ba-1

Potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro.

Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor.

PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.

BA-1049 is a selective ROCK2 inhibitor.

PBA-1105, an autophagy-targeting chimeric molecule (AUTOTAC), facilitates the self-oligomerization of p62. Additionally, PBA-1105 enhances the autophagic flux of Ub-conjugated aggregates.

PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.

ESBA-105 represents a highly stable, humanized single-chain Fv (scFv) antibody fragment specifically engineered to target and neutralize human tumor necrosis factor-alpha (TNF-α) with exceptional binding affinity. It effectively facilitates the measurable blockade of TNF-mediated pro-inflammatory signaling and apoptosis across various preclinical experimental models to evaluate the optimization of tissue penetration and pharmacokinetic stability during strictly monitored laboratory observation periods and functional neutralization assays.

Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.

SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.

Aminoglutethimide (BA-16038), an aromatase inhibitor, is used in the therapy of advanced BREAST Y.

Mefruside is an orally effective diuretic that reduces tubular reabsorption of electrolytes and water, suitable for studying edema and hypertension. It inhibits urea synthesis in an in vitro rat liver perfusion model.

BA 1 TFA acts as a potent agonist for the bombesin (BB) family of receptors, exhibiting high affinity binding to Bombesin receptor subtype-3 (BRS3), gastrin-releasing peptide receptor (GRPR), and neuromedin B receptor (NMBR), with IC50 values of 6, 0.4, and 2.5 nM, respectively [1].

BA 1 acetate is a potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in v

Lotilaner is an anthelmintic agent and a non-competitive GABA_A receptor antagonist with an IC₅₀ value of 23.84 nM for Drosophila GABA receptors. Lotilaner selectively acts on the nervous system of invertebrates to exert its anthelmintic effect and exhibits no significant affinity for mammalian GABA_A receptors.

Phenglutarimid is an anticholinergic. It is used as an antiparkinsonian agent.

PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.

TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.

Thiambutosine exhibits inhibitory activity against Mycobacterium leprae and mushroom tyrosinase, making it suitable for infection studies.

NRL-1049 dihydrochloride (BA-1049) is an orally active and selective inhibitor of Rho-associated protein kinase 2 (ROCK2) with an IC50 value of 0.59 μM. It demonstrates a 44-fold selectivity for ROCK2 over ROCK1, which has an IC50 value of 26 μM. NRL-1049 dihydrochloride can protect the blood-brain barrier following acute injury.

Carba1 is a bifunctional carbazole derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances the biosynthesis of NAD. It binds to the colchicine site on tubulin, potentially boosting the antitumor effects of various chemotherapeutics such as Paclitaxel. Carba1 has neuroprotective properties and regulates cellular energy metabolism. It is applicable in research on cancer and chemotherapy-induced peripheral neuropathy (CIPN).

Silagaba132 is a silicon-containing GABA derivative which treats neuropathic pain without central nervous system related side effects.

Silagaba161 is a silicon-containing GABA derivative which treats neuropathic pain without central nervous system related side effects.

ISRIB-A15 (ISR-IN-2) is an potent inhibitor of the integrated stress response with an EC50 of 0.8 nM.

trans-isrib A17 (ISR-IN-1) is an potent inhibitor of the integrated stress response with EC50 of 0.6 nM.