Diabete

Pioglitazone (U 72107) is a PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively, and has selective and oral activity. Pioglitazone can be used in diabetes research.

Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2D).

Sucrose (D-(+)-Saccharose) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons.

Trelagliptin (SYR-472) is a highly specific, long-acting DPP-4 inhibitor.

SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.

GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis.

WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

Butyl isobutyl phthalate (ButylIsobutylPhthalate) is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect

Sequoyitol (5-O-Methyl-Myo-Inositol), a methyl derivative of inositol, is often used to treat diabetes.

Emodin (Frangula emodin) is an 11β-HSD1 inhibitor with a selective IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice, respectively. Emodin has antiviral, anti-inflammatory, and anti-cancer effects. Emodin can improve metabolic disorders in diet-induced obese mice.

Vitamin D3 (Cholecalciferol) is a naturally occurring form of vitamin D that, after metabolic activation, can induce cell differentiation and cancer cell proliferation. It can also be used to establish kidney stone models.

Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells and inhibits synthesis of glucose by the liver. Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.

Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.

KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2 Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 for the treatment of diabete.

Sheng Gelieting (CGT-8012) is an inhibitor of the dipeptidyl peptidase-IV enzyme (DP-IV) with an IC50 value of 87 nM. It can be utilized for research into the dipeptidyl peptidase-IV enzyme, including studies on diabetes, particularly type II diabetes.

SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase ( LMW-PTP ) inhibitor ( IC 50 =4 nM, K i =1.2 nM). SPAA-52 can be used in diabete research [1] .

DMG-PEG2000 (DMG-PEG2000) can be used for the preparation of lipid nanoparticles for oral delivery of plasmid DNA in vivo to improve the mucus permeability and delivery efficiency of nanoparticles. DMG-PEG 2000 can be used for the preparation of siRNA transfected liposomes, which can improve the transfection efficiency.