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p38 MAPK

p38 MAPKs (α, β, γ, and δ) are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/6, the p38 MAPK kinases. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1.
Cat. No. Product name CAS No. Purity Chemical Structure
T68134 Ro-3201195 249937-52-8 98%
Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.
T36010 P38 MAPK Inhibitor 219138-24-6 98%
p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.
T41142 EM 163 1206480-93-4 98%
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR stru...
T27627 Iroxanadine 203805-20-3 98%
Iroxanadine is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pu...
T68139 Scio-323 309913-51-7 98%
Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
T38665 OVA-E1 peptide TFA 1262750-80-0 98%
OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.
TN3404 Altholactone 65408-91-5 98%
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN4394 Kobophenol A 124027-58-3 98%
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN3042 4-Hydroxycinnamamide 194940-15-3 98%
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN4938 Samidin 477-33-8 98%
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN4317 Isopedicin 4431-42-9 98%
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN5011 Shizukaol B 142279-40-1 98%
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T7162 R1487 Hydrochloride 449808-64-4 98%
R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
T10298 AMG-548 hydrochloride (864249-60-5 free base) T10298 98%
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective a...
TN4774 Physalin A 23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1751 Hydroxycitric acid 6205-14-7 98%
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
TN1347 8-Prenylkaempferol 28610-31-3 98%
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN4986 Selinidin 19427-82-8 98%
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
TN5174 Trichosanatine 169626-16-8 98%
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TMA1743 Ergosterol peroxide 2061-64-5 98%
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
Ro-3201195
T68134
Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.
p38 MAPK Inhibitor
T36010
p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.
EM 163
T41142
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR stru...
Iroxanadine
T27627
Iroxanadine is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pu...
Scio-323
T68139
Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
OVA-E1 peptide TFA
T38665
OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
4-Hydroxycinnamamide
TN3042
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
Samidin
TN4938
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Isopedicin
TN4317
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
Shizukaol B
TN5011
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
R1487 Hydrochloride
T7162
R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
AMG-548 hydrochloride (864249-60-5 free base)
T10298
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective a...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Hydroxycitric acid
TN1751
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
8-Prenylkaempferol
TN1347
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
Selinidin
TN4986
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
Trichosanatine
TN5174
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
Ergosterol peroxide
TMA1743
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
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