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Cat No. | Product Name | Synonyms | Targets |
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T10977 | DCEBIO | Potassium Channel | |
DCEBIO stimulates the secretion of Cl- through the activation of the hIK1 K + channel and the activation of the apical Cl- conductance. DCEBIO is a derivative of 1-EBIO and a very strong activator of Cl- secretion by T84... | |||
T20968 | CyPPA | Potassium Channel , Dopamine Receptor | |
CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization. | |||
T13164 | Tipepidine hydrochloride | Potassium Channel , Dopamine Receptor | |
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect. | |||
T2604 | 1-EBIO | Calcium Channel | |
1-EBIO (1-EBIO) is a calium channel agonist. | |||
T14982 | Clofilium tosylate | Potassium Channel | |
Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. | |||
T4224 | ML335 | Potassium Channel | |
ML335 is a selective activator of TREK-1 and TREK-2. | |||
T15385 | Glibornuride | Potassium Channel | |
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent. | |||
T7653 | JNJ 303 | Potassium Channel | |
JNJ 303 is a potent blocker of IKs (IC50 : 64 nM). | |||
T10566 | BMS-191095 | Potassium Channel | |
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator. | |||
T3959 | ICA-069673 | ICA069673 | Potassium Channel |
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM). | |||
T3192 | NS1643 | Potassium Channel , HER , Autophagy | |
NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM. | |||
T16110 | ML418 | Potassium Channel | |
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1. | |||
T22745 | DPO-1 | Potassium Channel | |
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels | |||
T7612 | ICA 110381 | Potassium Channel | |
ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy | |||
T12255 | NS19504 | Potassium Channel | |
NS19504 is an activator of Ca2+-activated K+ channel with EC50 of 11.0 µM. NS19504 shows relaxing effect on bladder smooth muscle spontaneous phasic contractions[1]. | |||
T5444 | CLP290 | CLP-290 | Potassium Channel |
CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications. | |||
T60061 | RU-TRAAK-2 | Potassium Channel | |
RU-TRAAK-2 is a reversible inhibitor of TWIK-related arachidonic acid-stimulated K+ channel with no activity for non-K2P channels including Kv1.2, GIRK2, and Slo1. | |||
T6245 | BAPTA-AM | BAPTA/AM | Potassium Channel |
BAPTA-AM is a calcium chelator that is cell-permeable and selective, blocking hERG, hKv1.3, and hKv1.5 channels (IC50=1.3/1.45/1.23 μM). BAPTA-AM has a 105-fold higher affinity for Ca2+ than for Mg2+, and can be used for... | |||
T10979 | DCPIB | Potassium Channel , Chloride channel | |
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1... | |||
T4294 | NS 11021 | NS11021 | Potassium Channel |
NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels | |||
T9778 | KCNQ1 activator-1 | Potassium Channel | |
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- is a potent KCNQ1 channel activator that can be used in long QT syndrome (LQTS) studies. | |||
T16420 | P-1075 | Potassium Channel | |
P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c... | |||
T7899 | VU0810464 | Potassium Channel | |
VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. | |||
T7538 | Tetraethylammonium chloride | Potassium Channel | |
Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties. | |||
T2712 | Nifekalant hydrochloride | Potassium Channel | |
Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM. It is a Class III antiarrhythmic compound and can be used in the study of tachyarrhythmias. | |||
T15545 | ICA-27243 | Potassium Channel | |
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. | |||
T27624 | Iptakalim Hydrochloride | Potassium Channel , AChR | |
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... | |||
T0451 | Minoxidil | U10858 | Potassium Channel , COX |
Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects. | |||
T13320L | VU591 | Potassium Channel | |
1222810-74-3 | |||
T0979 | Dequalinium chloride | Dequafungan,Danical,Decabis | Potassium Channel , PKC |
Dequalinium chloride (Decabis) , a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ... | |||
T6186 | TRAM-34 | Triarylmethane-34,TRAM 34 | Potassium Channel , IκB/IKK |
TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450. The selective activity of TRAM-34(TRA... | |||
T3528 | Senicapoc | ICA-17043 | Potassium Channel |
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 =... | |||
T3102 | NS-1619 | Apoptosis , Potassium Channel | |
NS1619 have cardio-protective effects after ischemia-reperfusion injury. | |||
T9070 | ASP2905 | ASP-2905 | Potassium Channel |
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities | |||
T1054 | Tolbutamide | HLS 831 | Potassium Channel , Autophagy |
Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. | |||
T11529 | H3B-120 | Others , Potassium Channel | |
H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity. | |||
T4030 | ML213 | CID-3111211 | Potassium Channel |
ML213 (CID-3111211) is a selective activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. | |||
T8391 | Cesium chloride | CsCl | Potassium Channel |
Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth. | |||
T1752 | NS6180 | Potassium Channel | |
NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation. | |||
