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Search Result

Search Results for "sirtuin"

Targets

Sirtuin

Compounds

Cat No. Product Name
T12922 Sirtuin modulator 1 SRT3025 Hydrochloride Sirtuin
Sirtuin modulator 1 是 SIRT1 的调节剂，EC1.5 < 1 μM。
T72483 Sirtuin modulator 4
Sirtuinmodulator 4 是 sirtuin 调节剂。Sirtuinmodulator 4 对 SIRTl 具有抑制效应，EC50值为 51-100 μM。Sirtuinmodulator 4 可用于延长细胞寿命以及预防各种疾病...
T74672 Sirtuin modulator 5
Sirtuinmodulator 5 是一种sirtuin 调节剂。Sirtuinmodulator 5 可以激活SIRTl，DC50值 <50 μM。Sirtuinmodulator 5 可用于增加细胞的寿命并用于研究多种疾病，包括例如...
T6679 SRT 2104 GSK2245840,SRT2104,sirtuin modulator Sirtuin
SRT2104 是一种高度选择性、可通过血脑屏障的 Sirt1激活剂，依赖于 NAD+，增加 Sirt1 蛋白水平，用于糖尿病和亨廷顿氏症的研究。
T21679 4'-bromo-Resveratrol Sirtuin
4'-Bromo-resveratrol 是Sirtuin-1和Sirtuin-3的双重抑制剂。它通过线粒体代谢重编程，使黑色素瘤细胞的生长受到抑制。它通过代谢重编程、影响细胞周期以及细胞凋亡的信号传导，使其在黑色素瘤细胞中发挥抗增殖作用。
T16932 SRT 2183 Apoptosis , Sirtuin
SRT 2183 是一种选择性Sirtuin-1激活剂，其EC1.5值为 0.36 μM。它诱导生长停滞和凋亡，同时伴随 STAT3 和 NF-κB 去乙酰化，并降低 c-Myc 蛋白水平。
T5618 AK-1 Sirtuin
AK-1是一种特异性有效和细胞可渗透的SIRT2抑制剂，其IC50值为 12.5 μM。它可防止阿尔茨海默病模型中的海马神经退行性变并诱导结肠癌细胞中的细胞周期停滞。
T3447 Thiomyristoyl Sirtuin
Thiomyristoyl 是一种高效特异性SIRT2抑制剂，IC50值为28 nM。
T22026 AGK7 Others , Sirtuin
AGK7 是 sirtuin 2 (SIRT2) 抑制剂。它在体外和帕金森病果蝇模型中均能抑制多巴胺能细胞的凋亡。在帕金森病细胞模型中，它改善了 α-突触核蛋白毒性和修饰的包涵体形态
T3953 Salermide Apoptosis , Sirtuin
Salermide 是一种 Sirt1 和 Sirt2 的抑制剂，可诱导强烈的癌症特异性细胞凋亡。
T6671 Sirtinol 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 Sirtuin , Apoptosis , Autophagy
Sirtinol 是一种 sirtuin 的抑制剂，对 ySir2，hSIRT2 和 hSIRT2 的IC50值分别为 48 μM，57.7 μM 和 131 μM。
TN1071 Ophiopogonin D' Sirtuin , UGT
Ophiopogonin D'可以以剂量依赖性方式激活 SIRT1。 Ophiopogonin D'也非竞争性地抑制 UGT1A6 和 UGT1A10。
T12919 SIRT-IN-2 Sirtuin
SIRT-IN-2 是一种 SIRT1/2/3 有效抑制剂，IC50 分别为 4、1和 7 μM。
T1887 Inauhzin INZ Sirtuin
Inauhzin 是一种新型小分子，通过抑制 SIRT1 活性有效地重新激活 p53，促进人 Y 细胞的 p53 依赖性凋亡，在 A549 细胞中的IC50为3 uM。
T5490 AK-7 Sirtuin
AK-7 是一种大脑可渗透的 SIRT2 抑制剂，可在神经元模型中表征其降低胆固醇的特性，IC50 为 15.5 μM。
T12918 SIRT-IN-1 Sirtuin
SIRT-IN-1 是一种有效SIRT1/2/3抑制剂，IC50分别为 15，10，33 μM。
T12921 SIRT5 inhibitor 1 Sirtuin
SIRT5 inhibitor 1是一种高效且具有选择性的人类 Sirtuin 5脱酰基酶抑制剂（IC50：0.11μM）。SIRT5 inhibitor 1与衰老相关疾病有关。
T7679 UBCS039 Sirtuin , Autophagy
UBCS039 是一种合成的 SIRT6特异性激活剂，可在人癌细胞中诱导自噬，其 EC50值为38 μM。
T4062 CAY10602 Sirtuin
CAY10602 是一种SIRT1激活剂，可剂量依赖性地抑制 THP-1 细胞中脂多糖对 TNF-α 的 NF-κB 依赖性诱导。
T6984 SirReal2 Sirtuin
SirReal2 是一种同型选择性 Sirt2有效抑制剂，IC50值为 140 nM。它导致 HeLa 细胞中的微管蛋白高乙酰化并诱导检查点蛋白 BubR1 的不稳定。
Sirtuin modulator 1
T12922
synonym: SRT3025 Hydrochloride
Target:
Sirtuin modulator 4
T72483
synonym:
Target:
Sirtuin modulator 5
T74672
synonym:
Target:
SRT 2104
T6679
synonym: GSK2245840,SRT2104,sirtuin modulator
Target:
4'-bromo-Resveratrol
T21679
synonym:
Target:
SRT 2183
T16932
synonym:
Target:
AK-1
T5618
synonym:
Target:
Thiomyristoyl
T3447
synonym:
Target:
AGK7
T22026
synonym:
Target:
Salermide
T3953
synonym:
Target:
Sirtinol
T6671
synonym: 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
Target:
Ophiopogonin D'
TN1071
synonym:
Target:
SIRT-IN-2
T12919
synonym:
Target:
Inauhzin
T1887
synonym: INZ
Target:
AK-7
T5490
synonym:
Target:
SIRT-IN-1
T12918
synonym:
Target:
SIRT5 inhibitor 1
T12921
synonym:
Target:
UBCS039
T7679
synonym:
Target:
CAY10602
T4062
synonym:
Target:
SirReal2
T6984
synonym:
Target:
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