ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat. No.	Product name	CAS No.	Purity
T13138	TGFBR1-IN-1	2170830-26-7	98%
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T61424	OD36 hydrochloride	2387510-88-3	98%
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
T15262	Vactosertib Hydrochloride	1352610-25-3	98%
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T10283	ALK-IN-5	2351929-66-1	98%
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T13781	MS4077	2230077-10-6	98%
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442	A 83-01 sodium salt	2828431-89-4	98%
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
T13421	(-)-Cevimeline hydrochloride hemihydrate	T13421	98%
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
T10426	AZ12601011	2748337-86-0	98%
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
T1791L	Ceritinib dihydrochloride	1380575-43-8	99.99%
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
T2251	NVP-TAE 684	761439-42-3	99.91%
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T8152	6-Demethoxytangeretin	6601-66-7	99.89%
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T4071	Repotrectinib	1802220-02-5	99.86%
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T4975	SM 16	614749-78-9	99.81%
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T2449	D4476	301836-43-1	99.8%
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T35348	LDN-193189 2HCl	1435934-00-1	99.78%
LDN-193189 2HCl is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively,...
T16708	R-268712	879487-87-3	99.77%
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
T1943	ML347	1062368-49-3	99.71%
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T1942	DMH-1	1206711-16-1	99.7%
DMH-1 is a potent and selective BMP inhibitor.
T8399	Crizotinib hydrochloride	1415560-69-8	99.67%
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T3079	GSK1838705A	1116235-97-2	99.63%
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T13138

TGFBR1-IN-1

2170830-26-7

98%

TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).

T61424

OD36 hydrochloride

2387510-88-3

98%

OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...

T15262

Vactosertib Hydrochloride

1352610-25-3

98%

Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...

T10283

ALK-IN-5

2351929-66-1

98%

ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).

T13781

MS4077

2230077-10-6

98%

MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).

T10442

A 83-01 sodium salt

2828431-89-4

98%

A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...

T13421

(-)-Cevimeline hydrochloride hemihydrate

T13421

98%

(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...

T10426

AZ12601011

2748337-86-0

98%

AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...

T1791L

Ceritinib dihydrochloride

1380575-43-8

99.99%

Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...

T2251

NVP-TAE 684

761439-42-3

99.91%

NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).

T8152

6-Demethoxytangeretin

6601-66-7

99.89%

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.

T4071

Repotrectinib

1802220-02-5

99.86%

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.

T4975

SM 16

614749-78-9

99.81%

SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).

T2449

D4476

301836-43-1

99.8%

D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).

T35348

LDN-193189 2HCl

1435934-00-1

99.78%

LDN-193189 2HCl is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively,...

T16708

R-268712

879487-87-3

99.77%

R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...

T1943

ML347

1062368-49-3

99.71%

ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.

T1942

DMH-1

1206711-16-1

99.7%

DMH-1 is a potent and selective BMP inhibitor.

T8399

Crizotinib hydrochloride

1415560-69-8

99.67%

Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)

T3079

GSK1838705A

1116235-97-2

99.63%

GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...