nucleic acid

DMG-PEG 2000 (DMG-PEG2000) can be used for the preparation of lipid nanoparticles for the in vivo delivery of plasmid DNA via oral administration, enhancing the mucosal permeability and delivery efficiency of the nanoparticles. DMG-PEG 2000 can be used for the preparation of liposomes for siRNA transfection, improving transfection efficiency.

Locked nucleic acid 1 is an LNA-type nucleoside derivative.

Deoxyribonucleic Acid Sodium (Salmon testes) is a natural DNA used in studies of DNA binding agents that modulate DNA structure and function.

Ribonucleic Acid, Transfer from Brewing yeast (RNA) is a vital biomacromolecule, a polymer composed of covalently linked ribonucleotides, playing a pivotal role in processes such as protein synthesis and gene regulation.

Deoxyribonucleic acid (DNA) is a polymer formed by two polynucleotide chains winding into a double helix structure, with a backbone composed of alternating deoxyribose and phosphate groups. Deoxyribonucleic acid constitutes the fundamental component of chromosomes, serving as the molecular carrier of genetic information governing organismal development and function.

Deoxyribonucleic acid sodium salt from salmon testes (ssstDNA) is a DNA sodium salt derived from salmon testes. It is commonly used for surface modification of biomaterials to construct anti-fouling layers, passivate gold surfaces, and reduce non-specific adsorption, thereby improving the performance of sensors such as Surface plasmon resonance.

Deoxyribonucleic acid, single stranded from salmon testes, is a sodium salt form of DNA derived from salmon testes. It is utilized in basal media to support the anaerobic growth of various Bacillus mojavensis strains. Additionally, it serves as a substrate for the development of DNA detection assays.

Ribonucleic acid (yeast) is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Calf thymus DNA (DNA from calf thymus, thymonucleic acid) is a high-quality double-stranded template DNA extracted from bovine thymus. Calf thymus DNA (DNA from calf thymus, thymonucleic acid) is widely applicable in research on DNA-binding anticancer agents, DNA structure and function, and DNA-binding agents.

Epimedokoreanin B is a natural isopentenylflavonoid compound isolated from Korean horny goat weed (Epimedium koreanum Nakai) that exhibits anticancer, anti-inflammatory, and antibacterial activities. Epimedokoreanin B is an anti-periodontitis agent that inhibits the growth and biofilm formation of gingival proteases and Porphyromonas gingivalis. Epimedokoreanin B can inhibit the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagy.

Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.

Lipid A-11 is a lipid component of endotoxin that is primarily responsible for the toxic properties of gram-negative bacteria. Lipid A-11 constitutes the innermost region of the lipopolysaccharide (LPS) molecule, also known as endotoxin, and its hydrophobic nature facilitates anchoring of the LPS structure into the bacterial outer membrane. Lipid A-11 plays a critical role in host-pathogen interactions, contributing to septic shock and immunological activation during bacterial infections.

Xanthine oxidase-IN-1 is an effective inhibitor of xanthine oxidase with an IC50 value of 6.5 nM. It plays a central role in purine catabolism through the degradation of bioactive nucleotides facilitated by nucleic acid and nucleotide intermediates.

Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.

DC 07090 is a human enterovirus 71 3C protease inhibitor with antiviral activity for the study of nucleic acid virus infections.

6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

5-Fluorouridine is a metabolite of 5-fluorouracil that inhibits rRNA synthesis in human colon cancer cells and exhibits antitumor and antiviral activity. 5-Fluorouridine exerts a cytotoxic effect on the growth of L1210 cells, with an IC₅₀ value of 2 nM. 5-Fluorouridine binds to poly-A RNA and exhibits antiproliferative activity. 5-Fluorouridine can be used in studies of nucleic acid metabolism, cancer chemotherapy, and viral replication mechanisms.

Hypoxanthine (Purin-6-ol), also known as purine-6-ol or Hyp. Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the nucleotide salvage pathway. Under normal circumstances hypoxanthine is readily converted to uric acid.hypoxanthine is first oxidized to xanthine, which is further oxidized to uric acid by xanthine oxidase.

Phenanthridine is a nitrogen-containing heterocyclic compound. Phenanthridine serves as the structural backbone of fluorescent dyes that bind to DNA, enabling visualization of nucleic acid positions post-electrophoresis, as seen with dyes like ethidium bromide and propidium iodide. Acridine is an isomer of Phenanthridine. Used in ecotoxicological studies. Employed in rotational spectroscopy and radio astronomy research. Functions as a dye in biological and chemical sensors.

Maleic hydrazide is a plant growth regulator and germination inhibitor that participates in nucleic acid metabolism pathways within plants, thereby inhibiting cell division in the apical meristem.

6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

2'-Deoxyguanosine 5'-monophosphate disodium (5'-dGMP disodium) is a GTP derivative that serves as an oxidizable target and is used in forming polycomplexes with other compounds.

Glycerophospholipids, cephalins (Phosphatidylethanolamines (egg)) are a mixture of phosphatidylethanolamines isolated from eggs, with various fatty acyl groups at the sn-1 and sn-2 positions. Glycerophospholipids and cephalins can be completely hydrolyzed to obtain 1 mol of glycerol, phosphoric acid, ethanolamine and 2 mol of fatty acids. Phosphatidylethanolamines play a role in membrane fusion and disassembly of contractile rings during cell division, regulating membrane curvature. Phosphatidylethanolamines are able to transmit infectious prions without the help of any proteins or nucleic acids. One of the main roles of Phosphatidylethanolamines in bacterial membranes is to disperse the negative charges caused by anionic membrane phospholipids.

2′-Deoxyadenosine 5′-monophosphate disodium (a nucleic acid AMP derivative) is a deoxyribonucleotide in DNA, used for studying adenosine-based interactions in DNA synthesis and damage analysis.