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ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
Cat. No. Product name CAS No. Purity Chemical Structure
T15262 Vactosertib Hydrochloride 1352610-25-3 98%
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T13781 MS4077 2230077-10-6 98%
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T15572 IN-1130 868612-83-3 98%
IN-1130 is a highly selective inhibitor of transforming growth factor-β type I receptor kinase (ALK5) (IC50: 5.3 nM for ALK5-mediated Smad3 phosphorylation). IN-...
T13421 (-)-Cevimeline hydrochloride hemihydrate T13421 98%
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrom...
T10283 ALK-IN-5 2351929-66-1 98%
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T10442 A 83-01 sodium salt T10442 98%
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the transcription ...
T10426 AZ12601011 T10426 98%
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC 50 of 18 nM and a K d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via se...
T10287 ALK2-IN-2 2254409-25-9 98%
ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
T13138 TGFBR1-IN-1 2170830-26-7 98%
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T15612 JH-VIII-157-02 1639422-97-1 98%
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...
T9837 N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline 1352608-94-6 98%
Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
T50042 5-phenylthieno[2,3-d]pyrimidin-4-amine 195193-10-3 95.00%
5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
T2641 KRCA-0008 1472795-20-2 96.19%
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T3059 ALK-IN-1 1197958-12-5 97.66%
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...
T11254 F-1 2244775-31-1 97.66%
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
T1962 ASP3026 1097917-15-1 98%
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit...
T1800 GW788388 452342-67-5 98%
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T3550 X-376 1365267-27-1 98.29%
Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic...
T9224 CH5424802 analog 1256577-71-5 98.31%
CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
T4015 HG-14-10-04 1356962-34-9 98.36%
HG-14-10-04 is a potent and specific ALK inhibitor.
Vactosertib Hydrochloride
T15262
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
MS4077
T13781
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
IN-1130
T15572
IN-1130 is a highly selective inhibitor of transforming growth factor-β type I receptor kinase (ALK5) (IC50: 5.3 nM for ALK5-mediated Smad3 phosphorylation). IN-...
(-)-Cevimeline hydrochloride hemihydrate
T13421
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrom...
ALK-IN-5
T10283
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
A 83-01 sodium salt
T10442
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the transcription ...
AZ12601011
T10426
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC 50 of 18 nM and a K d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via se...
ALK2-IN-2
T10287
ALK2-IN-2 is a potent and selective inhibitor of ALK2 (IC50: 9 nM), and over 700-fold selectivity against ALK3.
TGFBR1-IN-1
T13138
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
JH-VIII-157-02
T15612
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
T9837
Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.
5-phenylthieno[2,3-d]pyrimidin-4-amine
T50042
5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
KRCA-0008
T2641
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
ALK-IN-1
T3059
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...
F-1
T11254
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
ASP3026
T1962
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit...
GW788388
T1800
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
X-376
T3550
Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic...
CH5424802 analog
T9224
CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
HG-14-10-04
T4015
HG-14-10-04 is a potent and specific ALK inhibitor.
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