Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryJapanJapan
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

ADC Cytotoxin

  • Dexamethasone
    T107650-02-2
    Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced inflammatory responses in macrophages.
    • $45
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Doxorubicin hydrochloride
    T102025316-40-9
    Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Mertansine
    T1992139504-50-0
    Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Paclitaxel
    T096833069-62-4
    Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Methotrexate
    T148559-05-2
    Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
    • $38
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Exatecan Mesylate
    TQ0088169869-90-3
    Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
    • $29
    In Stock
    Size
    QTY
  • Camptothecin
    T11237689-03-4
    Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
    • $46
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • 7-Epi 10-desacetyl paclitaxel
    T573878454-17-8
    7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
    • $110
    In Stock
    Size
    QTY
  • Aldoxorubicin hydrochloride
    T11090L11361563-03-2In house
    Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.
    • $57
    In Stock
    Size
    QTY
  • Taltobulin trifluoroacetate
    T13073228266-41-9In house
    Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
      7-10 days
      Inquiry
      TargetMol | Inhibitor Sale
    • (4-NH2)-Exatecan
      T401592495742-21-5In house
      (4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).
      • $123
      In Stock
      Size
      QTY
      TargetMol | Inhibitor Sale
    • DRF-1042
      T15168200619-13-2In house
      DRF-1042 is an orally active camptothecin analog with antitumor activity and inhibits DNA topoisomerase I. It is used in the study of refractory tumors.
      • $30
      In Stock
      Size
      QTY
    • Glucocorticoid receptor agonist-1
      T379082166375-82-0In house
      Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM[1].
      • $226
      In Stock
      Size
      QTY
    • Doxorubicin
      T145623214-92-8
      Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
      • Inquiry Price
      Size
      QTY
      TargetMol | Citations Cited
    • Aldoxorubicin
      T11090L1361644-26-9
      Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
      TargetMol | Citations Cited
    • Daunorubicin hydrochloride
      T151123541-50-6
      Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
      • $31
      In Stock
      Size
      QTY
      TargetMol | Citations Cited
    • SN-38
      T170386639-52-3
      SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.
      • $39
      In Stock
      Size
      QTY
      TargetMol | Citations Cited
    • Monomethyl auristatin E
      T6897474645-27-7
      Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
      • $41
      In Stock
      Size
      QTY
      TargetMol | Citations Cited
    • Eribulin
      T13688253128-41-5
      Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
      • $420
      In Stock
      Size
      QTY
    • DC1
      T10970169901-27-3
      DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Hygrolidin
      T3824383329-73-1
      Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).
      • $1,520
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • PNU-159682 carboxylic acid
      T195231204819-92-0
      PNU-159682 carboxylic acid is a potent ADCs cytotoxin,PNU-159682 carboxylic acid has protein fold and diverse functions.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Fmoc-MMAF-OMe
      T82382863971-38-4
      Fmoc-MMAF-OMe is a tubulin polymerization inhibitor and anticancer agent featuring an Fmoc protecting group. Its active component, MMAF, serves as the cytotoxic (ADC Cytotoxin) element in conventional antibody-drug conjugates (ADCs) [1].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • DGN462
      T110171394079-41-4
      DGN462 is an effective DNA alkylating agent with anti-tumor activity, as in acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs).
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Hemiasterlin
      T32055157207-90-4
      Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Luisol A
      T73915225110-59-8
      Luisol A, an aromatic tetraol and anthraquinone antibiotic analog, serves as a significant metabolite produced by an estuarine marine actinomycete from the genus Streptomyces. Additionally, it functions as an ADC (Antibody-Drug Conjugate) cytotoxin [1].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Duocarmycin A
      T15180118292-34-5
      Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
      • $1,520
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • γ-Amanitin
      T3956221150-23-2
      γ-Amanitin, an ADC (antibody-drug conjugate) cytotoxin isolated from mushrooms, inhibits RNA polymerase II, disrupting mRNA synthesis. It exhibits effects akin to those of α-Amanitin and β-Amanitin.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • ε-Amanitin
      T3964921705-02-2
      ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity.
      • $1,988
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Tubulysin IM-2
      T384301032072-50-6
      Tubulysin IM-2 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins .
      • $1,520
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Polyketomycin
      T12517200625-47-4
      Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, has antibacterial, anticancer, antimalarial activities.
      • $1,520
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Fmoc-MMAE
      T40568474645-26-6
      Fmoc-MMAE, a protective group-conjugated variant of monomethyl auristatin E (MMAE), serves as a powerful inhibitor of tubulin. It finds application in the synthesis of antibody-drug conjugates (ADC).
      • $87
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Rebeccamycin
      T1672693908-02-2
      Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
      • $445
      35 days
      Size
      QTY
      TargetMol | Inhibitor Sale
    • β-Amanitin
      T1347421150-22-1
      β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom, and inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis.
      • $900
      35 days
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Tubulysin A
      TQ0112205304-86-5
      Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • sulfo-DGN462 sodium
      T388231401203-09-5
      Sulfo-DGN462 sodium undergoes degradation to DGN462 when subjected to culture medium and plasma. DGN462, a highly effective DNA-alkylating agent, exhibits anti-tumor properties that are particularly active against acute myeloid leukemia (AML).
      • $1,520
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Suicin 65
      T81071
      Suicin 65, a class I type B lantibiotic synthesized by Streptococcus suis, exhibits activity against all S. suis isolates [1].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • DM3
      T11058796073-54-6
      DM3 (Maytansinoid DM3) is a maytansine mimic containing disulfide or thiol groups and a tubulin inhibitor. It is the cytotoxic part of antibody-drug conjugates (ADCs) .
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Tomaymycin DM
      T77814945490-09-5
      Tomaymycin DM, a derivative of Tomaymycin, functions as a DNA alkylator and PBD dimer. It is utilized to formulate antibody-drug conjugates (ADCs) by attaching to tumor-targeting antibodies.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • 7Ethanol-10NH2-11F-Camptothecin
      T832442873460-31-0
      7Ethanol-10NH2-11F-Camptothecin, an antibody drug conjugate (ADC), demonstrates inhibitory effects on tumor growth and is utilized in cancer research [1].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Hemiasterlin derivative-1
      T393201887046-60-7
      Hemiasterlin Derivative-1, a derivative of hemiasterlin, is utilized in the synthesis of Antibody-Drug Conjugates (ADC).
      • $1,520
      Backorder
      Size
      QTY
      TargetMol | Inhibitor Sale
    • 10NH2-11F-Camptothecin
      T834682873460-30-9
      10NH2-11F-Camptothecin, an antibody-drug conjugate (ADC), exhibits antitumor activity and is utilized in cancer research [1].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Duostatin 5
      T778412124210-34-8
      Duostatin 5 (Duo-5) is a sea hare toxin analog commonly used in the synthesis of ADC compounds.
      • $213
      In Stock
      Size
      QTY
      TargetMol | Inhibitor Sale
    • CC-885-CH2-PEG1-NH-CH3
      T403432722698-03-3
      CC-885-CH2-PEG1-NH-CH3 is a neoDegrader compound employed for the production of Antibody neoDegrader Conjugate (AnDC) during synthesis.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Tubulysin D
      T13228309935-57-7
      Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Duocarmycin SA
      T11118130288-24-3
      Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Aminohexylgeldanamycin hydrochloride
      T385221146534-45-3
      Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • Docetaxal
      T38644125354-16-7
      Docetaxal, also known as 10-Acetyl docetaxel, is an analog of Docetaxel exhibiting potent anticancer properties. It acts as a microtubule disassembly inhibitor, effectively inhibiting mitosis.
      • $497
      35 days
      Size
      QTY
      TargetMol | Inhibitor Sale
    • PBD dimer-2
      T84765145325-57-1
      PBD dimer-2 (compound 2c), a C8-linked pyrrolobenzodiazepine dimer, has the capability to span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. It serves as a potential payload for antibody–agent conjugates (ADCs) and is under research for cancer treatments [1] [2].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale
    • 7-Aminomethyl-10-methyl-11-fluoro camptothecin
      T778202378616-23-8
      7-Aminomethyl-10-methyl-11-fluoro camptothecin, serving as a cytotoxic component of the antibody-drug conjugate (ADC) MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin, is employed in the synthesis of camptothecin ADCs [1].
      • Inquiry Price
      Size
      QTY
      TargetMol | Inhibitor Sale