Search Result

Search Results for " cardioprotective "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T21640	Talinolol		Adrenergic Receptor
	(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.		Adrenergic Receptor
T1940	BTB06584		RAAS , ATPase
	BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).		RAAS , ATPase
T24109	GSK329	GSK 329,GSK-329	Others
	GSK329 is an effective and selective inhibitor of TNNI3 Interacting Kinase (TNNI3K). GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury.		Others
T21919	UCF 101		Apoptosis
	UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.		Apoptosis
T9714	Atpenin A5		Potassium Channel
	Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1].		Potassium Channel
T0075	Nicorandil	SG-75	Potassium Channel
	Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b...		Potassium Channel
T12478L	Pinacidil	S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel
	Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.		Potassium Channel
T19335	Danegaptide Hydrochloride	GAP-134 (Hydrochloride),ZP 1609 Hydrochloride	Gap Junction Protein
	Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.		Gap Junction Protein
T25859	Necrostatin-7	Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis
	Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.		Apoptosis
T8493	Ingliforib	GPi 296,CP 368296	Phosphorylase
	Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties.		Phosphorylase
T10874	CP-060		Calcium Channel
	CP-060 is a potent Ca2+ antagonist and inhibits Ca2+ overload with antioxidant and cardioprotective activities.		Calcium Channel
T6454	CORM-3	CORM3	Others , NF-κB , NOD-like Receptor (NLR)
	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.		Others , NF-κB , NOD-like Receptor (NLR)
T68077	Furnidipine
	Furnidipine significantly reduced AoD and AF and had antiarrhythmic and cardioprotective effects at low doses in a rat model.
T7845	BTZO-1		Apoptosis
	BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.		Apoptosis
T75098	HIF-PHD-IN-3		Reactive Oxygen Species
	HIF-PHD-IN-3 is a potent hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.		Reactive Oxygen Species
T16420	P-1075		Potassium Channel
	P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c...		Potassium Channel
T16812	RWJ-67657	JNJ 3026582	p38 MAPK
	RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect.		p38 MAPK
T24270	KS370G	KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s...
T14506	BAY 60-6583		Others , Adenosine Receptor
	BAY 60-6583 is a potent, high-affinity adenosine A2B receptor agonist (EC50 = 3 nM) with affinity for A2B receptors that exceeds that for A1, A2A, and A3 receptors.BAY 60-6583 is cardioprotective in a model of myocardial...		Others , Adenosine Receptor
T36569	KR-32568		Sodium Channel
	KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated i...		Sodium Channel
T69097	ARD-353
	ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects.
T26842	Bms 188107	Bms188107,Bms-188107
	Bms 188107 is a calcium antagonist, it has cardioprotective effects.
T28656	Sabiporide	BIIB 722CL
	Sabiporide is a NHE-1 inhibitor and a cardioprotective agent.
T30487	BMS 180448	BMS-180448,BMS180448
	BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.
T11732	JTV-519 hemifumarate	K201 hemifumarate	MELK
	JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.		MELK
T12708	Resveratrol analog 1		Others
	Resveratrol analog 1 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.		Others
T12709	Resveratrol analog 2		Others
	Resveratrol analog 2 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.		Others
T37252	Chitoheptaose heptahydrochloride
	Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic, and cardioprotective properties. It effectively promotes the growth and photosynthesis parameters of whea...
T11731	JTV-519 free base	K201 free base	FLT
	JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partia...		FLT
T37807	JTV 519 fumarate
	Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]r...
T31191L	Dagapamil	Dagapamilum
	Dagapamil hydrochloride is a calcium-channel blocker. Dagapamil hydrochloride is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal model...
T31191	Dagapamil hydrochloride
	Dagapamil hydrochloride is a calcium-channel blocker. Dagapamil hydrochloride is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal model...
T28400	Phenoprolamine Hydrochloride	phenoprolamine,DDPH
	Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-r...
T61540	F15845
	F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarctio...
T78092	UCL-TRO-1938		PI3K
	UCL-TRO-1938, a potent allosteric activator of PI3Kα, exhibits an EC50 of approximately 60 μM. This compound promotes cell proliferation and possesses both cardioprotective and neural regeneration effects [1].		PI3K
T80070	PKCβII Peptide Inhibitor I		PKC
	PKCβII Peptide Inhibitor I, a specific PKCβII inhibitor, exhibits cardioprotective properties in a rat cardiac ischemia/reperfusion injury model and mitigates vascular endothelial dysfunction [1].		PKC
T62288	AD013
	AD013 is a dual cACE and NEP inhibitor. AD013 is a C-domain selective ACE inhibitor of lenopril-tryptophan synthesis. AD013 has the potential to provide potent anti-hypertensive and cardioprotective effects.
T63160	AD011
	AD011 is a dual cACE/NEP inhibitor. AD011 was synthesized via the previously reported C-domain selective ACE inhibitor lenopril-tryptophan. AD011 shows potential to provide potent anti-hypertensive and cardioprotective e...
T76191	GLP-1(28-36)amide TFA
	GLP-1(28-36)amide TFA, a C-terminal nonapeptide derived from GLP-1 cleavage by neutral endopeptidase (NEP), acts as an antioxidant targeting mitochondria. It inhibits mitochondrial permeability transition (MPT), exhibiti...
T11731L	JTV-519 Formate	JTV-519 Formate (145903-06-6 Free base)	Others , Calcium Channel
	JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrh...		Others , Calcium Channel
T62831	AD012
	AD012 is a dual inhibitor of cACE/NEP. AD012 utilises the previously reported C-domain selective ACE inhibitor lenopril-tryptophan synthesis. AD012 has the potential to provide potent anti-hypertensive and cardioprotecti...
T60276	Cyclocreatine phosphate
	Cyclocreatine phosphate is an anti-tumor agent. Cyclocreatine phosphate(CCrP) is the proposed active form of cyclocreatine (CCr), a substrate analogue of creatine kinase. Cyclocreatine and its water-soluble derivative, c...
T37297	Ru360
	Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondr...
T71910	Racemic rasagiline
	Racemic rasagiline, also known as AGN-1135, is a Monoamine Oxidase type-B inhibitor (MAOI). However, application of this drug can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods. TVP-102...
TP1965	Parstatin(human)	Parstatin (human)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation...
TP1966	Parstatin(mouse)	Parstatin (mouse)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activatio...
T68499	F15845 HBr
	F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotect...
T37496	Alamandine
	Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). H...
T60713	TK-129
	TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used...
T81485	Phoenixin-14 TFA	PNX-14 TFA
	Phoenixin-14 TFA (PNX-14) is a blood-brain barrier (BBB)-penetrable neuropeptide with anxiolytic, cardioprotective, and neuroprotective properties. It modulates pituitary gonadotrophin release by enhancing gonadotropin-r...

