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Metabolism MAO

MAO

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. They are found bound to the outer membrane of mitochondria in most cell types of the body. MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate monoamine neurotransmitters. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with monoamine oxidase inhibitors (MAOIs) which block the action of MAOs.
Cat No. product name
T8907 Minaprine dihydrochloride Minaprine dihydrochloride is a reversible MAO-A inhibitor; It weakly inhibit acetylcholinesterase. Minaprine dihydrochloride is an antidepressant for treatment ...
T1711 Harmine Harmine is an alkaloid isolated from seeds of Peganum harmala.
T4093 Afobazole hydrochloride Fabomotizole HCl (CM346 HCl), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, wi...
T0369 Ethaverine hydrochloride Ethaverine hydrochloride is a homologue of papaverine.
T3596 TB5 TB5 is a potent, selective and reversible inhibitor of hMAO-B.
T6862 Isatin Isatin is an endogenous MAO inhibitor.
T1747 Torezolid Tedizolid is an Oxazolidinone Antibacterial. The mechanism of action of tedizolid is as a Breast Cancer Resistance Protein Inhibitor.
T1549 Raloxifene hydrochloride Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estroge...
T0966 Sennoside A Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
T0084 Moclobemide Moclobemide is a reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
T0751 Furazolidone Furazolidone, a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,
T0300 Pargyline Pargyline is a monoamine oxidase inhibitor with antihypertensive properties.
T2900 Paeonol Paeonol is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
T3095 Tyramine Tyramine is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can ser...
T1455 Nialamide Nialamide is an MAO inhibitor that is used as an antidepressive agent.
T3933 Jatrorrhizine Jatrorrhizine is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal act...
T5050 Selegiline hydrochloride Selegiline hydrochloride is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM). Monoamine oxidase (MAO) inhibitors have utili...
T1578 Pargyline hydrochloride Pargyline hydrochloride is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties.
T0821 Iproniazid Phosphate Iproniazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI).
T1613 Hydralazine hydrochloride Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...
T0235 Modaline sulfate Modaline was a 2-methyl-3-piperidinopyrazine derivative found to inhibit monoamine oxidase (MAO) and showed a curative effect for the anti-depressant. Similar to...
T0338 Minaprine Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T2765 Rosmarinic acid Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
T6651 Safinamide mesylate Safinamide Mesylate, a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A.
T1025 Tranylcypromine (2-PCPA) hydrochloride Tranylcypromine Hydrochloride, a monoamine oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It ...
T1117 Clorgyline hydrochloride Clorgyline hydrochloride, a white powder, is served as monoamine oxidase inhibitor.
T0391 Linezolid Linezolid, the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including me...
T6962 Rasagiline Mesylate Rasagiline Mesylate is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.
T2741 Glycyrrhizin Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T1119 Rasagiline Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
T7048 1,4-Naphthoquinone 1, 4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase...
T5053 Eprobemide Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A (MAO-A).
T8849 PF-9601N PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in seve...
T10079 MAO-IN-1 MAO-IN-1 is an inhibitor of monoamine oxidase B (MAO B; IC50: 20 nM).
T23453 Tetrindole mesylate Tetrindole mesylate is a MAO-A inhibitor.
T22605 Bifemelane hydrochloride Bifemelane hydrochloride is a MAO inhibitor
TN4137 Glicoricone Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M.
TN3918 Echitovenidine Echitovenidine shows monoamine oxidase inhibitor activity.
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN3300 8alpha-Tigloyloxyhirsutinolide 13-O-acetate 8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
TN3294 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TN3116 5-Hydroxy-1-methoxyxanthone 5-Hydroxy-1-methoxyxanthone, 1,5-dihydroxyxanthone and 6-deoxyjacareubin are all antifungal against Cladosporium cucumerinum, while they show differing degrees o...
TN3024 4'-Demethyleucomin
TN2790 2'-O-Methylperlatolic acid 2'-O-Methylperlatolic acid and confluentic acid are monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba.
TN2553 1-Methyl-2-undecylquinolin-4(1H)-one 1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodi...
T8589 Amiflamine Amiflamine is an inhibitor of reversible MAO-A.
T16770 Ro 41-1049 hydrochloride Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).
T10617 Brofaromine Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).
T5323 MD 69276 MD 69276 (Toloxatone) is a reversible monoamine oxidase A (MAOA) inhibitor.
T18918 Azure B Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombi...
