cd28

T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 18-153, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: ELISA、SPR

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: BLI

Expression system: HEK293 Cells
Length: 18-153, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-152, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-152, Extracellular Domain
Activity: BLI

CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.6 kDa and the accession number is Q0PDN3.

CD28 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is A6IPD4.

CD28 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.8 kDa and the accession number is P31041.

CD28 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q0PDN3.

Expression system: HEK293 Cells
Length: 1-152, Extracellular Domain
Activity: ELISA

CD28 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is P31041.

Expression system: HEK293 Cells
Length: 1-152, Extracellular Domain
Activity: Not Tested

CD28 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is P31041.

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7 CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy.

Expression system: HEK293 Cells
Length: 1-150, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-150, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-150, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 20-220, Partial
Activity: SPR

Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. B7-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.8 kDa and the accession number is P33681-1.

B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.4 kDa and the accession number is G7NXR4.