azd — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T30249	AZD 7009	AZD-7009,AZD7009	Sodium Channel
	AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, an...		Sodium Channel
T30251	AZD-1305	UNII-CZO834LXQM,AZD 1305	Others
	AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in st...		Others
T26712	AZD-1656	AZD 1656	Glucokinase
	AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes.		Glucokinase
T30260	AZD-5672	AZD 5672,AZD5672,UNII-61XQN688TW	HER , P-gp , CCR
	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheu...		HER , P-gp , CCR
T30248	AZD 3043	TD 4756,THRX 918661,AZD-3043,AZD3043	GABA Receptor
	AZD 3043 (THRX 918661) is a variant modulator of the γ-aminobutyric acid type A receptor, a novel sedative-hypnotic and a potential short-acting anesthetic that produces hypnosis and EEG suppression in rats.AZD 3043 pote...		GABA Receptor
T14389	AZD 9272		GluR
	AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.		GluR
T36200	AZD 3147		mTOR
	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.		mTOR
T14388	AZD 4017		Dehydrogenase
	AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).		Dehydrogenase
T9682	AZD-4877	AZD4877	Apoptosis , Kinesin
	AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and med...		Apoptosis , Kinesin
T7681	AZD-5069		CXCR
	AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).		CXCR
T30258	AZD-4818	CCR1 antagonist	CCR
	AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.		CCR
T9756	AZD-9574		PARP
	AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.		PARP
T14369	AZD-0284		ROR
	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].		ROR
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T6774	AZD-8835	AZD8835	PI3K
	AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).		PI3K
T2506	AZD-5438	AZD5438	CDK
	AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).		CDK
T2484	AZD-2461		PARP
	AZD2461 is a novel PARP inhibitor.		PARP
T1859	AZD-8055		Apoptosis , mTOR , Autophagy
	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.		Apoptosis , mTOR , Autophagy
T3069	AZD-1480		JAK
	AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...		JAK
T6093	AZD-7762	AZD7762	Chk
	AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.		Chk