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BTK

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.
Cat. No. Product name CAS No. Purity Chemical Structure
TQ0039 (±)-Zanubrutinib 1633350-06-7 98%
(±)-Zanubrutinib is a specific, potent and orally available Btk inhibitor.
T10240 ACP-5862 2230757-47-6 98%
ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK). Acalabrutinib is an irreversible and highly selective ...
T12673L PF-06250112 1609465-89-5 98%
PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM. PF-06250112 displays an inhibitory effect toward BMX nonreceptor tyrosine kinase an...
T12152 N-piperidine Ibrutinib hydrochloride 2231747-18-3 98%
N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).
T14357 Spebrutinib besylate 1360053-81-1 98%
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).
T14956 CHMFL-BTK-01 2095280-64-9 98%
CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.
T16853 SB-633825 956613-01-7 98%
SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 1...
T11379 GDC-0834 1133432-49-1 98%
GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and r...
T9814 JAK3/BTK-IN-1 2674036-91-8 98%
JAK3/BTK-IN-1 is a potent inhibitor of JAK3 / BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signal...
T35330 BTK inhibitor 1 (Compound 27) 2230724-66-8 98%
BTK inhibitor 1 (compound 27) is an inhibitor ofBTKwith an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.
T15365 G-744 1346669-54-2 98%
G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthriti...
T16441 PCI-33380 1022899-36-0 98%
PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.
T16265 Naluzotan 740873-06-7 98%
Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM. Naluzotan is used for the treatment of anxiety...
TQ0236 Tirabrutinib 1351636-18-4 98%
Tirabrutinib (ONO-4059) is a highly specific and orally bioavailable BTK inhibitor (IC50: 2.2 nM).
T13564 AZ7550 1421373-99-0 98%
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T9705 TL-895 1415823-49-2 98%
TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and...
T14692 BMX-IN-1 1431525-23-3 98%
BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM...
T9813 JAK3/BTK-IN-2 2674036-93-0 98%
JAK3/BTK-IN-2 is a potent inhibitor of JAK3 / BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signal...
T2603 Spebrutinib 1202757-89-8 97.14%
Spebrutinib is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.
T4268 CHMFL-BMX-078 1808288-51-8 98%
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
(±)-Zanubrutinib
TQ0039
(±)-Zanubrutinib is a specific, potent and orally available Btk inhibitor.
ACP-5862
T10240
ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK). Acalabrutinib is an irreversible and highly selective ...
PF-06250112
T12673L
PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM. PF-06250112 displays an inhibitory effect toward BMX nonreceptor tyrosine kinase an...
N-piperidine Ibrutinib hydrochloride
T12152
N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).
Spebrutinib besylate
T14357
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).
CHMFL-BTK-01
T14956
CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.
SB-633825
T16853
SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 1...
GDC-0834
T11379
GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and r...
JAK3/BTK-IN-1
T9814
JAK3/BTK-IN-1 is a potent inhibitor of JAK3 / BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signal...
BTK inhibitor 1 (Compound 27)
T35330
BTK inhibitor 1 (compound 27) is an inhibitor ofBTKwith an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.
G-744
T15365
G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthriti...
PCI-33380
T16441
PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.
Naluzotan
T16265
Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM. Naluzotan is used for the treatment of anxiety...
Tirabrutinib
TQ0236
Tirabrutinib (ONO-4059) is a highly specific and orally bioavailable BTK inhibitor (IC50: 2.2 nM).
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
TL-895
T9705
TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and...
BMX-IN-1
T14692
BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM...
JAK3/BTK-IN-2
T9813
JAK3/BTK-IN-2 is a potent inhibitor of JAK3 / BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signal...
Spebrutinib
T2603
Spebrutinib is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.
CHMFL-BMX-078
T4268
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
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