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Cat No. | Product Name | Synonyms | Targets |
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T12922 | Sirtuin modulator 1 | SRT3025 Hydrochloride | Sirtuin |
Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM. | |||
T9999 | Sirtuin modulator 2 | N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide | Others , Sirtuin |
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities. | |||
T79903 | Sirtuin-1 inhibitor 1 | Sirtuin | |
Sirtuin-1 Inhibitor 1 (Compound 8) is a compound that impedes Sirtuin-1, a protein implicated in obesity-induced diabetes and aging-associated diseases [1]. | |||
T6679 | SRT 2104 | SRT2104,sirtuin modulator,GSK2245840 | Sirtuin |
SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator. | |||
T72483 | Sirtuin modulator 4 | ||
Sirtuin Modulator 4, a sirtuin modulator, exhibits an inhibitory effect on SIRT1, presenting an EC 50 value ranging from 51-100 μM. It is potentially useful in research aimed at prolonging cell lifespan and preventing a ... | |||
T74672 | Sirtuin modulator 5 | ||
Sirtuin Modulator 5, a sirtuin modulating agent, activates SIRT1 with an efficacy marked by a DC50 value of less than 50 μM. It is applicable in enhancing cell longevity and is researched for its therapeutic potential in... | |||
T21679 | 4'-bromo-Resveratrol | Sirtuin | |
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3) | |||
T3447 | Thiomyristoyl | Sirtuin | |
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. | |||
T3953 | Salermide | Apoptosis , Sirtuin | |
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. | |||
T12919 | SIRT-IN-2 | Sirtuin | |
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively). | |||
T1887 | Inauhzin | INZ | Sirtuin |
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54... | |||
T6984 | SirReal2 | Sirtuin | |
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. | |||
T22026 | AGK7 | Others , Sirtuin | |
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively). | |||
T12918 | SIRT-IN-1 | Sirtuin | |
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively). | |||
T5618 | AK-1 | Sirtuin | |
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells. | |||
T5490 | AK-7 | Sirtuin | |
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM. | |||
T7679 | UBCS039 | Sirtuin , Autophagy | |
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM) | |||
T9648 | SIRT1-IN-1 | Antiviral , Sirtuin | |
SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is an inhibitor of cytomegalovirus (CMV) with antiviral activity. | |||
T4062 | CAY10602 | Sirtuin | |
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende... | |||
T16932 | SRT 2183 | Apoptosis , Sirtuin | |
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM). | |||
T39233 | SIRT7 inhibitor 97491 | Sirtuin | |
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway. | |||
T1919 | Tenovin-1 | Tenovin 1 | Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy |
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. | |||
T1818 | Tenovin-6 | Tenovin 6 | Dehydrogenase , Sirtuin , Autophagy |
Tenovin-6 is a p53 transcriptional activity agonist. | |||
T4019 | Cambinol | SIRT1/2 Inhibitor IV,NSC 112546 | Apoptosis , Phospholipase , Sirtuin |
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca... | |||
T8480 | Tenovin-6 Hydrochloride | Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy | |
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . | |||
T6671 | Sirtinol | Apoptosis , Sirtuin , Autophagy | |
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM). | |||
T9998 | MIND4-19 | Sirtuin | |
MIND4-19 is an inhibitor of SIRT2 with antitumor activity. | |||
T15263 | Selisistat R-enantiomer | EX-527 (R-enantiomer) | Sirtuin |
Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM). | |||
T4328 | OSS_128167 | SIRT6-IN-1 | HBV , Sirtuin |
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). | |||
T4108 | 3-TYP | 3-(1H-1,2,3-triazol-4-yl) pyridine | Sirtuin |
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor. | |||
T6111 | Selisistat | EX-527,SEN0014196 | Sirtuin |
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea. | |||
T6371 | AGK2 | Apoptosis , Sirtuin | |
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor. | |||
T5096 | SRT 1720 | Sirtuin , Autophagy | |
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3. | |||
T8346 | SRT 1460 | SRT1460 | Sirtuin |
SRT 1460 is a SIRT1 activator. | |||
