ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.

Cat. No.	Product name	CAS No.	Purity
T10426	AZ12601011	2748337-86-0	98%
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC 50 of 18 nM and a K d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via se...
T13421	(-)-Cevimeline hydrochloride hemihydrate	T13421	98%
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
T10442	A 83-01 sodium salt	2828431-89-4	98%
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
T13781	MS4077	2230077-10-6	98%
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10283	ALK-IN-5	2351929-66-1	98%
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T15262	Vactosertib Hydrochloride	1352610-25-3	98%
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T13138	TGFBR1-IN-1	2170830-26-7	98%
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T63313	Unecritinib	1418026-92-2	98%
Unecritinib (TQ-B3101) is a potent, orally active, highly potent, blood-brain barrier permeable and low toxic inhibitor of EGFR tyrosine kinase with antitumor ac...
T2612	CEP-28122	1022958-60-6	98%
CEP-28122 is a highly potent and selective orally active ALK inhibitor.
T50042	5-phenylthieno[2,3-d]pyrimidin-4-amine	195193-10-3	98%
5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocyclic compound. It inhibits a variety of enzymes such as kinases and phosphodiesterases and has potential ther...
T2641	KRCA-0008	1472795-20-2	98%
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T13564	AZ7550	1421373-99-0	98%
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T11254	F-1	2244775-31-1	98%
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
T3059	ALK-IN-1	1197958-12-5	98%
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...
T15612	JH-VIII-157-02	1639422-97-1	98%
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...
T15572	IN-1130	868612-83-3	98%
IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein...
T9224	CH5424802 analog	1256577-71-5	98%
CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
T13416	ZX-29	2254805-62-2	98%
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
T4015	HG-14-10-04	1356962-34-9	98%
HG-14-10-04 is a potent and specific ALK inhibitor.
T10285	ALK inhibitor 1	761436-81-1	98%
ALK inhibitor 1 is a selective ALK kinase inhibitor.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T10426

AZ12601011

2748337-86-0

98%

AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC 50 of 18 nM and a K d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via se...

T13421

(-)-Cevimeline hydrochloride hemihydrate

T13421

98%

(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...

T10442

A 83-01 sodium salt

2828431-89-4

98%

A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...

T13781

MS4077

2230077-10-6

98%

MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).

T10283

ALK-IN-5

2351929-66-1

98%

ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).

T15262

Vactosertib Hydrochloride

1352610-25-3

98%

Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...

T13138

TGFBR1-IN-1

2170830-26-7

98%

TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).

T63313

Unecritinib

1418026-92-2

98%

Unecritinib (TQ-B3101) is a potent, orally active, highly potent, blood-brain barrier permeable and low toxic inhibitor of EGFR tyrosine kinase with antitumor ac...

T2612

CEP-28122

1022958-60-6

98%

CEP-28122 is a highly potent and selective orally active ALK inhibitor.

T50042

5-phenylthieno[2,3-d]pyrimidin-4-amine

195193-10-3

98%

5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocyclic compound. It inhibits a variety of enzymes such as kinases and phosphodiesterases and has potential ther...

T2641

KRCA-0008

1472795-20-2

98%

KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.

T13564

AZ7550

1421373-99-0

98%

AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

T11254

F-1

2244775-31-1

98%

F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...

T3059

ALK-IN-1

1197958-12-5

98%

AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...

T15612

JH-VIII-157-02

1639422-97-1

98%

JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...

T15572

IN-1130

868612-83-3

98%

IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein...

T9224

CH5424802 analog

1256577-71-5

98%

CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.

T13416

ZX-29

2254805-62-2

98%

ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...

T4015

HG-14-10-04

1356962-34-9

98%