β-lactamase

β-LactaMase is a bacterially produced enzyme that hydrolyzes antibiotics such as penicillins, and its activity is inhibited by ethylenediaminetetraacetic acid (EDTA).

Meropenem (SM 7338) is a broad-spectrum carbapenem antibiotic administered intravenously for severe bacterial infections caused by sensitive agents. It commonly causes mild, transient aminotransferase elevations and can rarely lead to clinically apparent cholestatic liver injury.

Ampicillin Trihydrate (NCI-C56086), a broad-spectrum semisynthetic derivative of aminopenicillin, is a β-lactam antibiotic.

Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.

Asparenomycin C is a carbapenem antibiotic known for its potent β-lactamase inhibitory activity.

Asparenomycin B is a carbapenem antibiotic (antibiotic) known for its potent β-lactamase inhibitory activity.

Asparenomycin A is a carbapenem-class antibiotic known for its potent β-lactamase inhibitory activity.

Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in human chronic myelogenous leukemia cancer cells.