pdh

Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

1-Methoxy-4-propylbenzene exhibits antibacterial activity against Mycobacterium tuberculosis and inhibitory activity against PDH, making it suitable for the treatment of tuberculosis infections.

Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

Pipcroside B, found in P. crocatum Ruiz & Pav, serves as a pyruvate dehydrogenase (PDH) inhibitor with an IC50 of 99.82 µM. It exhibits antibacterial properties and is utilized in studies related to oral infections.

Pipcroside C can be found in P. crocatum Ruiz & Pav. It acts as an inhibitor of pyruvate dehydrogenase (PDH) with an IC50 value of 80.25 µM. Additionally, Pipcroside C exhibits antibacterial properties and is utilized in research related to oral infections.