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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7317 | CU-CPT-9a | TLR | |
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells- | |||
T7347 | CU-CPT-8m | TLR8-specific antagonist | TLR |
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM) | |||
T27076 | 8-Cyclopentyl-1,3-dimethylxanthine | CPT | Adenosine Receptor |
8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a potent antagonist of adenosine A1 receptor. | |||
T3S1957 | 9-amino-CPT | Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin | Topoisomerase |
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. | |||
T22698 | TLR3-IN-1 | CU CPT 4a | TLR |
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell... | |||
T6228 | Irinotecan | CPT-11,Topotecin,(+)-Irinotecan | Topoisomerase , Autophagy |
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting... | |||
T41018 | CPT-157633 | ||
CPT-157633 is a difluoro-phosphonomethyl phenylalanine derivative that acts as a potent inhibitor of the enzyme PTP1B. It effectively prevents the development of glucose intolerance induced by binge drinking. | |||
T24610 | Pegamotecan | Prothecan,PEG-camptothecin,PEG-beta-CPT | Topoisomerase |
Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung and pancreatic cancers. | |||
T0486L | Irinotecan Hydrochloride | Camptothecin 11 hydrochloride,CPT-11 hydrochloride | Topoisomerase , Autophagy |
Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptoth... | |||
T38696 | Rp-8-CPT-cAMPS | ||
Rp-8-CPT-cAMPS is a powerful and competitive antagonist of cAMP-induced activation of cAMP-dependent protein kinase (PKA) I and II. Acting as a potent cAMP analog, Rp-8-CPT-cAMPS exhibits a preference for site A of RI ov... | |||
T38694 | Sp-8-CPT-cAMPS | ||
Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, ... | |||
T7302 | CU-CPT9b | CU-CPT-9b,TLR8-specific antagonist 1 | TLR |
CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 valu... | |||
T0486 | Irinotecan hydrochloride trihydrate | Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate | Topoisomerase , Autophagy |
Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1. | |||
T1123 | Camptothecin | NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT | Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal |
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis. | |||
T36678 | Rp-8-CPT-cAMPS sodium | ||
Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, ... | |||
T22014 | 8-CPT-2Me-cAMP, sodium salt | ||
8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for act... | |||
T21705 | 8-CPT-Cyclic AMP (sodium salt) | ||
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium functions dually as a selective activator of cyclic AMP-dependent protein kinase (PKA) and as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA), demonstrating a... | |||
T73422 | CPT-Se4 | Topoisomerase | |
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance and total thiol content while increasing ROS concentrations... | |||
T73421 | CPT-Se3 | Topoisomerase | |
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. This compound diminishes the GSH/GSSG ratio and total thiols w... | |||
T10899 | CU-CPT17e | TLR | |
CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9). |