T16347 | NS3623 | Potassium Channel | |
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e... | |||
T26324 | VU0071063 | VU 0071063,VU-0071063 | Potassium Channel |
VU0071063 is a Kir6.2/SUR1 activator. | |||
TQ0179 | PAP-1 | 5-(4-Phenoxybutoxy)psoralen | Potassium Channel |
PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM). | |||
T15286 | Flindokalner | BMS-204352 | Potassium Channel |
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p... | |||
T8581 | Flecainide hydrochloride | Others | |
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. | |||
T16348 | NS5806 | NS-5806 | Potassium Channel |
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). | |||
T14984 | CLP257 | Potassium Channel | |
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al... | |||
T17262 | XE 991 dihydrochloride | Others , Potassium Channel | |
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, r... | |||
T12478 | Pinacidil monohydrate | Potassium Channel | |
Pinacidil monohydrate is a potassium channel activator, antihypertensive drug. | |||
T3557 | GAL-021 | GAL 021 | Potassium Channel |
GAL-021 an intravenous BKCa-channel blocker. | |||
T11966 | MCHR1 antagonist 2 | HER , Melanin-concentrating Hormone Receptor (MCHR) | |
MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG. |
Cat No. | Product Name | Synonyms | Targets |
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TN1092 | O-Nornuciferine | Potassium Channel , HER | |
O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM. | |||
T8189 | Dihydroberberine | Potassium Channel , HSP , HER | |
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interacti... | |||
T0690 | Quinine | Potassium Channel , Platelet aggregation , Parasite | |
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances... | |||
T0801 | Tannic acid | Gallotannic acid | Potassium Channel , HER , CXCR |
Tannic acid (Gallotannic acid) is a novel hERG channel blocker. | |||
T3S1873 | Talatisamine | Potassium Channel | |
1. Talatisamine (12 μM) and TEA (5mM) inhibits the enhanced I(K) caused by Aβ4 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. 2. Talat... | |||
T3054 | Daurisoline | (R,R)-Daurisoline | Others , Potassium Channel , Autophagy |
Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker. | |||
T1186 | Ifenprodil Tartrate | Potassium Channel , NMDAR , iGluR | |
Ifenprodil is a selective NMDA receptor (glutamate) antagonist. | |||
T3A2467 | Allocryptopine | Thalictrimine,Fagarine I | Potassium Channel |
Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively. | |||
T7938 | Quinidine | Parasite | |
Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria. | |||
T4333 | Quinine dihydrochloride | Quinine bimuriate | Others |
Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). | |||
TMS2171 | (±)-Naringenin | Salipurpol,Naringenine,Naringenin | Potassium Channel |
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes. | |||
T8182 | Guanfu base A | Guan-fu base A | P450 , Potassium Channel , HER |
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current. | |||
T3S0081 | Oxypeucedanin | (+-)-Oxypeucedanin,Oxypeucadanin | Potassium Channel |
1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke... | |||
T37709 | 2,2,2-Trichloroethanol | Potassium Channel , Endogenous Metabolite | |
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1]. 2,2,2-trichloroethanol activates a nonclassical ... | |||
T3876 | Loureirin B | PAI-1 , ERK , Potassium Channel , JNK | |
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw... | |||
T3S0870 | Paederosidic acid methyl ester | ATPase , Potassium Channel , NO Synthase | |
Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels. | |||
T3092 | Nigericin sodium salt | Potassium Channel , NOD-like Receptor (NLR) , Antibacterial , Antibiotic , NOD | |
Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-... | |||
T0266 | Quinidine hydrochloride monohydrate | Quinidine hydrochloride | Potassium Channel , Sodium Channel , Parasite |
Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid... | |||
T7210 | Guanosine 5'-diphosphate | GDP | Endogenous Metabolite |
Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. | |||
T6631 | Quinine hydrochloride dihydrate | Quinine HCl Dihydrate | Potassium Channel , Parasite |
Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria. | |||
T2996 | Tetrandrine | NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A | Potassium Channel , Calcium Channel |
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c... | |||
T8040 | Cholesterol myristate | Cholesteryl myristate,Cholesteryl tetradecanoate | Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR |
Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i... | |||
T8125 | Quinidine sulfate dihydrate | Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate | P450 |
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor | |||
T3402 | 20(S)-Ginsenoside Rg3 | 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 | EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite |
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c... |
Cat No. | Product Name | Species | Expression System |
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TMPH-03603 | KcsA Protein, S. coelicolor, Recombinant (His) | Streptomyces coelicolor | in vitro E. coli expression system |
KcsA Protein, S. coelicolor, Recombinant (His) is expressed in in vitro E. coli expression system. |