T15023 CX-157 CX-157 is a reversible monoamine oxidase-A (MAO-A) inhibitor (EC50:19.3 ng/mL).
T15010 CR4056 CR4056 is a selective inhibitor of human recombinant MAO-A (IC50: 202.7 nM) and a ligand of the imidazoline-2 receptor (I2R) (IC50: 596 nM).
T10146 4-Hydroxyderricin 4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B inhibitor (IC50: 3.43 μM). It also mildly inhibits DBH...
TN1705 Glycyrrhisoflavone Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase.
TN1120 Osthenol Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promot...
TN1099 Dihydroevocarpine Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
T7942 Tranylcypromine (hemisulfate) Tranylcypromine is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1)  with a rapid onset of activity.
TMS1743 Salvigenin Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.
T5887 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone (7-​Hydroxy-​3,​4-​dihydro-​2(1H)​-​quinolinone) is a weak MAO-A inhibitor(with an IC50 of 183 μM) .
T5648 Purpurin Purpurin was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative ...
T5676 (Z)-SU4312 (Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
T5678 N-(2-Aminoethyl)-5-chlor-2-pyridincarbox N-(2-Aminoethyl)-5-chlor-2-pyridincarbox is a reversible and selective mao-b inhibitor(Ki:7.9nM).
T5470 LAZABEMIDE LAZABEMIDE(Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).
T0418 Allylthiourea Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.
Minaprine dihydrochloride
T8907CAS 25953-17-7
Minaprine dihydrochloride is a reversible MAO-A inhibitor; It weakly inhibit acetylcholinesterase. Minaprine dihydrochloride is an antidepressant for treatment ...
Harmine
T1711CAS 442-51-3
Harmine is an alkaloid isolated from seeds of Peganum harmala.
Afobazole hydrochloride
T4093CAS 173352-39-1
Fabomotizole HCl (CM346 HCl), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, wi...
Ethaverine hydrochloride
T0369CAS 985-13-7
Ethaverine hydrochloride is a homologue of papaverine.
TB5
T3596CAS 948841-07-4
TB5 is a potent, selective and reversible inhibitor of hMAO-B.
Isatin
T6862CAS 91-56-5
Isatin is an endogenous MAO inhibitor.
Torezolid
T1747CAS 856866-72-3
Tedizolid is an Oxazolidinone Antibacterial. The mechanism of action of tedizolid is as a Breast Cancer Resistance Protein Inhibitor.
Raloxifene hydrochloride
T1549CAS 82640-04-8
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estroge...
Sennoside A
T0966CAS 81-27-6
Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
Moclobemide
T0084CAS 71320-77-9
Moclobemide is a reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
Furazolidone
T0751CAS 67-45-8
Furazolidone, a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,
Pargyline
T0300CAS 555-57-7
Pargyline is a monoamine oxidase inhibitor with antihypertensive properties.
Paeonol
T2900CAS 552-41-0
Paeonol is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
Tyramine
T3095CAS 51-67-2
Tyramine is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can ser...
Nialamide
T1455CAS 51-12-7
Nialamide is an MAO inhibitor that is used as an antidepressive agent.
Jatrorrhizine
T3933CAS 3621-38-3
Jatrorrhizine is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal act...
Selegiline hydrochloride
T5050CAS 14611-52-0
Selegiline hydrochloride is a selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM). Monoamine oxidase (MAO) inhibitors have utili...
Pargyline hydrochloride
T1578CAS 306-07-0
Pargyline hydrochloride is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties.
Iproniazid Phosphate
T0821CAS 305-33-9
Iproniazid is a non-selective, irreversible monoamine oxidase inhibitor (MAOI).
Hydralazine hydrochloride
T1613CAS 304-20-1
Hydralazine Hydrochloride is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydra...
Modaline sulfate
T0235CAS 2856-75-9
Modaline was a 2-methyl-3-piperidinopyrazine derivative found to inhibit monoamine oxidase (MAO) and showed a curative effect for the anti-depressant. Similar to...
Minaprine
T0338CAS 25905-77-5
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
Rosmarinic acid
T2765CAS 20283-92-5
Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
Safinamide mesylate
T6651CAS 202825-46-5
Safinamide Mesylate, a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A.
Tranylcypromine (2-PCPA) hydrochloride
T1025CAS 1986-47-6
Tranylcypromine Hydrochloride, a monoamine oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It ...
