magl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9967	MAGL-IN-5		Lipid
	MAGL-IN-5 is a non-selective lipase inhibitor.		Lipid
T9687	MAGL-IN-4	His121 ARG57	Lipase
	MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.		Lipase
T11939	MAGL-IN-1		Lipase
	MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.		Lipase
T81879	MAGL-IN-8		MAGL
	MAGL-IN-8 (compound 13) serves as a reversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting an inhibitory concentration half-maximal (IC50) value of 2.5 ± 0.4 nM for human MAGL (hMAGL) [1].		MAGL
T81880	MAGL-IN-11		MAGL
	MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and antioxidants [1].		MAGL
T61707	FAAH/MAGL-IN-2
	FAAH/MAGL-IN-2, a potent and reversible inhibitor of FAAH and MAGL, demonstrates oral activity and the ability to cross the blood-brain barrier. It exhibits IC50 values of 11 nM for FAAH and 36 nM for MAGL (Ki values of ...
T62489	MAGL-IN-6
	MAGL-IN-6 is a potent inhibitor of MAGL (IC50: 4.71 nM). MAGL-IN-6 can be used to study neurological diseases.
T81878	MAGL-IN-9		MAGL
	MAGL-IN-9, also referred to as compound 16, is a reversible inhibitor of monoacylglycerol lipase (MAGL) with a potent IC50 value of 2.7 nM [1].		MAGL
T81881	MAGL-IN-10		MAGL
	MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity. It is applicable in the study of cancer, neurological disorders, and inflammatory pathologie...		MAGL
T62671	FAAH/MAGL-IN-3
	FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) that acts on FAAH (IC50: 179 nM) and MAGL (IC50: 759 nM). FAAH/MAGL-IN-3 showed littl...
T61198	FAAH/MAGL-IN-1
	FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, res...
T5737	Euphol		Others , Lipase , Endogenous Metabolite
	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.		Others , Lipase , Endogenous Metabolite
T15614	JJKK 048		Lipase
	JJKK 048 is a potent and selective MAGL inhibitor.		Lipase
T15635	JZP-430		Lipase , MAGL
	JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL...		Lipase , MAGL
T8974	ML-211		Others
	ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)		Others
T5353	ABX-1431	Elcubragistat	Lipase
	ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).		Lipase
T15632	JW 642		Lipase
	JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).		Lipase
T17260	WWL70		Lipase , MAGL
	WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).		Lipase , MAGL
T4052	KML29		Lipase
	KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effective...		Lipase
T6554	JZL 184	JZL184	Lipase
	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.		Lipase