Compounds

Talinolol

T21640

Synonym:

Target: Adrenergic Receptor

Synonym: GSK 329,GSK-329

Target: Potassium Channel

Nicorandil

T0075

Synonym: SG-75

Target: Potassium Channel

Pinacidil

T12478L

Synonym: S 1230,P 1134,S-1230,P-1134,P1134

Target: Potassium Channel

Danegaptide Hydrochloride

T19335

Synonym: GAP-134 (Hydrochloride),ZP 1609 Hydrochloride

Target: Gap Junction Protein

Necrostatin-7

T25859

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Target: Apoptosis

Ingliforib

T8493

Synonym: GPi 296,CP 368296

Target: Phosphorylase

CP-060

T10874

Synonym:

Target: Calcium Channel

CORM-3

T6454

Synonym: CORM3

Target: Others, NF-κB, NOD-like Receptor (NLR)

Target: Reactive Oxygen Species

P-1075

T16420

Synonym:

Target: Potassium Channel

Synonym: KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide

Target: Others, Adenosine Receptor

KR-32568

T36569

Synonym:

Target: Sodium Channel

Synonym: Bms188107,Bms-188107

Synonym: BMS-180448,BMS180448

Target:

JTV-519 hemifumarate

T11732

Synonym: K201 hemifumarate

Chitoheptaose heptahydrochloride

Synonym: K201 free base

Dagapamil hydrochloride

T31191

Synonym:

Target:

Phenoprolamine Hydrochloride

T28400

Synonym: phenoprolamine,DDPH

PKCβII Peptide Inhibitor I

GLP-1(28-36)amide TFA

Synonym: JTV-519 Formate (145903-06-6 Free base)

Target: Others, Calcium Channel

Cyclocreatine phosphate

Synonym: Parstatin (human)

Target:

Parstatin(mouse)

TP1966

Synonym: Parstatin (mouse)

