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Search Results for " modifier "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T19257	Cys modifier 1		Others
	Cys modifier 1 (compound 7) is a cysteine-selective protein modifier for protein bioconjugation as well as a fluorescent carbonylacrylic derivative bearing nitrobenzofurazan (λ ex =465nm and λ em 539 nm) [1].		Others
T32102	HPG Protein Modifier
	HPG protein modifiers or p-hydroxyphenyl glyoxal react with arginine residues, producing an absorbance increase at about 340 nm, and are therefore a good choice for amino acid side chain modification.
TNU1282	N-(4-Isopropyloxy phenyl)-N-(1H-pyrrol-2-ylmethyl)urea; flavoring agent, flavor modifier
	N-(4-Isopropyloxy phenyl)-N-(1H-pyrrol-2-ylmethyl)urea; flavoring agent, flavor modifier is a useful organic compound for research related to life sciences and the catalog number is TNU1282.
T13748	L-2-Hydroxyglutaric acid disodium	(S)-2-Hydroxyglutaric acid disodium	Histone Demethylase , Mitochondrial Metabolism
	L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ...		Histone Demethylase , Mitochondrial Metabolism
T12718L	RG7800	RO6885247	Others , DNA/RNA Synthesis
	RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.		Others , DNA/RNA Synthesis
T19335	Danegaptide Hydrochloride	GAP-134 (Hydrochloride),ZP 1609 Hydrochloride	Gap Junction Protein
	Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.		Gap Junction Protein
T5199	COH000		E1/E2/E3 Enzyme
	COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).		E1/E2/E3 Enzyme
T6482	Efaproxiral Sodium	RSR13 sodium	Reactive Oxygen Species
	Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.		Reactive Oxygen Species
T25534	Indazole-Cl	Indazole Cl	Estrogen/progestogen Receptor
	Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).		Estrogen/progestogen Receptor
T64221	Linvencorvir	RG7907	HBV , Antibiotic
	Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.		HBV , Antibiotic
T27404	GAT107	GAT 107,GAT-107	AChR
	GAT107 is a novel and potent α7 nicotinic cholinergic receptor modifier agonist and modulator with anti-inflammatory activity that reverses injury perception in a mouse model of neuropathic pain.		AChR
T16757	Risdiplam	RO7034067,RG7916	DNA/RNA Synthesis
	Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1].		DNA/RNA Synthesis
T9493	DL-2-AMINOOCTANOIC ACID		Others
	DL-2-AMINOOCTANOIC ACID, also known as α-aminooctanoic acid or α-aminooctanoic acid, can be used as a modifier to modify Na-MMT clay.		Others
T0134	Imiquimod	R 837,S-26308	SARS-CoV , TLR , Autophagy , HSV
	Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.		SARS-CoV , TLR , Autophagy , HSV
T5521	Bropirimine	U-54461	TLR
	Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.		TLR
T34093	PNNP	p NNP,p-Nitrophenyl phosphate,p-NNP,Nitrophenylphosphate	Carbonic Anhydrase
	pNNP (Nitrophenylphosphate) can be used as a substrate for the PP2C assay. pNNP inhibits β-carbonic anhydrase and α-carbonate dehydrogenase, as well as H. pylori Helicobacter pylori. pNNP is a weakly active, tissue-nonsp...		Carbonic Anhydrase
TNU0355	N6-Methyl-2'-O-methyladenosine	N6,2′-O-Dimethyladenosine	Nucleoside Antimetabolite/Analog
	N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine), a substrate for adiposity and obesity-related genes (FTO), is a reversible modifier compound found on a wide variety of RNA molecules.N6,2′-O-Dimethyladenosine ...		Nucleoside Antimetabolite/Analog
T16102	ML-792		E1/E2/E3 Enzyme
	ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...		E1/E2/E3 Enzyme
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T14348	Auristatin E		Microtubule Associated
	Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an...		Microtubule Associated
T67883	EZH2-IN-15	SHR2554	Histone Methyltransferase
	EZH2-IN-15 is a specific inhibitor of histone modifier enhancer of zeste 2 (EZH2). EZH2 is aberrantly overexpressed in a number of human cancers that controls the adaptive response via regulation of Treg activity. Intrat...		Histone Methyltransferase
T32313	JP7	JP-7,JP 7
	JP7 is a hemoglobin allosteric modifier.
TP2348	Pimelautide	RP 44102,RP44102,RP-44102
	Pimelautide is a biological response modifier medicine.
T31609	Eisenin	Pglu-gln-ala,Pyroglutamyl-glutaminyl-alanine
	Eisenin shows the activity as a biological response modifier isolated from brown marine algae, Eisenia bicyclis Setchell.
T19468	Nafocare B1	Methylfurylbutyrolactone	Others
	Nafocare B1 is a modifier of synthetic immune biological response.		Others
T29260	(R)-ß-lysine	R ß lysine,MG1655,R-ß-lysine,(R) ß lysine,MG-1655
	(R) - ß - lysine is a functional modifier of elongation factor P (EF-P).
T19159	Mal-β-CD	6-O-alpha-D-Maltosyl-beta-cyclodextrin	Others
	Mal-β-CD is a cellular cholesterol modifier. It can form a soluble inclusion complex with cholesterol.		Others
T3645	Endoxifen E-isomer hydrochloride	E-Endoxifen hydrochloride	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride) , a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T26122	Ropizine	SC13504,Ropizina,SC-13504,SC 13504
	Ropizine is a benzhydryl piperazine that acts as an allosteric modifier to decreases the dissociation rate of [3H]DM so that can be used as an anticonvulsant.
T39810	CEM114
	CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effec...
T19336	Danegaptide	ZP 1609,GAP-134	Others
	Danegaptide (GAP-134), has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.a small modified dipeptide.		Others
T18319	MC-Val-Cit-PAB-Auristatin E		Others
	MC-Val-Cit-PAB-Auristatin E is an antibody-drug conjugate (ADC) linker compound featuring Auristatin E, a potent cytotoxic tubulin modifier, connected through the MC-Val-Cit-PAB linker, exhibiting significant antitumor a...		Others
T22862	Imiquimod maleate		Others
	Imiquimod maleate is an immune response modifier. It acts as a toll-like receptor 7 agonists and is commonly used topically to treat warts on the skin of the genital and anal areas.		Others
T19941	MBS Crosslinker	MBS protein crosslinker
	MBS crosslinker is a non-cleavable, water-insoluble, heterobifunctional protein crosslinking reagent. The MBS protein crosslinker extended spacer arm analog is SMPB crosslinker SATA Protein Modifier can be used to add su...
TP1531	Guangxitoxin 1E
	Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
T37646	HB007
	HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for in...
T74483	Aminobenzenesulfonic auristatin E
	Aminobenzenesulfonic auristatin E is a potent antitumor agent-linker conjugate for Antibody-Drug Conjugates (ADC). It utilizes Auristatin E (a cytotoxic tubulin modifier) connected through the ADC linker, Aminobenzenesul...
T80437	μ-TRTX-Hd1a		Sodium Channel
	μ-TRTX-Hd1a, a spider venom-derived compound, selectively inhibits the human NaV 1.7 channel by functioning as a gating modifier. It interacts with the S3b-S4 paddle motif within domain II of the channel [1].		Sodium Channel
T74484	Aminobenzenesulfonic auristatin E TFA
	Aminobenzenesulfonic Auristatin E TFA, an agent-linker conjugate for ADC, exhibits potent antitumor activity. It employs Auristatin E (a cytotoxic tubulin modifier) connected through the ADC linker Aminobenzenesulfonic [...
T22091	Imiquimod hydrochloride
	Imiquimod hydrochloride (R 837 hydrochloride), a selective toll-like receptor 7 (TLR7) agonist, functions as an immune response modifier with in vivo antiviral and antitumor properties. It is utilized in researching exte...
T39704	KSC-34		Others
	KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study d...		Others
T5499	Gardiquimod TFA salt
	Gardiquimod diTFA, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod diTFA could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically ...
T75855	Phrixotoxin 3 TFA
	Phrixotoxin 3 TFA is a potent inhibitor of voltage-gated sodium channels, demonstrating IC50 values of 0.6 nM for NaV1.2, 42 nM for NaV1.3, 72 nM for NaV1.4, 288 nM for NaV1.1, and 610 nM for NaV1.5, respectively. This c...

