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ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T61424 OD36 hydrochloride 2387510-88-3 99.85%
OD36 hydrochloride
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
T13138 TGFBR1-IN-1 2170830-26-7 98%
TGFBR1-IN-1
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T15262 Vactosertib Hydrochloride 1352610-25-3 98%
Vactosertib Hydrochloride
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T10283 ALK-IN-5 2351929-66-1 98%
ALK-IN-5
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T13781 MS4077 2230077-10-6 98%
MS4077
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442 A 83-01 sodium salt 2828431-89-4 98%
A 83-01 sodium salt
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
T13421 (-)-Cevimeline hydrochloride hemihydrate T13421 98%
(-)-Cevimeline hydrochloride hemihydrate
Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's ...
T10426 AZ12601011 2748337-86-0 98%
AZ12601011
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
T76858 Ascrinvacumab 1463459-96-2 SDS-PAGE:95% SEC-HPLC:98.18%
Ascrinvacumab
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ...
T1791L Ceritinib dihydrochloride 1380575-43-8 99.99%
Ceritinib dihydrochloride
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ...
T1936 Alectinib 1256580-46-7 99.97%
Alectinib
Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T3061 Lorlatinib 1454846-35-5 99.93%
Lorlatinib
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1...
T2251 NVP-TAE 684 761439-42-3 99.91%
NVP-TAE 684
NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T8152 6-Demethoxytangeretin 6601-66-7 99.89%
6-Demethoxytangeretin
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T1726 SB-431542 301836-41-9 99.87%
SB-431542
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other...
T4071 Repotrectinib 1802220-02-5 99.86%
Repotrectinib
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
T1944 LDN-214117 1627503-67-6 99.85%
LDN-214117
LDN-214117 is a potent and selective ALK2 inhibitor.
T4975 SM 16 614749-78-9 99.81%
SM 16
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T2449 D4476 301836-43-1 99.8%
D4476
D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T6496 Vactosertib 1352608-82-2 99.78%
Vactosertib
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn...
OD36 hydrochloride
T61424
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
TGFBR1-IN-1
T13138
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
Vactosertib Hydrochloride
T15262
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
ALK-IN-5
T10283
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
MS4077
T13781
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
A 83-01 sodium salt
T10442
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
(-)-Cevimeline hydrochloride hemihydrate
T13421
Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's ...
AZ12601011
T10426
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
Ascrinvacumab
T76858
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ...
Ceritinib dihydrochloride
T1791L
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ...
Alectinib
T1936
Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
Lorlatinib
T3061
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1...
NVP-TAE 684
T2251
NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).
6-Demethoxytangeretin
T8152
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
SB-431542
T1726
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other...
Repotrectinib
T4071
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
LDN-214117
T1944
LDN-214117 is a potent and selective ALK2 inhibitor.
SM 16
T4975
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
D4476
T2449
D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
Vactosertib
T6496
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn...
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