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Metabolism Glucokinase

Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.
Cat No. product name
T22223 3PO 3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines...
T6723 Voglibose Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and variou...
TWS0787 Oroxin A Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity agains...
T3S1612 Kuwanon G 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for...
T6S0535 Pinoresinol diglucoside 1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
T6S1371 Isovitexin 1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
TL0008 Gigantol Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-...
T3S2072 N-Butylidenephthalide 1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-gluc...
T6S2122 Ginkgolic acid C13:0 1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.
T7028 LICOCHALCONEC Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, an...
T4049 Genz-123346 free base Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
T4280 LTI291 LTI-291 is a glucocerebrosidase (Gcase) activator.
T3235 Rebaudioside A Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
T5690 4',7-DIMETHOXY-5-HYDROXYFLAVONE 4',7-DIMETHOXY-5-HYDROXYFLAVONE can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre...
T0247 Acarbose Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity.
T0714 Oxfendazole Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
T3386 Kaempferitrin Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
T3871 Sitogluside Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprote...
T2455 PFK015 PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T3675 1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
T3105 PFK158 PFK-158 is an effective and specific inhibitor PFKFB3.
T3312 AM2394 AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incre...
T3260 (E)-3PO (E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
T3104 LY2608204 LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T5489 Tryptophan, N-indol-3-ylacetyl- (6CI) Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may...
TQ0055 AMG-3969 AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
T8986 ML198 ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
T11741 KAN0438757 KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
T21344 Duvoglustat hydrochloride Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of po...
TN5192 Tuberosin Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner...
TN5094 Tangshenoside I Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
TN5090 Tachioside Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, show...
TN4793 Pinoresinol diacetate Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
TN4174 Guajadial Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Rece...
TN3745 Cyclomusalenone Cyclomusalenone is a potent α-glucosidase inhibitor.
TN3487 Balanophonin Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial a...
T16480 PF-04991532 PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
T11749 KDM4-IN-2 KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
T10751 Cefetrizole Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
TQ0300 Conduritol B epoxide Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
T13130 Terphenyllin Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
T15159 Dorzagliatin Dorzagliatin is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
T14365 AZ PFKFB3 26 AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1]. AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kina...
T14212 AMG-1694 AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM,...
T12142 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
T12056 MK-0941 free base MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
TN1451 Brevifolincarboxylic acid Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T8319 Butyl isobutyl phthalate Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
T8202 Kaempferol 3-gentiobioside Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a...
T8260 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
TQ0308 Castanospermine Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
T6759 AP-III-a4 AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.
3PO
T22223CAS 18550-98-6
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines...
Voglibose
T6723CAS 83480-29-9
Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and variou...
Oroxin A
TWS0787CAS 31567-75-6
Oroxin A is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity agains...
kuwanon G
T3S1612CAS 75629-19-5
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for...
Pinoresinol diglucoside
T6S0535CAS 63902-38-5
1. Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
Isovitexin
T6S1371CAS 38953-85-4
1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
Gigantol
TL0008CAS 67884-30-4
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-...
n-Butylidenephthalide
T3S2072CAS 551-08-6
1. (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-gluc...
Ginkgolic acid C13:0
T6S2122CAS 20261-38-5
1.Ginkgolic acid C13: 0exhibits the highest α-glucosidase inhibitory activity.
LICOCHALCONEC
T7028CAS 144506-14-9
Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, an...
Genz-123346 free base
T4049CAS 491833-30-8
Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
LTI291
T4280CAS 1919820-28-2
LTI-291 is a glucocerebrosidase (Gcase) activator.
Rebaudioside A
T3235CAS 58543-16-1
Rebaudioside A is a novel agent of glycoside clathration of pharmacons, acts as α-glucosidase inhibitor.
4',7-DIMETHOXY-5-HYDROXYFLAVONE
T5690CAS 5128-44-9
4',7-DIMETHOXY-5-HYDROXYFLAVONE can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre...
Acarbose
T0247CAS 56180-94-0
Acarbose is an inhibitor of α-Glucosidases with antihyperglycemic activity.
Oxfendazole
T0714CAS 53716-50-0
Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
Kaempferitrin
T3386CAS 482-38-2
Kaempferitrin has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against...
Sitogluside
T3871CAS 474-58-8
Eleutheroside A (Daucosterol) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol has efficient and inexpensive neuroprote...
PFK015
T2455CAS 4382-63-2
PFK-015 is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
1-Deoxynojirimycin
T3675CAS 19130-96-2
1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
PFK158
T3105CAS 1462249-75-7
PFK-158 is an effective and specific inhibitor PFKFB3.
AM2394
T3312CAS 1442684-77-6
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 incre...
(E)-3PO
T3260CAS 13309-08-5
(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
LY2608204
T3104CAS 1234703-40-2
LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
Tryptophan, N-indol-3-ylacetyl- (6CI)
T5489CAS 57105-53-0
Indole-3-acetyl-L-tryptophan is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may...
AMG-3969
TQ0055CAS 1361224-53-4
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
ML198
T8986CAS 1380716-06-2
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
KAN0438757
T11741CAS 1451255-59-6
KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
Duvoglustat hydrochloride
T21344CAS 73285-50-4
Duvoglustat is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of po...
Tuberosin
TN5192CAS 41347-45-9
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner...
Tangshenoside I
TN5094CAS 117278-74-7
Tangshenoside I might be a potential bioactive marker related to the hematopoietic and immunologic functions of Codonopsis Radix, which could be recommended as t...
Tachioside
TN5090CAS 109194-60-7
Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, show...
Pinoresinol diacetate
TN4793CAS 32971-25-8
Pinoresinol diacetate inhibits the enzyme α-glucosidase in vitro and may therefore act as a hypoglycemic agent.
Guajadial
TN4174CAS 959860-49-2
Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Rece...
Cyclomusalenone
TN3745CAS 30452-60-9
Cyclomusalenone is a potent α-glucosidase inhibitor.
Balanophonin
TN3487CAS 118916-57-7
Balanophonin shows potent α-glucosidase inhibitory activity, it has antioxidant, and anti-cancer activities. (±)-Balanophonin shows significant antibacterial a...
PF-04991532
T16480CAS 1215197-37-7
PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
KDM4-IN-2
T11749CAS 2369607-62-3
KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.
Cefetrizole
T10751CAS 65307-12-2
Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).
Conduritol B epoxide
TQ0300CAS 6090-95-5
Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
Terphenyllin
T13130CAS 52452-60-5
Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
Dorzagliatin
T15159CAS 1191995-00-2
Dorzagliatin is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
AZ PFKFB3 26
T14365CAS 1704740-52-2
AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1]. AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kina...
AMG-1694
T14212CAS 1361217-07-3
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM,...
N-Caffeoyl O-methyltyramine
T12142CAS 189307-47-9
N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
MK-0941 free base
T12056CAS 752240-01-0
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
Brevifolincarboxylic acid
TN1451CAS 18490-95-4
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
Butyl isobutyl phthalate
T8319CAS 17851-53-5
Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
Kaempferol 3-gentiobioside
T8202CAS 22149-35-5
Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. It possesses activity against α-glucosidase and displays a...
4',5-Dihydroxyflavone
T8260CAS 6665-67-4
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
Castanospermine
TQ0308CAS 79831-76-8
Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
AP-III-a4
T6759CAS 1177827-73-4
AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.