Home Tools
Log in
Cart

Search Result

Search Results for " sirtuin "

Targets

55

Compounds

12

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12922 Sirtuin modulator 1 SRT3025 Hydrochloride Sirtuin
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.
T9999 Sirtuin modulator 2 N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide Others , Sirtuin
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.
T79903 Sirtuin-1 inhibitor 1 Sirtuin
Sirtuin-1 Inhibitor 1 (Compound 8) is a compound that impedes Sirtuin-1, a protein implicated in obesity-induced diabetes and aging-associated diseases [1].
T6679 SRT 2104 SRT2104,sirtuin modulator,GSK2245840 Sirtuin
SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T72483 Sirtuin modulator 4
Sirtuin Modulator 4, a sirtuin modulator, exhibits an inhibitory effect on SIRT1, presenting an EC 50 value ranging from 51-100 μM. It is potentially useful in research aimed at prolonging cell lifespan and preventing a ...
T74672 Sirtuin modulator 5
Sirtuin Modulator 5, a sirtuin modulating agent, activates SIRT1 with an efficacy marked by a DC50 value of less than 50 μM. It is applicable in enhancing cell longevity and is researched for its therapeutic potential in...
T21679 4'-bromo-Resveratrol Sirtuin
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
T3447 Thiomyristoyl Sirtuin
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T3953 Salermide Apoptosis , Sirtuin
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T12919 SIRT-IN-2 Sirtuin
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
T1887 Inauhzin INZ Sirtuin
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...
T6984 SirReal2 Sirtuin
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T22026 AGK7 Others , Sirtuin
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).
T12918 SIRT-IN-1 Sirtuin
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T5618 AK-1 Sirtuin
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
T5490 AK-7 Sirtuin
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
T7679 UBCS039 Sirtuin , Autophagy
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T9648 SIRT1-IN-1 Antiviral , Sirtuin
SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity.
T4062 CAY10602 Sirtuin
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende...
T16932 SRT 2183 Apoptosis , Sirtuin
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T39233 SIRT7 inhibitor 97491 Sirtuin
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
T1919 Tenovin-1 Tenovin 1 Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T1818 Tenovin-6 Tenovin 6 Dehydrogenase , Sirtuin , Autophagy
Tenovin-6 is a p53 transcriptional activity agonist.
T4019 Cambinol SIRT1/2 Inhibitor IV,NSC 112546 Apoptosis , Phospholipase , Sirtuin
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca...
T8480 Tenovin-6 Hydrochloride Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
T6671 Sirtinol Apoptosis , Sirtuin , Autophagy
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T9998 MIND4-19 Sirtuin
MIND4-19 is an inhibitor of SIRT2 with antitumor activity.
T15263 Selisistat R-enantiomer EX-527 (R-enantiomer) Sirtuin
Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).
T4328 OSS_128167 SIRT6-IN-1 HBV , Sirtuin
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T4108 3-TYP 3-(1H-1,2,3-triazol-4-yl) pyridine Sirtuin
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
T6111 Selisistat EX-527,SEN0014196 Sirtuin
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.
T6371 AGK2 Apoptosis , Sirtuin
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
T5096 SRT 1720 Sirtuin , Autophagy
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T8346 SRT 1460 SRT1460 Sirtuin
SRT 1460 is a SIRT1 activator.
T7058 Selisistat S-enantiomer EX-527 S-enantiomer,EX-527 (S-enantiomer) Sirtuin
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.
T9320 YK-3-237 B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid Sirtuin
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca...
T22595 B2 Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline Others , Sirtuin
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
T2160 Suramin Sodium Salt BAY-205,Suramin hexasodium salt,NF-060 Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T12921 SIRT5 inhibitor 1 Sirtuin
SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases.
T12920 Sirt2-IN-1 Sirtuin
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).
T77653 Z26395438 Sirtuin
Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.
T60064 WAY-270360 N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide EGFR , Sirtuin
WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.
T60001 Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) 3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide Sirtuin
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or pre...
Fr13587 7-Chloro-4-(piperazin-1-yl)quinoline
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles. 7-Chloro-4-(piperazin-1-yl)q...
T15610 JFD00244 Others
JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.
T26259 Tenovin-D3 TenovinD3
Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.
T80813 WAY-354574 Sirtuin
WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].
T18641 SirReal1-O-propargyl PROTAC Sirt2-binding moiety 1 Others
SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates by binding to the cereblon ligand through a linker, facilita...
T78857 SIRT5 inhibitor 9 Sirtuin
SIRT5 inhibitor 9 (compound 14), with an IC50 of 4.07 μM, is a competitive inhibitor of the sirtuin SIRT5, exhibiting potential anticancer properties [1].
T78856 SIRT5 inhibitor 8 Sirtuin
SIRT5 inhibitor 8 (compound 10) serves as a competitive inhibitor of sirtuin SIRT5, exhibiting an IC50 of 5.38 μM, and possesses anticancer potential [1].