Cat No.	Product Name	Synonyms	Targets
T3809	Liriope muscari baily saponins C		Others
	Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6.		Others
TN2144	Resveratroloside		P450 , NO Synthase
	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.		P450 , NO Synthase
T2763	Panaxadiol	20(R)-Panaxadiol	Others , HIF/HIF Prolyl-Hydroxylase
	Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.		Others , HIF/HIF Prolyl-Hydroxylase
TN1982	Neoglycyrol		Others
	Neoglycyrol shows some cardioprotective effects .		Others
T3885	ROSIRIDIN	6'-O-Deacetylrosiridoside C,(-)-Rosiridin	Others , Monoamine Oxidase
	Rosiridin (6'-O-Deacetylrosiridoside C) has cardioprotective activity.		Others , Monoamine Oxidase
T5S0833	Astragaloside III		Antioxidant
	Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant.		Antioxidant
T3735	Tetrahydrocurcumin	Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin	P450 , Endogenous Metabolite , Autophagy
	Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.		P450 , Endogenous Metabolite , Autophagy
T6S1101	Astragalin	Kaempferol 3-D-glucoside,Kaempferol 3-O-glucoside,kaempferol-3-glucoside,3-Glucosylkaempferol,Astragaline,Kaempferol 3-β-D-glucopyranoside	Apoptosis , NF-κB
	Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotecti...		Apoptosis , NF-κB
TQ0207	Sulforaphane		Apoptosis , Nrf2 , HDAC
	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.		Apoptosis , Nrf2 , HDAC
TN1182	11-Keto-beta-boswellic acid	11-Keto-beta-boswellic acid	Leukotriene Receptor , NF-κB , Lipoxygenase
	11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas...		Leukotriene Receptor , NF-κB , Lipoxygenase
TN1065	Hirsutine		Apoptosis
	Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti...		Apoptosis
T4518	Licochalcone D		ERK , NF-κB
	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...		ERK , NF-κB
T4749	Squalene	Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene	Reactive Oxygen Species , Endogenous Metabolite , Antifungal
	Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All hi...
TN1969	N-(p-Coumaroyl) serotonin		PDGFR
	N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving...		PDGFR
T3S1553	Trans-Cinnamaldehyde	Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein	COX , Endogenous Metabolite
	1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...		COX , Endogenous Metabolite
T40586	Neophytadiene
	Neophytadiene, a diterpene discovered in Turbinaria ornate, showcases desirable bioactive properties including anti-inflammatory, antioxidant, and cardioprotective effects.
TN1642	Ferruginol		BCL , PARP , Caspase
	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.		BCL , PARP , Caspase
TN1412	Astringin	trans-Astringin	IL Receptor , Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be corre...		IL Receptor , Others
T75531	Ladanetin-6-O-β-D-glucopyranoside
	Ladanetin-6-O-β-D-glucopyranoside, an active flavonoid, exhibits antioxidative effects and has potential for research into cardioprotective effects [1].
T77201	Rutin trihydrate
	Rutin (Rutoside) trihydrate, a natural flavonoid glycoside, exhibits multifaceted therapeutic properties, including antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic activities. Additionally, it has de...
TN1431	Baohuoside VII		Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VI...		Others
T81956	Ladanetin-6-O-β-(6′′-O-acetyl)glucoside
	Ladanetin-6-O-β-(6′′-O-acetyl)glucoside, a flavonoid extracted from Dracocephalum tanguticum whole plants, exhibits antioxidant properties and cardioprotective effects, mitigating Doxorubicin-induced toxicity in H9c2 cel...
T8291	2-Carene		Others
	2-Carene is a naturally occurring bicyclic monoterpene found in many essential oils such as pine, cedar and cypress. It has been found to have anti-inflammatory, antifungal and antibacterial activities, as well as antiox...		Others

Natural Products

Liriope muscari baily saponins C

Target: P450, NO Synthase

Panaxadiol

T2763

Synonym: 20(R)-Panaxadiol

Target: Others, HIF/HIF Prolyl-Hydroxylase

Synonym: 6'-O-Deacetylrosiridoside C,(-)-Rosiridin

Target: Others, Monoamine Oxidase

Synonym: Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin

Target: P450, Endogenous Metabolite, Autophagy

Astragalin

T6S1101

Synonym: Kaempferol 3-D-glucoside,Kaempferol 3-O-glucoside,kaempferol-3-glucoside,3-Glucosylkaempferol,Astragaline,Kaempferol 3-β-D-glucopyranoside

Target: Apoptosis, NF-κB

Sulforaphane

TQ0207

Synonym:

Target: Apoptosis, Nrf2, HDAC

11-Keto-beta-boswellic acid

TN1182

Synonym: 11-Keto-beta-boswellic acid

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

Synonym: Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene

Target: Reactive Oxygen Species, Endogenous Metabolite, Antifungal

N-(p-Coumaroyl) serotonin

Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Target: BCL, PARP, Caspase

Astringin

TN1412

Synonym: trans-Astringin

Target: IL Receptor, Others

Ladanetin-6-O-β-D-glucopyranoside

Ladanetin-6-O-β-(6′′-O-acetyl)glucoside

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00734	KNG1 Protein, Human, Recombinant (His)	Human	Human Cells
	Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ...

KNG1 Protein, Human, Recombinant (His)

TMPJ-00734

Species: Human

Expression System: Human Cells

Cat No.	Product Name
L6100	Polyphenolic Natural Product Library		640 compounds
	A unique collection of 640 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS);

Libraries

Polyphenolic Natural Product Library

L6100

Compounds: 640