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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9499 | Icenticaftor | QBW251 | CFTR |
Icenticaftor (QBW251) is an orally active potentiator of CFTR channel. | |||
T16681 | Nesolicaftor | PTI-428 | CFTR , Autophagy |
Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis. | |||
T14935 | Elexacaftor | VX-445 | CFTR , Autophagy |
Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. | |||
T3135 | KM11060 | CFTR , Autophagy | |
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane. | |||
T1805 | Ataluren | PTC124 | CFTR , Autophagy |
Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde... | |||
T1634 | Glibenclamide | Glyburide | Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy |
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. | |||
T5312 | CFTR corrector 2 | FDL169 | CFTR , Autophagy |
CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation. | |||
T2451 | GlyH-101 | GlyH 101 | CFTR , Autophagy |
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. | |||
T1874 | PPQ-102 | PPQ102,CFTR Inhibitor,PPQ 102 | CFTR , Autophagy |
PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM). | |||
T2588 | Ivacaftor | Ivacaftor (VX-770),VX-770 | CFTR , Autophagy |
Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively. | |||
T4503 | Talniflumate | Somalgen | Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger |
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o... | |||
T7083 | GLPG1837 | ABBV-974 | CFTR , Autophagy |
GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. | |||
T10591 | BPO-27 racemate | BPO-27 (racemate) | CFTR , Autophagy |
BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM. | |||
T2486 | IOWH-032 | IOWH032,IOWH 032 | CFTR , Autophagy |
IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea. | |||
T2595 | Lumacaftor | VX-809,VRT 826809 | CFTR , Autophagy |
Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM). | |||
T6540 | Ibuprofen Lysine | Neoprofen | COX |
Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug. | |||
T1394 | Ibuprofen | Brufen,(±)-Ibuprofe,Motrin,Advil | COX |
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu... | |||
T2355 | CFTR(inh)-172 | CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172 | CFTR , Autophagy |
CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor. | |||
T15543 | IA-Alkyne | N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne | TRP/TRPV Channel |
IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of r... | |||
T2263 | Tezacaftor | VX661 | CFTR , Autophagy |
Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function. | |||
T131553 | Echinocystic acid (Albizziagenin) | ||
Echinocystic acid (Albizziagenin) is a useful organic compound for research related to life sciences and the catalog number is T131553. | |||
T20341 | DNDS | CFTR | |
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR). | |||
T29041 | UCCF-853 | UCCF853,UCCF 853 | CFTR |
UCCF-853 is a small-molecule CFTR modulator that can be used to study cystic fibrosis. | |||
T63806 | CFTR corrector 8 | CFTR | |
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic... | |||
T26955 | Cavosonstat | N91115,N 91115,N-91115 | GSNOR , CFTR |
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ... | |||
T60653 | CFTR corrector 9 | CFTR | |
CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1]. | |||
T10776 | CFTR corrector 4 | CFTR | |
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a... | |||
T31014 | Corrector C4 | Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a | Others |
Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis. | |||
T29114 | VRT-532 | CFpot-532,CFpot-532) | CFTR |
VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glyc... | |||
T30293 | Bamocaftor | VX-659 | CFTR |
Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c... | |||
T77604 | WAY-326766 | CFTR | |
WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF). | |||
T25376 | Ensifentrine | Ensifentrina,Ensifentrinum | PDE |
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and... | |||
T37744 | N-octanoyl-L-Homoserine lactone | C8-HSL,N-octanoyl-L-Homoserine lactone,OHL | Antibacterial |
N-octanoyl-L-Homoserine lactone (C8-HSL) is a diffusible exogenous Yersinia pestis population-sensing molecule that modulates LcrV virulence factors, controls gene expression by participating in population sensing, and a... | |||
T111959 | IFB-088 acetate | ||
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... | |||
T27098 | Ivacaftor-D9 | deutivacaftor,CTP-656 | |
CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis. | |||
T27734 | KM-003 (sulfite) | KM 003,P-552,KM003,P552,P 552,KM-003 | |
KM-003, a sodium channel blocker, is used potentially for the treatment of cystic fibrosis. | |||
T22252 | Galicaftor | Others | |
ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF). | |||
T13742 | Ivacaftor benzenesulfonate | VX-770 benzenesulfonate | Others |
Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator. | |||
T13704 | GLPG-3221 | Others | |
GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. | |||
T25136 | Aztreonam lysine | Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate | |
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF). | |||
T29040 | UCCF-029 | UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029 | |
UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR). | |||
T13705 | GLPG2451 | Cysteine Protease | |
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM). | |||
T23648 | AF-2785 | ||
In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels. | |||
T36519 | Posenacaftor sodium | ||
Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1]. | |||
T27146 | Denufosol tetrasodium | INS37217,INS 37217,INS-37217 | |
Denufosol is a P2Y2 agonist potentially for the treatment of cystic fibrosis. | |||
T13742L | Ivacaftor hydrate | VX-770 hydrate | Others |
Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment. | |||
T74748 | Zatonacaftor | ||
Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2]. | |||
T39633 | Navocaftor | GLPG 3067,ABBV-3067 | |
Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1). | |||
T74417 | Vanzacaftor | ||
Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator researched for cystic fibrosis treatment. | |||
T25898 | Olacaftor | VX 440,VX-440,VX440 | |
Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2866 | Echinocystic acid | Apoptosis , Antioxidant , Reactive Oxygen Species | |
Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant effects. | |||
T41139 | Echinocystic acid 28-O-β-D-glucoside | ||
Echinocystic acid 28-O-β-D-glucoside is a metabolite resulting from the microbial oxidation and glucosidation of Echinocystic acid. It exhibits inhibitory activity towards the tissue factor pathway, with an IC50 value me... | |||
T2532 | Tauroursodeoxycholate | Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA | Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite |
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode... | |||
T11124 | Duramycin | Lancovutide,Moli1901 | Others |
Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03855 | DNase I Protein, Human, Recombinant (His) | Human | HEK293 |
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phos... | |||
TMPY-01694 | Clusterin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-01691 | Clusterin Protein, Human, Recombinant (CLU34, His) | Human | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-00915 | Serpin A1 Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit... | |||
TMPJ-01350 | XPNPEP3 Protein, Human, Recombinant (His) | Human | E. coli |
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of an... | |||
TMPY-04633 | Frizzled 2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
FZD2 may be a tumor suppressor gene in salivary adenoid cystic carcinomas (SACCs) that inhibits cell growth and migration. OMOD2 is a rare skeletal dysplasia and characterized by facial dysmorphism and shortness of the u... | |||
TMPY-03629 | Syntaxin 8 Protein, Human, Recombinant (His) | Human | HEK293 |
STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated... | |||
TMPY-02769 | RNASET2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular r... | |||
TMPJ-00991 | S100A8 Protein, Rat, Recombinant (His) | Rat | E. coli |
Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytop... | |||
TMPY-04997 | Prostasin/PRSS8 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from hu... | |||
TMPY-00905 | Prostasin/PRSS8 Protein, Human, Recombinant (His) | Human | HEK293 |
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from hu... | |||
TMPY-02783 | Prostasin/PRSS8 Protein, Mouse, Recombinant (aa 30-289, His) | Mouse | Baculovirus-Insect Cells |
Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from hu... | |||
TMPY-06908 | Clusterin Protein, Human, Recombinant (sCLU, His) | Human | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPJ-00077 | IL -17C Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. Thes... | |||
TMPY-06211 | Clusterin Protein, Chinese hamster, Recombinant (His) | Chinese hamster | CHO |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPJ-00078 | IL-17C Protein, Human, Recombinant (His) | Human | Human Cells |
Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. Thes... | |||
TMPY-01634 | Surfactant protein D/SFTPD Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and c... | |||
TMPY-01765 | Surfactant protein D/SFTPD Protein, Human, Recombinant (His) | Human | HEK293 |
Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and c... | |||
TMPY-01110 | Surfactant protein D/SFTPD Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and c... | |||
TMPJ-01208 | IL-17RE Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Interleukin 17 Receptor E (IL 17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL 17 receptors. IL 17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma ... | |||
TMPJ-01230 | IL-17RE Protein, Human, Recombinant (hFc) | Human | Human Cells |
Interleukin 17 Receptor E (IL 17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL 17 receptors. IL 17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma ... | |||
TMPY-00442 | Serpin A1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit... |