toxic

Deltamethrin (RU 22974), a neurotoxic pyrethroid insecticide, produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis.Deltamethrin is globally used in crop protection, control of malaria and other vector-borne diseases. It is easily degradable.

orcinol (5-Methylresorcin) is anxiolytic agent without sedative effect.

Aflatoxin (Aflatoxin R0) is a mutagenic and carcinogenic mycotoxin that is derived from aflatoxin B1 through metabolic processes facilitated by Rhizopus spp.

Toxicarol isoflavone, an iso avone, is extracted from Millettia brandisiana.

Vincetoxicoside B, isolated from Polygonum paleaceum Wall. Vincetoxicoside B , quercetin, kaempferol , and (-)-epicatechin show synergistic antifungal activities with the FICI values <0.5.

Alpha-Toxicarol exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

Dehydrotoxicarol is a natural product of Derris, Fabaceae. The catalog number is TN3811 and the CAS number is 59086-93-0. Dehydrotoxicarol can be used as a reference standard.

Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.

Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally but has been used orally for various fungal and parasitic infections and an anti-diarrheal.

5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.

5,6-Dihydroxyindole (Dopamine lutine) is a melanin precursor and has a broad-spectrum antibacterial, antiviral, antifungal, antiparasitic activity. It has cytotoxic effects and is strongly toxic against various pathogens.

Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

Stearamide(Stearic acid amide) is a primary fatty acid amide that is cytotoxic and fish toxic and can be used to increase the properties of nanoparticles.

N-Acetylglycine is a minor constituent of food that is not genotoxic or acutely toxic and is capable of being used in biological studies of mimetic peptides.N-Acetylglycine acts as a blocker of the N-terminus of a peptide.3-Hydroxyanthranilic acid is a competitive succinate dehydrogenase inhibitor.

D-Glucuronic acid sodium salt monohydrate (Sodium D-glucuronate) is a carboxylic acid that is highly soluble in water. In humans, glucuronic acid often binds to toxic substances to facilitate elimination and to hormones to aid in their transport.

N-(5-Aminopentyl)acetamide (N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine. Cadaverine is produced by the breakdown of amino acids in living and dead organisms and is toxic in large doses. N-(5-Aminopentyl)acetamide is a promising biochemical marker for cancer and many other pathophysiological conditions.

Ethylmalonic acid is potentially toxic, non-carcinogenic, and has been associated with anorexia nervosa and methoxy decarboxylase deficiency.

p-Benzoquinone is a superoxide scavenger. It is identified as a toxic metabolite in human blood.

L-Azetidine-2-carboxylic acid ((2S)-azetidine-2-carboxylic acid) is a toxic proline analogue produced by members of the Liliaceae and Agavaciae families.

2,6-Diphenylpyridine is toxic to MDA-MB-231 cells and has anticancer potential.

Cantharidin, a natural toxin found in beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth.

Spirostan-3-ol (Sarsaponin) is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis.

1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a significant decrease in the severity of liver fibrosis and the absence of cirrhotic transformation of the liver. 2. Betulonic acid derivatives have a promising cytostatic activity in vitro and could be used as potential leads for the development of new type of anti-cancer agents. 3. Betulonic acid has antiholestatic effects in mice.

Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecul