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Search Result

Search Results for " magl "

Targets

MAGL Lipid

43

Compounds

3

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9967 MAGL-IN-5 Lipid
MAGL-IN-5 is a non-selective lipase inhibitor.
T9687 MAGL-IN-4 His121 ARG57 Lipase
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
T11939 MAGL-IN-1 Lipase
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.
T81879 MAGL-IN-8 MAGL
MAGL-IN-8 (compound 13) serves as a reversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting an inhibitory concentration half-maximal (IC50) value of 2.5 ± 0.4 nM for human MAGL (hMAGL) [1].
T81880 MAGL-IN-11 MAGL
MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and antioxidants [1].
T61707 FAAH/MAGL-IN-2
FAAH/MAGL-IN-2, a potent and reversible inhibitor of FAAH and MAGL, demonstrates oral activity and the ability to cross the blood-brain barrier. It exhibits IC50 values of 11 nM for FAAH and 36 nM for MAGL (Ki values of ...
T62489 MAGL-IN-6
MAGL-IN-6 is a potent inhibitor of MAGL (IC50: 4.71 nM). MAGL-IN-6 can be used to study neurological diseases.
T81878 MAGL-IN-9 MAGL
MAGL-IN-9, also referred to as compound 16, is a reversible inhibitor of monoacylglycerol lipase (MAGL) with a potent IC50 value of 2.7 nM [1].
T81881 MAGL-IN-10 MAGL
MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity. It is applicable in the study of cancer, neurological disorders, and inflammatory pathologie...
T62671 FAAH/MAGL-IN-3
FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) that acts on FAAH (IC50: 179 nM) and MAGL (IC50: 759 nM). FAAH/MAGL-IN-3 showed littl...
T61198 FAAH/MAGL-IN-1
FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, res...
T15614 JJKK 048 Lipase
JJKK 048 is a potent and selective MAGL inhibitor.
T15635 JZP-430 Lipase , MAGL
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL...
T8974 ML-211 Others
ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)
T5353 ABX-1431 Elcubragistat Lipase
ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T15632 JW 642 Lipase
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).
T17260 WWL70 Lipase , MAGL
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
T4052 KML29 Lipase
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effective...
T6554 JZL 184 JZL184 Lipase
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T5815 MJN110 Cravatt Reagent Lipase
MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.
T2338 JZL195 FAAH , Lipase , Autophagy
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T8994 ML-​226 ML226,ML-226 MAGL
ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ.
T9374 AA38-3 1-Piperidinecarboxylic acid, 4-nitrophenyl ester FAAH , Lipase , MAGL
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
T61972 Pomaglumetad methionil hydrochloride LY2140023 hydrochloride GluR
Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hy...
T19850 Semaglutide Glucagon Receptor
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor).
T19850L Semaglutide Acetate Semaglutide Acetate(910463-68-2 Free base) Glucagon Receptor
Semaglutide Acetate is an agonist of a glucagon-like peptide 1 (GLP-1) receptor and can be used in studies about the treatment of type 2 diabetes.
T62937 MAGLi 432
MAGLi 432 is a potent, highly selective, non-covalent, reversible (MAGL) inhibitor that binds with high affinity to the MAGL active site, with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme), MAGLi 432 can...
T80879 Vamagloxistat
Vamagloxistat is a glycolate oxidase inhibitor utilized to mitigate hyperoxaluria and reduce the formation of kidney stones [1].
T11907 Pomaglumetad methionil anhydrous LY2140023 GluR
LY2140023 has the potential for schizophrenia.LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist.
T12520 Pomaglumetad methionil LY2140023 hydrate GluR
Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T12878 Semaglutide TFA (910463-68-2 free base) Semaglutide TFA Glucagon Receptor
Semaglutide TFA is a agonist of glucagon-like peptide-1 (GLP-1) receptor,with a potential for type 2 diabetes treatment.
T69191 Pemaglitazar
Pemaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist, with hypoglycemic activity.
T27703 JZP-361 JZP361,JZP 361 Lipase
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in ...
T11724 JNJ-42226314 Lipase
JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic ...
T16496 PF-06795071 Lipase
PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).
T24758 SAR127303 SAR-127303,SAR 127303
SAR127303 is an effective covalent inhibitor of MAGL. SAR127303 behaves as a selective and competitive inhibitor of mouse and human MAGL.
T37374 URB754
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mo...
T28235 OMDM169 OMDM 169,OMDM-169
OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM<IC(50)<0.41 microM tow...
T21905 N-Arachidonyl Maleimide
N-Arachidonyl maleimide is a potent, irreversible monoacylglycerol lipase (MAGL) inhibitor with an IC 50 value of 140 nM [1].
T36498 CAY10762 CAY10762
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg...
T37629 IDFP
The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors,...
T73317 JZP-MA-13
JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor, demonstrating impressive specificity with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty ac...
T12826 SA57 FAAH
SA57 is a potent, selective inhibitor of FAAH(IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH).

