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Tau Peptide (275-305) (Repeat 2 domain)
T40409330456-25-2
Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.
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survivin (baculoviral IAP repeat-containing protein 5) (21-28)
TP2292
Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes
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IRBP acetate(211426-18-5 free base)
Interphotoreceptor Retinoid Binding Protein Fragment IRBP
TP1120L
IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visual pigment Binding Protein peptide (IRBP 161-180) and can induce post-uveitis (EAU).
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TargetMol | Inhibitor Sale
Hsp70-derived octapeptide acetate
Hsp70-derived octapeptide acetate(736171-62-3 free base)
TP1616L
Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate) is a group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus of hsc70-interacting protein (CHIP), TPR1 and human glutamine-rich TPR-containing protein (hSGT), on refolding of luciferase by DnaJ and hsc70 was investigated.
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TargetMol | Inhibitor Sale
SARS-CoV-2-IN-34
T76270
SARS-CoV-2-IN-34 (S-20-1) is a broad-spectrum pan-coronavirus (CoV) fusion inhibitor that penetrates the blood-brain barrier and exhibits extensive inhibitory activity against both pseudotyped and authentic SARS-CoV-2, as well as pseudotyped variants of concern (VOCs). It shows high affinity for the receptor-binding domain (RBD) in the S1 and the heptad repeat 1 (HR1) domain in the S2 of the SARS-CoV-2 spike (S) protein, making it a valuable tool for infection research [1].
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PHF6
T76652329897-62-3
PHF6 (VQIVYK), a sequence within the third microtubule-binding repeat region of the tau protein, initiates the aggregation of the full-length tau protein through its self-assembly capabilities [1].
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C34 peptide
T80264
C34 peptide, also referred to as HR2, is a biologically active peptide integral to the helical region of HIV's gp41 and is specifically the C-terminal heptad repeat 2 (HR2), denoted as the C helix or C peptide. It functions as a potent inhibitor of HIV-1 fusion, thereby impeding the virus's entry into cells via membrane fusion.
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Tat-NTS Peptide TFA
Tat-Nuclear Translocation Signal Peptide
T83727
Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear translocation signal (NTS). This peptide hinders the interaction between annexin A1 and importin β, obstructing annexin A1's nuclear entry in primary mouse hippocampal neurons. Tat-NTS effectively prevents apoptosis triggered by glucose-oxygen deprivation and reperfusion in these neurons. When administered in vivo at a dosage of 10 mg/kg, it significantly reduces infarct size, minimizes neuronal apoptosis, and improves navigation performance in the Morris water maze test for mice subjected to ischemia-reperfusion injury via middle cerebral artery occlusion (MCAO).
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BRC4wt TFA
T83854
BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide (Arg)9, it effectively shortens DNA replication tract lengths and diminishes the frequency of homologous repair of camptothecin-induced DNA damage in vitro. Additionally, BRC4wt enhances the efficacy of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib in inducing cell death in HeLa human cervical cancer and U2OS human osteosarcoma cells, albeit it does not affect non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells.
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Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)
IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP
TP1120211426-18-5
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP 161-180) is a 20-residue peptide that acts as a major pathogenic epitope, located in the first homologous repeat of interstitial visual pigment Binding Protein, and can induce post-uveitis (EAU).
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Hsp70-derived octapeptide
TP1616736171-62-3
A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus
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QPH-FR
TP3080
QPH-FR is a quinoa peptide and acts as an inhibitor of the G protein-coupled receptor 5 (LGR5) that is abundant in leucine repeat sequences. By binding to LGR5, QPH-FR competitively inhibits the formation of the LGR5 RSPO1 complex. This interaction leads to the ubiquitination of FZD receptors by RNF43 ZNRF3, thereby inhibiting the Wnt β-catenin signaling pathway and exerting stem cell suppression.
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