T7058 | Selisistat S-enantiomer | EX-527 S-enantiomer,EX-527 (S-enantiomer) | Sirtuin |
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3. | |||
T9320 | YK-3-237 | B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid | Sirtuin |
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca... | |||
T22595 | B2 | Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline | Others , Sirtuin |
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease | |||
T2160 | Suramin Sodium Salt | BAY-205,Suramin hexasodium salt,NF-060 | Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite |
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f... | |||
T12921 | SIRT5 inhibitor 1 | Sirtuin | |
SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases. | |||
T12920 | Sirt2-IN-1 | Sirtuin | |
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM). | |||
T77653 | Z26395438 | Sirtuin | |
Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM. | |||
T60064 | WAY-270360 | N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide | EGFR , Sirtuin |
WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor. | |||
T60001 | Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) | 3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide | Sirtuin |
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or pre... | |||
Fr13587 | 7-Chloro-4-(piperazin-1-yl)quinoline | ||
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles. 7-Chloro-4-(piperazin-1-yl)q... | |||
T15610 | JFD00244 | Others | |
JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect. | |||
T26259 | Tenovin-D3 | TenovinD3 | |
Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner. | |||
T80813 | WAY-354574 | Sirtuin | |
WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1]. | |||
T18641 | SirReal1-O-propargyl | PROTAC Sirt2-binding moiety 1 | Others |
SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates by binding to the cereblon ligand through a linker, facilita... | |||
T78857 | SIRT5 inhibitor 9 | Sirtuin | |
SIRT5 inhibitor 9 (compound 14), with an IC50 of 4.07 μM, is a competitive inhibitor of the sirtuin SIRT5, exhibiting potential anticancer properties [1]. | |||
T78856 | SIRT5 inhibitor 8 | Sirtuin | |
SIRT5 inhibitor 8 (compound 10) serves as a competitive inhibitor of sirtuin SIRT5, exhibiting an IC50 of 5.38 μM, and possesses anticancer potential [1]. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1071 | Ophiopogonin D' | Sirtuin , UGT | |
Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10. | |||
T2879 | Fisetin | TNF , Sirtuin , PPAR | |
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects. | |||
T3888 | Scopolin | Murrayin,Scopoloside | Sirtuin |
Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for... | |||
T13795 | Nicotinamide riboside | Sirtuin | |
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. | |||
T5S1133 | Ganoderic acid D | Apoptosis , Sirtuin | |
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr... | |||
T6220 | Nicotinamide riboside chloride | Sirtuin , Endogenous Metabolite | |
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. | |||
T2750 | Ginkgolide C | BN-52022 | MMP , Sirtuin , Endogenous Metabolite , AMPK |
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body. | |||
T3S0175 | Gardenia yellow | alpha-Crocin,Crocin I,Crocine | Sirtuin |
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects. | |||
T1558 | Resveratrol | trans-Resveratrol,SRT 501 | Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal |
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop... | |||
T4S1173 | Agrimol B | Sirtuin , PPAR | |
1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb. | |||
T2S0300 | Dihydrocoumarin | Chroman-2-one,Hydrocoumarin,melilotin,2-chromanone,3,4-dihydrocoumarin | Sirtuin |
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively. | |||
T4S0800 | Demethyleneberberine | P450 , NOS , NF-κB , HIF , AMPK | |
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01869 | SIRT1 Protein, Human, Recombinant (His) | Human | E. coli |
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote... | |||
TMPY-05241 | SIRT5 Protein, Human, Recombinant (Flag) | Human | E. coli |
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul... | |||
TMPY-06954 | SIRT5 Protein, Human, Recombinant (His) | Human | E. coli |
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul... | |||
TMPY-02893 | NT5C3A/NT5C3 Protein, Human, Recombinant | Human | E. coli |
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot... |