T13138 |
TGFBR1-IN-1
|
2170830-26-7
|
98%
|
|
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
|
T61424 |
OD36 hydrochloride
|
2387510-88-3
|
98%
|
|
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
|
T15262 |
Vactosertib Hydrochloride
|
1352610-25-3
|
98%
|
|
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
|
T10283 |
ALK-IN-5
|
2351929-66-1
|
98%
|
|
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
|
T13781 |
MS4077
|
2230077-10-6
|
98%
|
|
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
|
T10442 |
A 83-01 sodium salt
|
2828431-89-4
|
98%
|
|
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
|
T13421 |
(-)-Cevimeline hydrochloride hemihydrate
|
T13421
|
98%
|
|
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
|
T10426 |
AZ12601011
|
2748337-86-0
|
98%
|
|
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
|
T1791L |
Ceritinib dihydrochloride
|
1380575-43-8
|
99.99%
|
|
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
|
T2251 |
NVP-TAE 684
|
761439-42-3
|
99.91%
|
|
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
|
T8152 |
6-Demethoxytangeretin
|
6601-66-7
|
99.89%
|
|
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
|
T4071 |
Repotrectinib
|
1802220-02-5
|
99.86%
|
|
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
|
T4975 |
SM 16
|
614749-78-9
|
99.81%
|
|
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
|
T2449 |
D4476
|
301836-43-1
|
99.8%
|
|
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
|
T35348 |
LDN-193189 2HCl
|
1435934-00-1
|
99.78%
|
|
LDN-193189 2HCl is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively,...
|
T16708 |
R-268712
|
879487-87-3
|
99.77%
|
|
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
|
T1943 |
ML347
|
1062368-49-3
|
99.71%
|
|
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
|
T1942 |
DMH-1
|
1206711-16-1
|
99.7%
|
|
DMH-1 is a potent and selective BMP inhibitor.
|
T8399 |
Crizotinib hydrochloride
|
1415560-69-8
|
99.67%
|
|
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
|
T3079 |
GSK1838705A
|
1116235-97-2
|
99.63%
|
|
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
|