internalization — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9407	Rasarfin		Others , Ras
	Rasarfin inhibits Ras and ARF6.		Others , Ras
T2026	CYM5442		S1P Receptor , LPL Receptor
	CYM5442 is an S1P agonist, targeting to Sphingosine.		S1P Receptor , LPL Receptor
TP1923L1	ELA-14(human) acetate	ELA-14(human) acetate (1886973-05-2 free base)	Apelin receptor , Arrestin
	ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.		Apelin receptor , Arrestin
T7026L	Kukoamine B mesylate		Antioxidant
	Kukoamine B mesylate is a novel cationic alkaloid derived from dermatophytes with antioxidant activity, inhibits LPS internalization in Kupffer and RAW 264.7 cells, and can be used to study acute inflammation and diabete...		Antioxidant
T12269	NUCC-390		CXCR
	NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compound facilitates nerve functional recovery following neurodeg...		CXCR
TP1944L1	Pep2-SVKI acetate	pep2-SVKI acetate(328944-75-8 free base)	GluR
	Pep2-SVKI acetate(pep2-SVKI acetate (328944-75-8 free base)) is a synthetic peptide salt that prevents internalization of AMPA-type glutamate receptor.		GluR
T77149	Cobolimab	TSR-022,GSK4069889	Others
	Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic mela...		Others
T10242	ACT-389949		Others
	ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of...		Others
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T4031	S1p receptor agonist 1	S1p-receptor-agonist-1	S1P Receptor , LPL Receptor
	S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.		S1P Receptor , LPL Receptor
T9169	MPP+ iodide		Mitochondrial Metabolism , Autophagy
	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...		Mitochondrial Metabolism , Autophagy
T13126	Tephrosin	Deguelinol I,Hydroxydeguelin	Others
	Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.		Others
TP1907	DynaMin inhibitory peptide, myristoylated
	Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
TP1840	Antennapedia Peptide
	Antennapedia Peptide is a 16 amino acid peptide corresponding to the region within the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization.
TN5580	Rediocide A
	Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediate...
T73665	Bufrolin
	Bufrolin, an analog of Cromoglycate (histamine release inhibitor) and a potent agonist of GPR35, enhances the interaction between β-arrestin-2 and both human GPR35a and rat GPR35. It stabilizes mast cells, exhibiting ant...
T81449	PKC-ε translocation inhibitor peptide		PKC
	PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαR trafficking [1].		PKC
T82596	Deac-SS-Biotin
	Deac-SS-Biotin is a potent antitumor compound that enters cells via biotin-mediated internalization. When combined with DTT (Glutathione mimetic), it effectively inhibits microtubule assembly and exhibits enhanced antitu...
T36634	ZQ 16
	Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK...
T76375	Targefrin
	Targefrin is a potent antagonist targeting EphA2, exhibiting a dissociation constant of 21 nM and an IC50 value of 10.8 nM for the EphA2-LBD. It promotes receptor internalization and degradation across multiple pancreati...