β-lactamase

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) is a β-Lactamase inhibitor and targets the infection of Neisseria gonorrhoeae.

β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.

Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.

Durlobactam sodium salt (ETX2514) is a beta-lactamase inhibitor with IC50 values of 4 nM, 14 nM and 190 nM against class A KPC-2, class C AmpC and class D OXA-24.

Zidebactam (WCK-5107) is a β-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor (IC50 = 0.26 μg/ml), with enzymatic inhibitory activity, and can be used for antibacterial research.

Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.

Vaborbactam ammonium salt is a β-lactamase inhibitor that restores carbapenem activity against KPC-producing strains and is often used in conjunction with other drugs to study fungal infections.

(3R,6R)-Vaborbactam ((3R,6R)-Vaborbactam (Iso-1360457-46-0)) is a cyclic boronic acid pharmacophore β-lactamase inhibitor with potential antimicrobial activity. (S)-Vamicamide ((S)-Vamicamide (Iso-132373-81-0)) is a novel anticholinergic compound.

Durlobactam Triethylamine (ETX2514 Triethylamine) is a diazabicyclooctane β-lactamase inhibitor that inhibits classes A, C, and D β-lactams.Durlobactam Triethylamine has antifungal infection activity.

(rac)-Xeruborbactam ammonium is a beta-lactamase inhibitor and can be used in the study of bacterial infections.

Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.

Ampicillin Trihydrate (NCI-C56086), a broad-spectrum semisynthetic derivative of aminopenicillin, is a β-lactam antibiotic.

Aztreonam (SQ-26,776), a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum, possesses bactericidal activity.

(CL227193) )binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Piperacillin Sodium is the sodium salt of piperacillin, a broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic with bactericidal activity. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic with bactericidal activity. Cefuroxime sodium (Cefuroxime sodium salt) inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.

Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.

Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.

Avibactam sodium (NXL-104) is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8/80/38 nM) covalently and reversibly. Avibactam sodium has antimicrobial activity and can be used to treat urinary tract infections.

Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM).

Ampicillin sodium (Domicillin) is a broad-spectrum β -lactam antibiotic. Ampicillin sodium combates a variety of Gram-positive and Gram-negative bacteria.

Mezlocillin Sodium (Baycipen) is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.

Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor.

Piperacillin (Pipercillin) is a semisynthetic penicillin with wide spectrum of antimicrobial activity(particularly pseudomonas strains)