Compounds

Sirtuin modulator 1
T12922
Synonym: SRT3025 Hydrochloride
Target: Sirtuin
Sirtuin modulator 2
T9999
Synonym: N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide
Target: Others, Sirtuin
Sirtuin-1 inhibitor 1
T79903
Synonym:
Target: Sirtuin
SRT 2104
T6679
Synonym: SRT2104,sirtuin modulator,GSK2245840
Target: Sirtuin
Sirtuin modulator 4
T72483
Synonym:
Target:
Sirtuin modulator 5
T74672
Synonym:
Target:
4'-bromo-Resveratrol
T21679
Synonym:
Target: Sirtuin
Thiomyristoyl
T3447
Synonym:
Target: Sirtuin
Salermide
T3953
Synonym:
Target: Apoptosis, Sirtuin
SIRT-IN-2
T12919
Synonym:
Target: Sirtuin
Inauhzin
T1887
Synonym: INZ
Target: Sirtuin
SirReal2
T6984
Synonym:
Target: Sirtuin
AGK7
T22026
Synonym:
Target: Others, Sirtuin
SIRT-IN-1
T12918
Synonym:
Target: Sirtuin
AK-1
T5618
Synonym:
Target: Sirtuin
AK-7
T5490
Synonym:
Target: Sirtuin
UBCS039
T7679
Synonym:
Target: Sirtuin, Autophagy
SIRT1-IN-1
T9648
Synonym:
Target: Antiviral, Sirtuin
CAY10602
T4062
Synonym:
Target: Sirtuin
SRT 2183
T16932
Synonym:
Target: Apoptosis, Sirtuin
SIRT7 inhibitor 97491
T39233
Synonym:
Target: Sirtuin
Tenovin-1
T1919
Synonym: Tenovin 1
Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy
Tenovin-6
T1818
Synonym: Tenovin 6
Target: Dehydrogenase, Sirtuin, Autophagy
Cambinol
T4019
Synonym: SIRT1/2 Inhibitor IV,NSC 112546
Target: Apoptosis, Phospholipase, Sirtuin
Tenovin-6 Hydrochloride
T8480
Synonym:
Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy
Sirtinol
T6671
Synonym:
Target: Apoptosis, Sirtuin, Autophagy
MIND4-19
T9998
Synonym:
Target: Sirtuin
Selisistat R-enantiomer
T15263
Synonym: EX-527 (R-enantiomer)
Target: Sirtuin
OSS_128167
T4328
Synonym: SIRT6-IN-1
Target: HBV, Sirtuin
3-TYP
T4108
Synonym: 3-(1H-1,2,3-triazol-4-yl) pyridine
Target: Sirtuin
Selisistat
T6111
Synonym: EX-527,SEN0014196
Target: Sirtuin
AGK2
T6371
Synonym:
Target: Apoptosis, Sirtuin
SRT 1720
T5096
Synonym:
Target: Sirtuin, Autophagy
SRT 1460
T8346
Synonym: SRT1460
Target: Sirtuin
Selisistat S-enantiomer
T7058
Synonym: EX-527 S-enantiomer,EX-527 (S-enantiomer)
Target: Sirtuin
YK-3-237
T9320
Synonym: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
Target: Sirtuin
B2
T22595
Synonym: Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
Target: Others, Sirtuin
Suramin Sodium Salt
T2160
Synonym: BAY-205,Suramin hexasodium salt,NF-060
Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite
SIRT5 inhibitor 1
T12921
Synonym:
Target: Sirtuin
Sirt2-IN-1
T12920
Synonym:
Target: Sirtuin
Z26395438
T77653
Synonym:
Target: Sirtuin
WAY-270360
T60064
Synonym: N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide
Target: EGFR, Sirtuin
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
T60001
Synonym: 3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide
Target: Sirtuin
7-Chloro-4-(piperazin-1-yl)quinoline
Fr13587
Synonym:
Target:
JFD00244
T15610
Synonym:
Target: Others
Tenovin-D3
T26259
Synonym: TenovinD3
Target:
WAY-354574
T80813
Synonym:
Target: Sirtuin
SirReal1-O-propargyl
T18641
Synonym: PROTAC Sirt2-binding moiety 1
Target: Others
SIRT5 inhibitor 9
T78857
Synonym:
Target: Sirtuin
SIRT5 inhibitor 8
T78856
Synonym:
Target: Sirtuin
1 2
Cat No. Product Name Synonyms Targets
TN1071 Ophiopogonin D' Sirtuin , UGT
Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
T2879 Fisetin TNF , Sirtuin , PPAR
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.
T3888 Scopolin Murrayin,Scopoloside Sirtuin
Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for...
T13795 Nicotinamide riboside Sirtuin
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.
T5S1133 Ganoderic acid D Apoptosis , Sirtuin
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...
T6220 Nicotinamide riboside chloride Sirtuin , Endogenous Metabolite
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
T2750 Ginkgolide C BN-52022 MMP , Sirtuin , Endogenous Metabolite , AMPK
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
T3S0175 Gardenia yellow alpha-Crocin,Crocin I,Crocine Sirtuin
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.
T1558 Resveratrol trans-Resveratrol,SRT 501 Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T4S1173 Agrimol B Sirtuin , PPAR
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T2S0300 Dihydrocoumarin Chroman-2-one,Hydrocoumarin,melilotin,2-chromanone,3,4-dihydrocoumarin Sirtuin
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
T4S0800 Demethyleneberberine P450 , NOS , NF-κB , HIF , AMPK
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01869 SIRT1 Protein, Human, Recombinant (His) Human E. coli
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...
TMPY-05241 SIRT5 Protein, Human, Recombinant (Flag) Human E. coli
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul...
TMPY-06954 SIRT5 Protein, Human, Recombinant (His) Human E. coli
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul...
TMPY-02893 NT5C3A/NT5C3 Protein, Human, Recombinant Human E. coli
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot...
TargetMol