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ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
Cat. No. Product name CAS No. Purity Chemical Structure
T13138 TGFBR1-IN-1 2170830-26-7 98%
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T61424 OD36 hydrochloride 2387510-88-3 98%
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
T15262 Vactosertib Hydrochloride 1352610-25-3 98%
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T10283 ALK-IN-5 2351929-66-1 98%
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T13781 MS4077 2230077-10-6 98%
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442 A 83-01 sodium salt 2828431-89-4 98%
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
T13421 (-)-Cevimeline hydrochloride hemihydrate T13421 98%
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
T10426 AZ12601011 2748337-86-0 98%
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
T1791L Ceritinib dihydrochloride 1380575-43-8 99.99%
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
T2251 NVP-TAE 684 761439-42-3 99.91%
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T8152 6-Demethoxytangeretin 6601-66-7 99.89%
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T4071 Repotrectinib 1802220-02-5 99.86%
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T4975 SM 16 614749-78-9 99.81%
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T2449 D4476 301836-43-1 99.8%
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T35348 LDN-193189 2HCl 1435934-00-1 99.78%
LDN-193189 2HCl is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively,...
T16708 R-268712 879487-87-3 99.77%
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
T1943 ML347 1062368-49-3 99.71%
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T1942 DMH-1 1206711-16-1 99.7%
DMH-1 is a potent and selective BMP inhibitor.
T8399 Crizotinib hydrochloride 1415560-69-8 99.67%
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
T3079 GSK1838705A 1116235-97-2 99.63%
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
TGFBR1-IN-1
T13138
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
OD36 hydrochloride
T61424
OD36 hydrochloride is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of t...
Vactosertib Hydrochloride
T15262
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
ALK-IN-5
T10283
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
MS4077
T13781
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
A 83-01 sodium salt
T10442
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
(-)-Cevimeline hydrochloride hemihydrate
T13421
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
AZ12601011
T10426
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
Ceritinib dihydrochloride
T1791L
Ceritinib dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, Ins...
NVP-TAE 684
T2251
NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
6-Demethoxytangeretin
T8152
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
Repotrectinib
T4071
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
SM 16
T4975
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
D4476
T2449
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
LDN-193189 2HCl
T35348
LDN-193189 2HCl is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively,...
R-268712
T16708
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
ML347
T1943
ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
DMH-1
T1942
DMH-1 is a potent and selective BMP inhibitor.
Crizotinib hydrochloride
T8399
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
GSK1838705A
T3079
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
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