Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor. |
SB-431542 is a potent and selective inhibitor of ALK5 (IC50: 94 nM) and is also an inhibitor of ALK4 (IC50: 140 nM) and ALK7. |
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM). |
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities. |
LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) vers...
K02288 is a novel small molecule inhibitor of ALK1/2/3/6. |
LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6)...
CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. |
DMH-1 is a potent and selective BMP inhibitor. |
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. |
LDN-214117 is a potent and selective ALK2 inhibitor. |
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posi...
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. |
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM). |
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay). |
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5. |
CEP-28122 is a highly potent and selective orally active ALK inhibitor. |
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability. |
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). |
||ALK5 Inhibitor IV
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12...
||ALK inhibitor 2
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. |
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. ...
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wi...
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to...
Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplasti...
Brigatinib is a highly potent and selective ALK inhibitor. |
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and ...
HG-14-10-04 is a potent and specific ALK inhibitor. |
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively. |
LDN193189 hydrochloride is a selective BMP type I receptor kinases inhibitor. |
RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor. |
Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as ac...
Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC. |
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM). |
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM). |
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). |
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. |
Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM) |
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM) |
Alectinib hydrochloride is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM) |
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK). |
||A 83-01 sodium salt
A 83-01 sodium salt is a potent inhibitor of ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50s: 12, 45 and 7.5 nM against th...
ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3. |
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM). |
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor (IC50: 18 nM; Kd: 2.9 nM) with inhibitory to mammary tumor growth. AZ12601011 inhibits phospho...
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect....
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM). |
IN-1130 is a highly selective inhibitor of transforming growth factor-β type I receptor kinase (ALK5) (IC50: 5.3 nM for ALK5-mediated Smad3 phosphorylation). I...
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I recepto...
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM). |
||(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline hydrochloride hemihydrate is an agonist of muscarinic receptor. |
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, In...
Ensartinib (X-396) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutati...