ro 3

RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor

Ro 3-5940 HCl is a psychoactive agent, increasing in production of serotonin in central nervous system tissue.

Ro 3-7410 is an active hydroxy metabolite of bufuralol.

Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.

2-Chloro 3,5-dimethyl pyarazine ,with CAS No. 38557-72-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Chloro 3,5-dimethyl pyarazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Ro 31-8220 formic is a potent inhibitor of protein kinase C (PKC), specifically targeting PKCα, PKCβI, PKCβII, PKCγ, PKCε, and rat brain PKC, with IC50 values of 5, 24, 14, 27, 24, and 23 nM, respectively. It also inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β, with IC50 values of 3, 8, 15, and 38 nM. Additionally, Ro 31-8220 formic suppresses the expression of MKP-1, induces c-Jun expression, and activates JNK, exhibiting these effects through mechanisms independent of PKC.

Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.

Ro 31-8220 is a potent inhibitor of PKC with IC50 values of 5, 24, 14, 27, 24, and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε, and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β with IC50 values of 3, 8, 15, and 38 nM, respectively, without affecting MKK3, MKK4, MKK6, and MKK7.

Ro 31-9790, a synthetic inhibitor of metalloproteinase (MMP), is designed to target and inhibit the action of MMP enzymes.

RO 363 is an effective inotropic stimulant and is a cardiovascular modulator that decreases diastolic blood pressure and pronounces increases in myocardial contractility. Ro 363 is an effective and highly selective β1-adrenoceptor agonist.

Ro 32-0432 is a selective, ATP-competitive, orally active pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε. It blocks T-cell activation and may be employed in inflammatory and immune disorders. (S)-Ro 32-0432 hydrochloride is a GRK5 (G protein-coupled receptor kinase 5) inhibitor that alleviates nicotine withdrawal symptoms.

Ro 32-7315 is a selective inhibitor of ADAM17.

Ro 31-1118 is a partial agonist of beta-adrenoceptor.

Ro 31-2201 is a potent inhibitor of angiotensin converting enzyme.

Ro 31-4639 is a phospholipase A2 inhibitor in vitro.

Ro 31-7837 is an opener of potassium channel.

Ro 31-8472 is an angiotensin-converting enzyme (ACE) inhibitor and an analog of cilazaprilat.

Talviraline is a RNA-directed DNA polymerase inhibitor. HBY 097 is a highly potent inhibitor of HIV-1 replication and HIV-1 induced cell killing in a variety of human cell lines as well as in fresh human peripheral blood lymphocytes and macrophages.

Ro 31-8830, a derivative of Ro 31-8425, has in vivo anti-inflammatory activity.

Ro 31-0052 is a bioactive chemical.

Ro 31-0313 is a metabolite of Ro 03-8799, radiation sensitizing agent.

Ro 31-8875 is a biochemical.

Mycro 3 is potent and selective for c-Myc in whole cell assays.

Ro 363 hydrochloride is an effective, highly selective agonist of β 1-adrenoceptor. Ro 363 hydrochloride is an effective inotropic stimulant. Ro 363 hydrochloride is a cardiovascular regulator, which can reduce diastolic blood pressure and significantly increase myocardial contractility.