hdac8 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T24133	HDAC8-IN-20a	HDAC8 IN 20a,HDAC8IN20a,HDAC8 inhibitor-20a,HDAC8 inhibitor 20a	HDAC
	HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.		HDAC
T7082	HDAC8-IN-1		HDAC
	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ...		HDAC
T78861	HDAC8-IN-5		HDAC
	HDAC8-IN-5 (Compound 6a), with an inhibitory concentration (IC50) of 28 nM, is a potent HDAC8 inhibitor suitable for cancer research [1].		HDAC
T79082	HDAC8-IN-4		HDAC
	HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].		HDAC
T61858	HDAC8-IN-3
	HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in le...
T61549	HDAC8-IN-2
	HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 μM and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. It effectively kills schistosome larvae and ...
T62171	HDAC8/BRPF1-IN-1
	HDAC8/BRPF1-IN-1 (Compound 23a) is a dual HDAC8 and BRPF1 inhibitor that acts on human HDAC8 (IC50: 443 nM) and human BRPF1 (Kd: 67 nM). HDAC8/BRPF1-IN-1 has low in vitro activity against HDAC1 and 6.
T13996	1-Naphthohydroxamic acid		HDAC
	1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d...		HDAC
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T6325	PCI-34051	PCI 34051	Apoptosis , HDAC
	PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).		Apoptosis , HDAC
T6421	BRD73954		HDAC
	BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.		HDAC
T4370	Resminostat hydrochloride	4SC-201 hydrochloride,RAS2410 hydrochloride	HDAC
	Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 (IC50: 877 nM).		HDAC
T6161	Tubastatin A Hydrochloride	TSA HCl,Tubastatin A HCl	Apoptosis , HDAC , Autophagy
	Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).		Apoptosis , HDAC , Autophagy
T14947	CHDI-390576		HDAC
	CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity ...		HDAC
T10883	CRA-026440	PCI-34051	HDAC
	CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7 and 20 nM, respectively. CRA-026440 has anti-tumor and anti-a...		HDAC
T77334	HDAC-IN-57		Apoptosis , HDAC
	HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with ...		Apoptosis , HDAC
T10883L	CRA-026440 hydrochloride	CRA-026440 hydrochloride（847460-34-8 Free base）	HDAC
	CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM...		HDAC
T1966	Tubastatin A	Tubastatin A BASE	Apoptosis , HDAC , Autophagy
	Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except HDAC8.		Apoptosis , HDAC , Autophagy
T0431	Abexinostat	CRA 24781,PCI24781,PCI-24781,PCI 24781,CRA 024781	HDAC
	PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.		HDAC
T4481	Tucidinostat	HBI-8000,Chidamide,CS 055	HDAC
	Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and sho...		HDAC