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Results for "

Glioma

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    85
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitory_Antibodies
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ng 52
NG-52, NG52, Compound 52
T2028212779-48-1
NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.
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U-83836E
T23480137018-55-4In house
U-83836E (lazaroid ) has neuroprotective activity and anti-tumor activity, inhibits glioma cell proliferation, inhibits tumor necrosis factor and reverses endotoxin-induced shock.
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6-8 weeks
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Vacquinol-1
Vacquinol 1
T70085428-80-8In house
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
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smba1
T8792906440-37-7In house
SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.
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6-8 weeks
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Phenoxybenzamine hydrochloride
NCI-c01661, NSC 37448, Phenoxybenzamine HCl
T115863-92-3
Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
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Hematoporphyrin dihydrochloride
Hematoporphyrin IX dihydrochloride
T321317696-69-4
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) is a substrate for affinity chromatography of heme-binding proteins.
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(±)-α-Bisabolol
Bisabolol
T8199515-69-5
(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating, anti-inflammatory, antioxidant and anticancer activities. (±)-α-Bisabolol has anticancer effects on A549 NSC-LC cells by inducing cell cycle arrest, mitochondrial death and inhibiting PI3K Akt signaling (IC50 = 15 μM). (±)-α-Bisabolol can induce apoptosis of glioma cells.
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7-10 days
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DL-Tryptophan
(±)-Tryptophan, Tryptophan
TN228554-12-6
DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.
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NIK-250
NIK250
T281731000817-20-8In house
NIK-250 is a P-glycoprotein inhibitor. NIK250 could reverse multidrug resistance in human glioma cells.
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8-10 weeks
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Imipramine
HSDB 3100, Melipramine, HSDB3100, Dimipressin, HSDB-3100
T2002550-49-7
Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.
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6-8 weeks
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Germacrone
T29456902-91-6
Germacrone is extracted from Curcuma zedoaria and has anti-inflammatory, anti-androgenic and antiviral activities. It also inhibits the proliferation of glioma cells by promoting apoptosis.
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Eflornithine
α-difluoromethylornithine, RMI71782, MDL71782, DFMO
T4081170052-12-9
Eflornithine (DFMO) is a selective and orally available ornithine decarboxylase inhibitor that delays hair overgrowth.Eflornithine is used in the study of African trypanosomiasis, malignant glioma, and sleeping sickness.
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Glycitein
Glycetein
T6S032540957-83-3
1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.
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Tricin
TN1068520-32-1
Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7.
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ON123300
T69201357470-29-1
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4 Ark5 PDGFRβ FGFR1 RET Fyn (IC50: 3.9 5 26 26 9.2 11 nM).
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TargetMol | Inhibitor Sale
Antineoplaston A10
NSC-648539
T713191531-30-5
Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
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G5-7
JAK2 inhibitor G5-7
T8742939681-36-4
JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for glioma study
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Cycloartenol
Handianol, Cycloarterenol
T10910469-38-5
Cycloartenol (Handianol) is a plant sterol compound found widely in plants with anti-inflammatory, anti-tumor, antioxidant, and antibacterial properties. It inhibits glioma cell migration and p38 MAPK phosphorylation, and is used in plant growth and development studies.
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ADDA 5 hydrochloride
T14126473268-46-1
ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50 values of 18.93 μM for purified CcO from human glioma and 31.82 μM for CcO from bovine heart.
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7-10 days
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AMG 511
T142141253573-53-3
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks (Kis of 4 nM, 6 nM, 2 nM, and 1 nM for PI3Kα, β, δ, and γ, respectively), exhibiting anti-tumor activity in a mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling as indicated by a decrease in p-Akt (Ser473).
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Lactacystin
T15702133343-34-7
Lactacystin is a natural non-peptide proteasome inhibitor and highly specific anticancer drug that controls the UPS of cellular protein turnover and inhibits alkaline cell proliferation, and is able to be used as a model for studying dementia, induces neurite outgrowth and transiently elevated levels of cAMP, inhibits angiogenesis, triggers apoptosis in glioma cells, and can penetrate the blood-brain barrier (BBB).
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trans-AUCB
t-AUCB
T17158885012-33-9
trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor, with IC50 values of 1.3 nM for hsEH, 8 nM for mouse sEH, and 8 nM for rat sEH.
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USL311
T172081373268-67-7
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing tumor cells, with anti-tumor activ
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LDN-214117
T19441627503-67-6
LDN-214117 is a potent and selective ALK2 inhibitor.
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