abeta — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3259	FPS-ZM1		Beta Amyloid , advanced glycation end products
	FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.		Beta Amyloid , advanced glycation end products
T7527	Frentizole		Beta Amyloid
	Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction		Beta Amyloid
T22694	CRANAD 2		Others
	CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-f...		Others
T5447	Anle138b		Beta Amyloid , Others
	Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease		Beta Amyloid , Others
T7905	PBD-150		Beta Amyloid
	PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)		Beta Amyloid
TP1856	Colivelin		Beta Amyloid , STAT
	Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).		Beta Amyloid , STAT
T12532	PQM130		Beta Amyloid
	PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.		Beta Amyloid
TN6919	Methyl tridecanoate		Beta Amyloid , AChE
	Methyl tridecanoate is a natural product.		Beta Amyloid , AChE
T7490	ARN2966		Beta Amyloid
	ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.		Beta Amyloid
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T21825	TAE-1		Beta Amyloid , AChE
	TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.		Beta Amyloid , AChE
T2212	Geniposide		Beta Amyloid , Influenza Virus
	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation...		Beta Amyloid , Influenza Virus
T3914	Saikosaponin C		Beta Amyloid , Caspase
	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.		Beta Amyloid , Caspase
T21890	JLK6		Gamma-secretase
	JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling		Gamma-secretase
T8012	Scyllo-Inositol	Scyllitol	Beta Amyloid , Endogenous Metabolite
	Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease.		Beta Amyloid , Endogenous Metabolite
T14199	ALZ-801	Valiltramiprosate	Beta Amyloid
	ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. ALZ-801 is an advanced and markedly improved candidate for the treatment of Alzheimer's disease. ALZ-801 is a potent and orally available small-m...		Beta Amyloid
T4398	LX2343		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
T11043	Dihydroergocristine mesylate	DHEC (mesylate)	Beta Amyloid
	Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebro...		Beta Amyloid
T6125	Semagacestat	LY450139	Beta Amyloid , Gamma-secretase
	Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).		Beta Amyloid , Gamma-secretase
T6202	DAPT	LY-374973,GSI-IX	Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
	DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.		Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy