Search Result

Search Results for " retinal "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T38219	11-cis Retinal
	11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to for...
T39280	Nitrofen		Others
	Nitrofen is a selective contact herbicide. Nitrofen is a protoporphyrinogen oxidase and retinal dehydrogenase inhibitor.		Others
T2055	WS3		EGFR , IκB/IKK
	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.		EGFR , IκB/IKK
T2026	CYM5442		S1P Receptor , LPL Receptor
	CYM5442 is an S1P agonist, targeting to Sphingosine.		S1P Receptor , LPL Receptor
T21807	INCA-6	Triptycene-1,4-quinone	Others
	INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site.		Others
T5194	SPHINX31		Serine/threonin kinase
	SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).		Serine/threonin kinase
T29395	3-Diazirinophenylretinal
	3-Diazirinophenylretinal is a bioactive chemical.
T34299	Retinaloxime	trans-Retinaloxime
	Retinaloxime is a retinoid.
T25829	Mopidamol	RA233,RA 233,RA-233,Rapenton,OLX 102	PDE
	Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental diabetes.		PDE
T62858	HGPR91 antagonist 3		GPR
	hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be...		GPR
T5913	Sulbutiamine	Bisibuthiamine	Antioxidant
	Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.		Antioxidant
T30480	BiP inducer X	BIX	Apoptosis
	BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.		Apoptosis
T22282	Brr2-IN-3	Brr2 Inhibitor 9,Brr2 Inhibitor C9	Others
	Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa (a group of progressive retinal degenerative disorders).		Others
T72662	NMDAR/TRPM4-IN-2		ERK , TRP/TRPV Channel , NMDAR , iGluR
	NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot...		ERK , TRP/TRPV Channel , NMDAR , iGluR
T13524	9-cis-β-Carotene		Others
	9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo.		Others
T37081	HIOC
	Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
TP2393	Neurotensin-related hexapeptide	Lant-6
	Neurotensin-related hexapeptide exists in retinal ganglion cells and in their central projections in pigeons and may be utilized as a neuroactive substance by the central terminals of numerous retinal ganglion cells in b...
T71715	CU239
	CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration.
T71488	Cremastranone
	Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.
T69972	ONL-1204
	ONL-1204 is a small molecule, CD95 antigen inhibitor (Fas inhibitor) being developed by ONL Therapeutics for the treatment of retinal detachment.
T28487	Quininib
	Quininib is a regulator of Ocular Angiogenesis. Quininib significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice.
T40680	[Tyr11]-Somatostatin	[Tyr11]-Somatostatin
	[Tyr11]-Somatostatin is a neuroactive peptide utilized in proteomics research. It belongs to a class of neuroactive substances that play a role in modulating retinal physiology.
T10408	ATWLPPR Peptide TFA		Others
	ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes.		Others
T70329	SH-11037
	SH-11037 is a novel potent seh inhibitor, effectively blocking key angiogenic properties of human retinal endothelial cells (hrecs), inhibiting choroidal sprouting and significantly suppressing cnv lesion volume
T68547	SNJ-1945
	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) ...
T73476	YC-001
	YC-001, an inverse agonist and antagonist of rod opsin, reversibly binds and stabilizes the rod opsin structure. This compound demonstrates protective effects against bright light-induced retinal degeneration in mice, su...
T78404	Pyridinium bisretinoid A2E TFA	A2E TFA	Apoptosis
	Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates autophagy, and generates reactive oxygen species. This compou...		Apoptosis
T29809	AL-1	AL 1,AL1
	AL-1 is a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It can mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It exists in a variet...
T81341	Pyr-Gly
	Pyr-Gly is an inhibitory peptide that suppresses the proliferation of retinal pigment epithelium (RPE) cells and fibroblasts [1].
T36617	Ent-8-iso Prostaglandin F2α	ent-8-iso Prostaglandin F2α
	ent-8-iso Prostaglandin F2α is a potent vasoconstrictor of porcine retinal and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively.
T37453	Butyryl-L-carnitine (chloride)
	Butyryl-L-carnitine is a butyrate ester of carnitine. It is an inhibitor of intestinal transporters, blocking carnitine uptake by the carnitine transporter and glycine transport by the amino acid transporter in human ret...
T71722	Angiogenesis inhibitor BT2
	Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, ang...
T76574	Arginyl-Glutamine
	Arginyl-Glutamine, a dipeptide, has been shown to reduce VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy [1].
T79080	ROCK-IN-7		ROCK
	ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].		ROCK
T35889	PB2
	PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficac...
T38220	11-cis Retinol
	11-cisRetinol is an isomer of vitamin A . It is formed from vitamin A,viaatrans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual...
T79077	ROCK-IN-6		ROCK
	ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1].		ROCK
T80443	ω-Conotoxin MVIID	SNX-238	Calcium Channel
	ω-Conotoxin MVIID (SNX-238) is a peptide from the Conus genus that inhibits the ω-Conotoxin-GVIA-sensitive, high-threshold calcium (Ca 2+) current in fish retinal ganglion cells [1].		Calcium Channel
T37820	Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)
	Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retin...
T76987	Tarcocimab
	Tarcocimab (OG1953), a humanized IgG1-type anti-VEGFA monoclonal antibody, is utilized in research targeting conditions such as retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD).
T69990	Ruboxistaurin mesylate monohydrate
	Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and...
T83681	IRBP (1-20) (human, rat) TFA	IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20), a dodecapeptide fragment of retinoid-binding protein 3, plays a crucial role in pigment regeneration by facilitating the transport of retinol and retinal bet...
T38462	PF-04577806
	PF-04577806 is a potent, selective, and ATP competitive inhibitor of the protein kinase C (PKC). It exhibits significant inhibitory activity against various isoforms of PKC, including PKCα, PKCβI, PKCβII, PKCγ, and PKCθ,...
T3689L	Ruboxistaurin mesylate	LY-333531,LY333531,LY 333531,LY-333531 Mesylate
	Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne...
T61604	PKC-IN-4
	PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-...
T37577	Glycogen Phosphorylase Inhibitor
	Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibit...
T74699	Avacincaptad pegol
	Avacincaptad pegol, a pegylated aptamer, stands out as an effective C5 complement inhibitor capable of mitigating inflammation-induced damage to the retinal pigment epithelium (RPE). This compound is under investigation ...
T83700	IRBP (651-670) (human) TFA	IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)
	Interphotoreceptor retinoid-binding protein (651-670) (IRBP651-670), a peptide fragment of retinoid-binding protein 3 (also known as IRBP), plays a crucial role in the visual cycle by facilitating the transport of retino...
T35888	PB1
	PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable st...
T83691	EGFR Peptide (human, mouse) TFA	Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH,Epidermal Growth Factor Receptor Peptide
	EGFR peptide, a PKC peptide substrate, mirrors an amino acid sequence from EGFR's intracellular region and serves to gauge PKC activity in primary bovine retinal endothelial cells. At a concentration of 50 µM, unlike its...

Compounds

Target: EGFR, IκB/IKK

CYM5442

T2026

Synonym:

Target: S1P Receptor, LPL Receptor

INCA-6

T21807

Synonym: Triptycene-1,4-quinone

Target: Serine/threonin kinase

3-Diazirinophenylretinal

Synonym: trans-Retinaloxime

Target:

Mopidamol

T25829

Synonym: RA233,RA 233,RA-233,Rapenton,OLX 102

Synonym: Bisibuthiamine

Synonym: Brr2 Inhibitor 9,Brr2 Inhibitor C9

Target: ERK, TRP/TRPV Channel, NMDAR, iGluR

Neurotensin-related hexapeptide

Synonym: [Tyr11]-Somatostatin

Pyridinium bisretinoid A2E TFA

ent-8-iso Prostaglandin F2α

T36617

Synonym: ent-8-iso Prostaglandin F2α

Target:

Butyryl-L-carnitine (chloride)

T37453

Synonym:

Target:

Angiogenesis inhibitor BT2

Target: Calcium Channel

Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)

Ruboxistaurin mesylate monohydrate

T69990

Synonym:

Target:

IRBP (1-20) (human, rat) TFA

T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

Ruboxistaurin mesylate

T3689L

Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Glycogen Phosphorylase Inhibitor

IRBP (651-670) (human) TFA

T83700

Synonym: IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)

EGFR Peptide (human, mouse) TFA

T83691

Synonym: Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH,Epidermal Growth Factor Receptor Peptide

Target:

Cat No.	Product Name	Synonyms	Targets
T5256	All-trans-retinal	All trans-Retinal,Retinaldehyde,Vitamin A aldehyde	Others , Endogenous Metabolite
	All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.		Others , Endogenous Metabolite
T19169	9-cis-Retinal		Others
	9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and ma...		Others
T12095	Monomethyl fumarate		GPR , Drug Metabolite
	Monomethyl fumarate is a potent agonist of GPR109A .		GPR , Drug Metabolite
T0685	Retinyl acetate	Vitamin A acetate,Retinyl (Retinol) Acetate,Retinol acetate
	Retinyl acetate (Vitamin A acetate) is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most importan...
T40942	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone
	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, an antiangiogenic homoisoflavonoid, exhibits activity against human retinal microvascular endothelial cells.
T75608	Myricetin 3-O-α-L-arabinopyranoside
	Myricetin 3-O-α-L-arabinopyranoside, a quercetin derivative and plant flavonoid, exhibits antioxidant, antibacterial, and antiurease properties. It inhibits A2E photooxidation-induced retinal pigment epithelium (RPE) cel...
TQ0199	Ginsenoside Rh3		Antioxidant , Nrf2 , Antifungal
	Ginsenoside Rh3 is a natural product extracted from Ginseng C. A. Mey.Ginsenoside Rh3 has antifungal and antioxidant activities and induces Nrf2 activation in human retinal cells.		Antioxidant , Nrf2 , Antifungal
T10348	Apigenin-7-diglucuronide		Others
	Apigenin-7-diglucuronide is a flavonoid glycoside that exists in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. It protects retinas against bright light-induced photoreceptor degenera...		Others
T38179	C16 3'-sulfo Galactosylceramide (d18:1/16:0)	C16 3'-sulfo Galactosylceramide (d18:1/16:0)	Others
	C16 3'-sulfo Galactosylceramide (d18:1/16:0) is a sulfated glycolipid.C16 3'-sulfo Galactosylceramide (d18:1/16:0) is a relatively abundant sulfide found in porcine brain and plasma that decreases throughout development ...		Others

Natural Products

All-trans-retinal

T5256

Synonym: All trans-Retinal,Retinaldehyde,Vitamin A aldehyde

Target: Others, Endogenous Metabolite

Target: GPR, Drug Metabolite

Retinyl acetate

T0685

Synonym: Vitamin A acetate,Retinyl (Retinol) Acetate,Retinol acetate

Target:

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone

T40942

Synonym:

Target:

Myricetin 3-O-α-L-arabinopyranoside

Target: Antioxidant, Nrf2, Antifungal

Apigenin-7-diglucuronide

T10348

Synonym:

Target: Others

C16 3'-sulfo Galactosylceramide (d18:1/16:0)

T38179

Synonym: C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00142	ROM1 Protein, Human, Recombinant (His)	Human	E. coli
	ROM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18 kDa and the accession number is Q03395.
TMPJ-01134	CLUL1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Clusterin-Like Protein 1 (CLUL1) is a secreted protein that belongs to the clusterin family. CLUL1 is synthesized as a 466 amino acid precursor that contains a 20 amino acid signal sequence, and a 446 amino acid mature c...
TMPY-01052	R-Cadherin/CDH4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) region...
TMPJ-00710	ALDH1A2 Protein, Human, Recombinant (His)	Human	E. coli
	Aldehyde dehydrogenase 1 family member A2 (ALDH1A2), also known as retinaldehyde dehydrogenase 2 (RALDH2), belongs to the aldehyde dehydrogenase family which contains two members, the ALDH1 s (ALDH1A1, ALDH1A2 and ALDH1A...
TMPY-02525	RGMA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th...
TMPK-00360	DLL4 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell pro...
TMPY-03310	Frizzled 4 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EV...
TMPY-00197	Frizzled 4 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EV...
TMPY-00313	Frizzled 4 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EV...
TMPY-04302	Frizzled 4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EV...
TMPK-00417	MERTK/Mer Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-00418	MERTK/Mer Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-01022	MERTK/Mer Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPH-01952	SPRY2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgro...
TMPH-01201	DRD2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
TMPH-01615	OPN1LW Protein, Human, Recombinant (His)	Human	E. coli
	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. OPN1LW Protein, Human, Recombinant (His) is expressed in E. coli expression s...
TMPH-02060	SAG Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal...
TMPY-02377	14-3-3 eta/YWHAH Protein, Human, Recombinant (GST)	Human	E. coli
	YWHAH, the gene encoding the 14-3-3eta isoform, is highly expressed in retinal ganglion cells (RGC). YWHAH is a positional and functional candidate gene for both schizophrenia and bipolar disorder (BP). It is located on ...
TMPH-03332	OPN4 Protein, Rat, Recombinant (His)	Rat	E. coli
	Photoreceptor that binds cis-retinaldehydes. Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light. May be involved in the optokinetic visual tracking response. May be involved i...
TMPK-01153	PLVAP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such...
TMPH-03400	SLC17A6 Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vess...
TMPK-00893	PGF Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Retinal inhibition of PGF in combination with VEGF-A prevents vascular leakage and CNV pos...
TMPH-02842	CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epit...
TMPH-00300	Rhodopsin Protein, Bovine, Recombinant (His & KSI)	Bovine	E. coli
	Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-03124	Rhodopsin Protein, Pig, Recombinant (GST)	Sus scrofa (Pig)	E. coli
	Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-03123	Rhodopsin Protein, Pig, Recombinant (GST & His)	Sus scrofa (Pig)	E. coli
	Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-00299	Rhodopsin Protein, Bovine, Recombinant (His)	Bovine	E. coli
	Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change t...
TMPH-02135	SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiati...
TMPH-03203	FGFb Protein, Rabbit, Recombinant (His & SUMO)	Rabbit	E. coli
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell di...
TMPH-00916	ADH1B Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of al...
TMPH-02122	SLC2A1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most imp...
TMPH-00001	CD133/PROM1 Protein-VLP, Human, Recombinant (His)	Human	HEK293 Cells
	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epit...
TMPH-03373	SLC2A1 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most imp...
TMPJ-01130	NPTX1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a...
TMPY-01203	RP2 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	XRP2, also known as Protein XRP2 and RP2, is a member of the TBCC (tubulin cofactor C) family and contains one C-CAP/cofactor C-like domain. This protein is encoded by the RP2 gene in humans. XRP2 stimulates the GTPase a...
TMPJ-01055	HBA1 Protein, Human, Recombinant (His)	Human	E. coli
	Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the F...
TMPJ-00821	OM Protein, Human, Recombinant (His)	Human	E. coli
	Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macropha...
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
TMPY-02376	BNIP3L Protein, Human, Recombinant	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPJ-01143	MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)	Human	HEK293 Cells
	Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one...
TMPY-02289	CIB2 Protein, Human, Recombinant (His)	Human	E. coli
	Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is gen...
TMPY-02802	GNG13 Protein, Human, Recombinant (His)	Human	E. coli
	GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducer...
TMPY-00585	Annexin A8 Protein, Human, Recombinant (His)	Human	E. coli
	We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...