Compounds

MAGL-IN-5
T9967
Synonym:
Target: Lipid
MAGL-IN-4
T9687
Synonym: His121 ARG57
Target: Lipase
MAGL-IN-1
T11939
Synonym:
Target: Lipase
MAGL-IN-8
T81879
Synonym:
Target: MAGL
MAGL-IN-11
T81880
Synonym:
Target: MAGL
FAAH/MAGL-IN-2
T61707
Synonym:
Target:
MAGL-IN-6
T62489
Synonym:
Target:
MAGL-IN-9
T81878
Synonym:
Target: MAGL
MAGL-IN-10
T81881
Synonym:
Target: MAGL
FAAH/MAGL-IN-3
T62671
Synonym:
Target:
FAAH/MAGL-IN-1
T61198
Synonym:
Target:
JJKK 048
T15614
Synonym:
Target: Lipase
JZP-430
T15635
Synonym:
Target: Lipase, MAGL
ML-211
T8974
Synonym:
Target: Others
ABX-1431
T5353
Synonym: Elcubragistat
Target: Lipase
JW 642
T15632
Synonym:
Target: Lipase
WWL70
T17260
Synonym:
Target: Lipase, MAGL
KML29
T4052
Synonym:
Target: Lipase
JZL 184
T6554
Synonym: JZL184
Target: Lipase
MJN110
T5815
Synonym: Cravatt Reagent
Target: Lipase
JZL195
T2338
Synonym:
Target: FAAH, Lipase, Autophagy
ML-​226
T8994
Synonym: ML226,ML-226
Target: MAGL
AA38-3
T9374
Synonym: 1-Piperidinecarboxylic acid, 4-nitrophenyl ester
Target: FAAH, Lipase, MAGL
Pomaglumetad methionil hydrochloride
T61972
Synonym: LY2140023 hydrochloride
Target: GluR
Semaglutide
T19850
Synonym:
Target: Glucagon Receptor
Semaglutide Acetate
T19850L
Synonym: Semaglutide Acetate(910463-68-2 Free base)
Target: Glucagon Receptor
MAGLi 432
T62937
Synonym:
Target:
Vamagloxistat
T80879
Synonym:
Target:
Pomaglumetad methionil anhydrous
T11907
Synonym: LY2140023
Target: GluR
Pomaglumetad methionil
T12520
Synonym: LY2140023 hydrate
Target: GluR
Semaglutide TFA (910463-68-2 free base)
T12878
Synonym: Semaglutide TFA
Target: Glucagon Receptor
Pemaglitazar
T69191
Synonym:
Target:
JZP-361
T27703
Synonym: JZP361,JZP 361
Target: Lipase
JNJ-42226314
T11724
Synonym:
Target: Lipase
PF-06795071
T16496
Synonym:
Target: Lipase
SAR127303
T24758
Synonym: SAR-127303,SAR 127303
Target:
URB754
T37374
Synonym:
Target:
OMDM169
T28235
Synonym: OMDM 169,OMDM-169
Target:
N-Arachidonyl Maleimide
T21905
Synonym:
Target:
CAY10762
T36498
Synonym: CAY10762
Target:
IDFP
T37629
Synonym:
Target:
JZP-MA-13
T73317
Synonym:
Target:
SA57
T12826
Synonym:
Target: FAAH
Cat No. Product Name Synonyms Targets
T5737 Euphol Others , Lipase , Endogenous Metabolite
Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
TN5409 Maglifloenone Denudatone
Maglifloenone is a natural product of Magnolia, Magnoliaceae. The catalog number is TN5409 and the CAS number is 82427-77-8. Maglifloenone can be used as a reference standard.
TN4904 Rehmaglutin D Others
Rehmaglutin D is a natural product of Ailanthus, Simaroubaceae. The catalog number is TN4904 and the CAS number is 103744-84-9. Rehmaglutin D can be used as a reference standard.

Natural Products

euphol
T5737
Synonym:
Target: Others, Lipase, Endogenous Metabolite
Maglifloenone
TN5409
Synonym: Denudatone
Target:
Rehmaglutin D
TN4904
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (2)
Expression System：
E. coli (1)
HEK293 (1)
Tag：
N-terminal GST-tagged (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-00025 Mammaglobin B/SCGB2A1 Protein, Human, Recombinant (hFc) Human HEK293
SCGB2A1 represented a novel, prognostic factor for CRC, and that expression of SCGB2A1 correlated with chemoresistance, radioresistance and cancer cell stemness. SCGB2A1 is a top differentially expressed gene in all majo...
TMPH-01637 Mammaglobin-A/SCGB2A2 Protein, Human, Recombinant (GST) Human E. coli
Mammaglobin-A/SCGB2A2 Protein, Human, Recombinant (GST) is expressed in E. coli.
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