cd28 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3189	B7/CD28 interaction inhibitor 1	CTLA-4 inhibitor	Others
	B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.		Others
T78255	Anti-Mouse CD28 Antibody (37.51)
	Anti-Mouse CD28 Antibody is a Syrian Hamster-derived IgG inhibitor targeting mouse CD28.
T10722	CD80-IN-3		Bombesin Receptor
	CD80-IN-3 is a potent CD80 inhibitor and inhibits CD80/CD28 interaction (Kd: 125 nM; EC50: 630 nM).		Bombesin Receptor
T8924	MFCD28987368		Others
	MFCD28987368 is a degradable ADC linker that can be used in the synthesis of antibody coupled drugs (ADCs).		Others
T78274	Omburtamab
	Omburtamab, an anti-CD276 (also known as B7-H3) monoclonal antibody, targets the B7/CD28 family protein CD276, prevalent in solid human tumors. This binding capability positions omburtamab as a potential research tool in...
T77093	Theralizumab	TGN1412,TAB-08,TABO8	Others
	Theralizumab (TGN1412) is an anti-CD28-targeting monoclonal antibody that directly stimulates T cells. Theralizumab has antitumor activity and is used for the treatment of B-cell chronic lymphocytic leukemia and rheumato...		Others
TN1110	Shanziside	Shanzhiside	IL Receptor
	Shanziside (Shanzhiside) has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood...		IL Receptor
T63790	Cbl-b-IN-3		E1/E2/E3 Enzyme
	Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b n...		E1/E2/E3 Enzyme
T76817	Lulizumab
	Lulizumab, a humanized anti-CD28 recombinant antibody, functions as a selective CD28 blockade. By specifically targeting CD28 signaling, it inhibits T cell activation [1].
T26367	Reltecimod	NSC-37096,P2TA,AB-103,AB103,P-2TA
	Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.
T26367L	Reltecimod sodium	AB 103 sodium,AB-103 sodium,AB103 sodium
	Reltecimod sodium, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.
T72858	Maydispenoid B
	Maydispenoid B, a potent immunosuppressor, effectively inhibits the proliferation of murine splenocytes activated by anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide.
T78107	Reltecimod TFA	AB-103 TFA
	Reltecimod (AB-103) TFA is an antagonist of the T-cell-specific surface glycoprotein CD28 (TP44), demonstrating efficacy against various bacterial infections, including their exotoxins and endotoxins, as well as ionizing...
T72857	Maydispenoid A
	Maydispenoid A, a potent immunosuppressive compound, effectively inhibits murine splenocyte proliferation activated by both anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide.
T77074	Lulizumab pegol
	Lulizumab pegol (BMS-931699) is an antagonist anti-CD28 antibody that effectively inhibits T-cell proliferation, making it a potential therapeutic agent for kidney transplantation and autoimmunity disease research [1].
T79791	Immunosuppressant-1		Apoptosis
	Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce...		Apoptosis
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine recept...