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LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.

LY 517717 is an orally active inhibitor of coagulation factor Xa with antithrombotic activity for the study of venous thromboembolism (VTE).

LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.

LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.

Lilly 51641 is used as a MAO inhibitor.

LY 56110 is a novel nonsteroidal aromatase inhibitor.

LY 54761 is a bio-active chemical.

Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.

Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.

Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, which increases ERK1/2 activation, inhibits biofilm formation, and alters biofilm structure, and is used in the treatment of acute pain and chronic arthritis.

LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).

LY550410 is a small molecule that acts as an ATP-competitive type I TGF-β receptor kinase inhibitor (type ITGF-β receptorkinase) featuring a heteroaromatic ring, which can effectively bind to the active site of the kinase domain. This compound regulates the TGF-β signaling pathway, thereby influencing gene expression and ultimately promoting cell growth. LY550410 holds potential for use in cancer research.

Gly5-Ahx-DM1 is a transpeptidase reaction-type Drug-linker with an innovative highly stable and degradable linker. DM1 is a microtubulin inhibitor and can be used in the synthesis of antibody-drug conjugates (ADCs).

Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway. It can be used in acute lung injury/acute respiratory distress syndrome research.

Aranotin is a fungal toxin isolated from Arachniotus aureus with activity against RNA viruses such as poliovirus, coxsackie virus, and rhino- and parainfluenza viruses. Aranotin inhibits viral RNA synthesis by impeding the activity of RNA-dependent RNA polymerase.

LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.

LY503430 is a AMPA receptor potentiator with oral activity. LY503430 has both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP.

LY-510929, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of hyperlipidaemia, metabolic disorders and type 2 diabetes.

LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.

LY-53857 free base is a bioactive chemical.

Naveglitazar (LY 519818, LY 9818) is a peroxisome proliferator-activated receptor (PPAR) modulator, which has entered phase II clinical trials for the treatment of type 2 diabetes.

PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA-Gly5.

Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.

Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).