Clorgyline hydrochloride
T1117CAS 17780-75-5
Clorgyline hydrochloride, a white powder, is served as monoamine oxidase inhibitor.
Linezolid
T0391CAS 165800-03-3
Linezolid, the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including me...
Rasagiline Mesylate
T6962CAS 161735-79-1
Rasagiline Mesylate is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.
Glycyrrhizin
T2741CAS 1405-86-3
Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
Rasagiline
T1119CAS 136236-51-6
Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
1,4-Naphthoquinone
T7048CAS 130-15-4
1, 4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase...
Eprobemide
T5053CAS 87940-60-1
Eprobemide is a non-competitive reversible inhibitor of monoamine oxidase A (MAO-A).
PF-9601N
T8849CAS 133845-63-3
PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in seve...
MAO-IN-1
T10079CAS 124991-40-8
MAO-IN-1 is an inhibitor of monoamine oxidase B (MAO B; IC50: 20 nM).
Tetrindole mesylate
T23453CAS 170964-68-8
Tetrindole mesylate is a MAO-A inhibitor.
Bifemelane hydrochloride
T22605CAS 62232-46-6
Bifemelane hydrochloride is a MAO inhibitor
Glicoricone
TN4137CAS 161099-37-2
Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M.
Echitovenidine
TN3918CAS 7222-35-7
Echitovenidine shows monoamine oxidase inhibitor activity.
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
8alpha-Tigloyloxyhirsutinolide 13-O-acetate
TN3300CAS 83182-58-5
8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
TN3294CAS 67667-71-4
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
5-Hydroxy-1-methoxyxanthone
TN3116CAS 27770-13-4
5-Hydroxy-1-methoxyxanthone, 1,5-dihydroxyxanthone and 6-deoxyjacareubin are all antifungal against Cladosporium cucumerinum, while they show differing degrees o...
4'-Demethyleucomin
TN3024CAS 34818-83-2
2'-O-Methylperlatolic acid
TN2790CAS 38968-07-9
2'-O-Methylperlatolic acid and confluentic acid are monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba.
1-Methyl-2-undecylquinolin-4(1H)-one
TN2553CAS 59443-02-6
1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodi...
Amiflamine
T8589CAS 77502-96-6
Amiflamine is an inhibitor of reversible MAO-A.
Ro 41-1049 hydrochloride
T16770CAS 127917-66-2
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).
Brofaromine
T10617CAS 63638-91-5
Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).
MD 69276
T5323CAS 29218-27-7
MD 69276 (Toloxatone) is a reversible monoamine oxidase A (MAOA) inhibitor.
Azure B
T18918CAS 531-55-5
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombi...
CX-157
T15023CAS 205187-53-7
CX-157 is a reversible monoamine oxidase-A (MAO-A) inhibitor (EC50:19.3 ng/mL).
CR4056
T15010CAS 1004997-71-0
CR4056 is a selective inhibitor of human recombinant MAO-A (IC50: 202.7 nM) and a ligand of the imidazoline-2 receptor (I2R) (IC50: 596 nM).
4-Hydroxyderricin
T10146CAS 55912-03-3
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B inhibitor (IC50: 3.43 μM). It also mildly inhibits DBH...
Glycyrrhisoflavone
TN1705CAS 116709-70-7
Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase.
Osthenol
TN1120CAS 484-14-0
Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promot...
Dihydroevocarpine
TN1099CAS 15266-35-0
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
Tranylcypromine (hemisulfate)
T7942CAS 13492-01-8
Tranylcypromine is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1)  with a rapid onset of activity.
Salvigenin
TMS1743CAS 19103-54-9
Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
T5887CAS 22246-18-0
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone (7-​Hydroxy-​3,​4-​dihydro-​2(1H)​-​quinolinone) is a weak MAO-A inhibitor(with an IC50 of 183 μM) .
Purpurin
T5648CAS 81-54-9
Purpurin was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative ...
(Z)-SU4312
T5676CAS 90828-16-3
(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
N-(2-Aminoethyl)-5-chlor-2-pyridincarbox
T5678CAS 103878-83-7
N-(2-Aminoethyl)-5-chlor-2-pyridincarbox is a reversible and selective mao-b inhibitor(Ki:7.9nM).
LAZABEMIDE
T5470CAS 103878-84-8
LAZABEMIDE(Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).
Allylthiourea
T0418CAS 109-57-9
Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.