Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.

Cat. No.	Product name	CAS No.	Purity
T10694	CB1 inverse agonist 1	852315-00-5	98%
T10694	CB1 inverse agonist 1 is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows ...
T13081	Taranabant racemate	701977-00-6	98%
T13081	Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
T64371	Virodhamine		98%
T64371	Virodhamine, an endocannabinoid, is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine can be used for the research of neurological disord...
T14504	BAY 38-7271	212188-60-8	98%
T14504	BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM an...
T10510	CB1 antagonist 1	890037-68-0	98%
T10510	CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, and gast...
T17027	Tedalinab	916591-01-0	98%
T17027	Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab ...
T16928	SR144528	192703-06-3	98%
T16928	SR144528 is an effective and selective antagonist of the CB2 receptor (Ki: 0.6 nM).
T22009	CB2 receptor agonist 2	1314230-75-5	98%
T22009	CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high affinity and sel...
T21861	Drinabant	358970-97-5	98%
T21861	Drinabant is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-...
T14302	Olorinab	1268881-20-4	98%
T14302	Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
T13289	EHP-101	1818428-24-8
T13289	VCE-004.8 is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. VCE-004.8 attenuates adipogenesis and prevents diet-induc...
T8511	TM38837	1253641-65-4	100%
T8511	TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
TN3575	(±)-Cannabichromene	20675-51-8	96.89%
TN3575	Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 ...
T9114	β-Caryophyllene	87-44-5	97.31%
T9114	β-Caryophyllene acts as an CB2 receptor agonist.
T1915	AM251	183232-66-8	97.88%
T1915	AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
T2635	Org 27569	868273-06-7	98%
T2635	Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and e...
T5996	CB1-IN-1	1429239-98-4	98%
T5996	CB1-IN-1 is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T7375	A-836339	959746-77-1	98%
T7375	A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 recep...
T28468	PSNCBAM-1	877202-74-9	98.18%
T28468	PSNCBAM-1 is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo. PSNCBAM-1 can be used for obesity studies.
T7316	LY2828360	1231220-79-3	98.61%
T7316	LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, ...