sirtuin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12922	Sirtuin modulator 1	SRT3025 Hydrochloride	Sirtuin
	Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.		Sirtuin
T9999	Sirtuin modulator 2	N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others , Sirtuin
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.		Others , Sirtuin
T79903	Sirtuin-1 inhibitor 1		Sirtuin
	Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.		Sirtuin
T6679	SRT 2104	SRT2104,sirtuin modulator,GSK2245840	Sirtuin
	SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.		Sirtuin
T72483	Sirtuin modulator 4
	Sirtuin Modulator 4, a sirtuin modulator, exhibits an inhibitory effect on SIRT1, presenting an EC 50 value ranging from 51-100 μM. It is potentially useful in research aimed at prolonging cell lifespan and preventing a ...
T74672	Sirtuin modulator 5
	Sirtuin Modulator 5, a sirtuin modulating agent, activates SIRT1 with an efficacy marked by a DC50 value of less than 50 μM. It is applicable in enhancing cell longevity and is researched for its therapeutic potential in...
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T3447	Thiomyristoyl		Sirtuin
	Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.		Sirtuin
T3953	Salermide		Apoptosis , Sirtuin
	Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.		Apoptosis , Sirtuin
TN1071	Ophiopogonin D'		Sirtuin , UGT
	Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.		Sirtuin , UGT
T12919	SIRT-IN-2		Sirtuin
	SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).		Sirtuin
T1887	Inauhzin	INZ	Sirtuin
	Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...		Sirtuin
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T6984	SirReal2		Sirtuin
	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.		Sirtuin
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T12918	SIRT-IN-1		Sirtuin
	SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).		Sirtuin
T5490	AK-7		Sirtuin
	AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.		Sirtuin
T7679	UBCS039		Sirtuin , Autophagy
	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)		Sirtuin , Autophagy
T9648	SIRT1-IN-1		Antiviral , Sirtuin
	SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity.		Antiviral , Sirtuin
T4062	CAY10602		Sirtuin
	CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende...		Sirtuin