various estrogen-dependent conditions, including cyclic mastalgia and gynecomastia.
  • $47
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Liquiritigenin
T3325578-86-9
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
  • $48
In Stock
Size
QTY
TargetMol | Citations Cited
Estradiol
T104850-28-2
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
  • $28
In Stock
Size
QTY
TargetMol | Citations Cited
Saikosaponin D
T391320874-52-6
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
  • $47
In Stock
Size
QTY
Camizestrant
T112372222844-89-3In house
Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1].
  • $158
In Stock
Size
QTY
Bazedoxifene acetate
T2544198481-33-3
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).
  • $39
In Stock
Size
QTY
TargetMol | Citations Cited
G-1
T15364881639-98-1
G-1 is a nonsteroidal, high-affinity, and selective GPR30 agonist (Ki: 11 nM).
  • $43
In Stock
Size
QTY
Giredestrant
T113991953133-47-5
Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.
  • $139
In Stock
Size
QTY
PHTPP
T4388805239-56-9
PHTPP is a selective ERβ antagonist.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Erteberel
T6306533884-09-2In house
Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
  • $156
In Stock
Size
QTY
Elacestrant
T13674722533-56-4
Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
  • $147
In Stock
Size
QTY
(Rac)-Acolbifene
T12654151533-34-5In house
(Rac)-Acolbifene (EM-343) is the racemic form of Acolbifene. Acolbifene is a estrogen receptor antagonist. (Rac)-Acolbifene exhibits anti-estrogenic and estrogenic activities. (Rac)-Acolbifene contains a piperidine ring and exhibits good pharmacological profile,relative binding affinity (RBA)=380.
  • $32
In Stock
Size
QTY
Delphinidin chloride
TN1567528-53-0
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 μM, epithelial growth factor receptor signaling and estrogen receptor α expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300 CBP (IC50 was about 30 μM).
  • $43
In Stock
Size
QTY
Amcenestrant
T128322114339-57-8
Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).
  • $147
In Stock
Size
QTY
Raloxifene hydrochloride
T154982640-04-8
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
  • $38
In Stock
Size
QTY
TargetMol | Citations Cited
Enclomiphene citrate
T73137599-79-3
Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic property
  • $48
In Stock
Size
QTY
Droloxifene
T1109882413-20-5In house
Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti-implantation effects.Fluroxifene prevented bone loss in ovariectomized rats.
  • $49
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Camizestrant TFA
T11237L In house
Camizestrant TFA (AZD-9833 TFA) is a potent and orally active antagonist of estrogen receptor (ER).
  • $98
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Pipendoxifene hydrochloride
T12482245124-69-0In house
Pipendoxifene hydrochloride is a selective modulator of estrogen receptor.
  • $48
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Premarin
T36857L481-97-0
Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.
  • $195
In Stock
Size
QTY
(-)-(S)-Equol
T6491531-95-3
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.
  • $43
In Stock
Size
QTY
AZD9496
T39751639042-08-2
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
  • $51
In Stock
Size
QTY
TargetMol | Inhibitor Sale
kaempferide
T3806491-54-3
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.
  • $80
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Genistin
T2882529-59-9
Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities
  • $60
In Stock
Size
QTY
Estradiol benzoate
T038450-50-0
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited
Diethylstilbestrol
T121656-53-1
Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders.
  • $48
In Stock
Size
QTY
Chrysin
T2837480-40-0
Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
  • $42
In Stock
Size
QTY
TargetMol | Citations Cited
Estradiol (cypionate)
T0168313-06-4
Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
  • $31
In Stock
Size
QTY
Propyl pyrazole triol
T16566263717-53-9
Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha (ERα), exhibiting a relative binding affinity of 49% for ERα, which is approximately 410 times higher than its affinity for estrogen receptor beta (ERβ: 0.12%).
  • $38
In Stock
Size
QTY
DY131
T225095167-41-2
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.
  • $47
In Stock
Size
QTY
TargetMol | Inhibitor Sale
XCT790
T0593725247-18-7
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
  • $59
In Stock
Size
QTY
Norethindrone acetate
T4059851-98-9
Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in combination with progestins in the study of endometriosis.
  • $30
In Stock
Size
QTY
(20S)-Protopanaxatriol
T281034080-08-5
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
  • $53
In Stock
Size
QTY
TargetMol | Inhibitor Sale
α-Zearalenol
T1354236455-72-8
α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).
  • $108
In Stock
Size
QTY
MPP hydrochloride
T21897L
MPP hydrochloride is a selective estrogen receptor (ERR) modulator.
  • $135
In Stock
Size
QTY
Isocurcumenol
T5S054324063-71-6
1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).
  • $64
In Stock
Size
QTY
Ethynyl estradiol
T142457-63-6
Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
  • $32
In Stock
Size
QTY
TargetMol | Citations Cited
Endoxifen (E-isomer)
T11200114828-90-9
Endoxifen E-isomer (E-Endoxifen) is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Brilanestrant
T51181365888-06-7
Brilanestrant (GDC-0810) is a selective estrogen receptor degrader (IC50: 0.7 nM).
  • $48
In Stock
Size
QTY
TargetMol | Citations Cited
Clomiphene citrate
T119350-41-9
Clomiphene citrate (NSC 35770) is a selective estrogen receptor modulator.
  • $45
In Stock
Size
QTY
TargetMol | Citations Cited