Compounds

HPG Protein Modifier

T32102

Synonym:

Target:

N-(4-Isopropyloxy phenyl)-N-(1H-pyrrol-2-ylmethyl)urea; flavoring agent, flavor modifier

TNU1282

Synonym:

Target:

L-2-Hydroxyglutaric acid disodium

T13748

Synonym: (S)-2-Hydroxyglutaric acid disodium

Target: Histone Demethylase, Mitochondrial Metabolism

RG7800

T12718L

Synonym: RO6885247

Target: Others, DNA/RNA Synthesis

Danegaptide Hydrochloride

T19335

Synonym: GAP-134 (Hydrochloride),ZP 1609 Hydrochloride

Target: Gap Junction Protein

COH000

T5199

Synonym:

Target: E1/E2/E3 Enzyme

Efaproxiral Sodium

T6482

Synonym: RSR13 sodium

Target: Reactive Oxygen Species

Indazole-Cl

T25534

Synonym: Indazole Cl

Target: Estrogen/progestogen Receptor

Linvencorvir

T64221

Synonym: RG7907

Target: HBV, Antibiotic

GAT107

T27404

Synonym: GAT 107,GAT-107

Target: AChR

Risdiplam

T16757

Synonym: RO7034067,RG7916

Target: DNA/RNA Synthesis

DL-2-AMINOOCTANOIC ACID

Synonym: R 837,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Synonym: p NNP,p-Nitrophenyl phosphate,p-NNP,Nitrophenylphosphate

Target: Carbonic Anhydrase

N6-Methyl-2'-O-methyladenosine

TNU0355

Synonym: N6,2′-O-Dimethyladenosine

Target: Nucleoside Antimetabolite/Analog

ML-792

T16102

Synonym:

Target: E1/E2/E3 Enzyme

Vesnarinone

T3465

Synonym: OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Auristatin E

T14348

Synonym:

Target: Microtubule Associated

EZH2-IN-15

T67883

Synonym: SHR2554

Target: Histone Methyltransferase

Synonym: RP 44102,RP44102,RP-44102

Target:

Eisenin

T31609

Synonym: Pglu-gln-ala,Pyroglutamyl-glutaminyl-alanine

Target:

Nafocare B1

T19468

Synonym: Methylfurylbutyrolactone

Target: Others

(R)-ß-lysine

T29260

Synonym: R ß lysine,MG1655,R-ß-lysine,(R) ß lysine,MG-1655

Target:

Mal-β-CD

T19159

Synonym: 6-O-alpha-D-Maltosyl-beta-cyclodextrin

Target: Others

Endoxifen E-isomer hydrochloride

T3645

Synonym: E-Endoxifen hydrochloride

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Ropizine

T26122

Synonym: SC13504,Ropizina,SC-13504,SC 13504

Synonym: ZP 1609,GAP-134

Target: Others

MC-Val-Cit-PAB-Auristatin E

Synonym: MBS protein crosslinker

Aminobenzenesulfonic auristatin E

Target: Sodium Channel

Aminobenzenesulfonic auristatin E TFA

T74484

Synonym:

Target:

Imiquimod hydrochloride

Cat No.	Product Name	Synonyms	Targets
T5043	Lentinan		Others
	Lentinan, isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.		Others
T20868	Isophthalic acid	Acide isophtalique
	Isophthalic acid is an intermediate for a modifier of polyethylene terephthalate for bottles, gel coats, high solids paints, resins for coatings, and high-performance unsaturated polyesters.
T13749	L-2-Hydroxyglutaric acid	(S)-2-Hydroxyglutaric acid	Others
	L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Ad...		Others
T39614	Mogroside VI A
	Mogroside VI A is a saccharide compound, an isomer of Mogroside VI, that has been extracted from the Luo Han Guo plant. It possesses inherent sweetness properties. Mogroside VI A holds potential for application in sweete...

Natural Products

Synonym: Acide isophtalique

Target:

L-2-Hydroxyglutaric acid

T13749

Synonym: (S)-2-Hydroxyglutaric acid

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06748	UBA6 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. The UBA6 gene, located on 4q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Uba6 is a homo...
TMPY-02348	ISG15 Protein, Human, Recombinant	Human	E. coli
	Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / ly...
TMPY-02467	ISG15 Protein, Human, Recombinant (mature form)	Human	E. coli
	Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / ly...
TMPY-02391	SUMO1 Protein, Human, Recombinant (His)	Human	E. coli
	Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific pro...
TMPJ-01022	SUMO3 Protein, Human, Recombinant (HEK293, His)	Human	Human Cells
	Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way...
TMPJ-01324	UBA5 Protein, Human, Recombinant (His)	Human	E. coli
	UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. T...
TMPJ-01021	SUMO3 Protein, Human, Recombinant	Human	E. coli
	SUMO3 belongs to the SUMO protein family and operates like ubiquitin. Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polyer. Nevertheless unlike ubiqui...
TMPJ-01023	SUMO3 Protein, Human, Recombinant (E.coli, His)	Human	E. coli
	SUMO3 belongs to the SUMO protein family and operates like ubiquitin. Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polyer. Nevertheless unlike ubiqui...
TMPJ-00486	SUMO2 Protein, Human, Recombinant (His)	Human	E. coli
	Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target p...
TMPY-02840	Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cl...
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in t...
TMPH-01684	MAP1LC3C Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p...
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST)	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin ho...
TMPY-03332	PRTFDC1 Protein, Human, Recombinant (His)	Human	E. coli
	PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG ...
TMPY-00583	ADPRH Protein, Human, Recombinant (His)	Human	E. coli
	Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water an...
TMPH-01815	Optineurin Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role i...
TMPH-01814	Optineurin Protein, Human, Recombinant (His)	Human	Baculovirus
	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role i...
TMPH-00818	Delta-theraphotoxin-Hm1a Protein, Heteroscodra maculata, Recombinant (His & Myc & SUMO)	Heteroscodra maculata	E. coli
	Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM...