ocd

SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.

Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is similar to Imipramine in that selective inhibition of the serotonin uptake in the brain.

Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Golocdacimab (MEDI6570) is a fully human monoclonal antibody that specifically targets the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), with research indicating potential therapeutic applications for mitigating complications associated with type 2 diabetes mellitus and for the prophylaxis of hereditary angioedema (HAE) attacks.

Rocduntatug is an antibody targeting IGKC and can be used for oncology research.

Cefazolin sodium (cephazolin sodium) salt binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin sodium salt is the sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis.

Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.

Fmoc-D-Cha-OH (FDCO) is an apoptotic DNase γ inhibitor that inhibits the release of HMGB1.

Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

1-Boc-D-azetidine-2-carboxylic acid ,with CAS No. 228857-58-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Boc-D-azetidine-2-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-Boc-D,L-1-aminoindane-1-carboxylic acid ,with CAS No. 214139-26-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-Boc-D,L-1-aminoindane-1-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).

N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs), innovative therapeutic agents that combine the targeting ability of antibodies with potent cytotoxic drugs.

Boc-D-2,3-diaminopropionic acid (N-t-Boc-amino-D-alanine) is a derivative of an amino acid featuring a Boc protecting group. It is utilized in the synthesis of a powerful NMDA receptor glycine site agonist that exhibits specific activity towards the GluN2 subunit.

Fmoc-Dap(Boc)-OH, an amino acid derivative featuring an Fmoc protecting group, is utilized in the synthesis of bicyclic peptide tachykinin NK2 antagonists.

Octachlorodibenzo-p-dioxin (OCDD) is an environmental contaminant with no acute toxicity when administered. In rats, the systemic elimination half-life of Octachlorodibenzo-p-dioxin (50 μg/kg intravenously or 50-5000 μg/kg orally) is 3-5 months. It can accumulate and concentrate in the liver and adipose tissue after low-dose, repeated exposure. Repeated dosing of Octachlorodibenzo-p-dioxin leads to increased activity of 7-ethoxyresorufin-O-deethylase (7-EROD) and elevated total cytochrome P-450 levels.

(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).

Isochenodeoxycholic acid (isoCDCA), a bile acid and primary metabolite of ursodeoxycholic acid (UDCA), Isochenodeoxycholic acid exerts protective effects against ethanol-induced damage in HepG2 hepatocytes.

Boc-Dipiperidine-KLHDC2 ligand 1 is an E3 ubiquitin ligase ligand-linker conjugate, incorporating a KLHDC2 ligand. It is utilized in the synthesis of PROTAC BRD4 Degrader-31.

Fmoc-Dab(Boc)-OH is a chemical intermediate used for chemical synthesis.