T10426 |
AZ12601011
|
2748337-86-0
|
98%
|
|
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC 50 of 18 nM and a K d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via se...
|
T13421 |
(-)-Cevimeline hydrochloride hemihydrate
|
T13421
|
98%
|
|
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
|
T10442 |
A 83-01 sodium salt
|
2828431-89-4
|
98%
|
|
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
|
T13781 |
MS4077
|
2230077-10-6
|
98%
|
|
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
|
T10283 |
ALK-IN-5
|
2351929-66-1
|
98%
|
|
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
|
T15262 |
Vactosertib Hydrochloride
|
1352610-25-3
|
98%
|
|
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
|
T13138 |
TGFBR1-IN-1
|
2170830-26-7
|
98%
|
|
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
|
T63313 |
Unecritinib
|
1418026-92-2
|
98%
|
|
Unecritinib (TQ-B3101) is a potent, orally active, highly potent, blood-brain barrier permeable and low toxic inhibitor of EGFR tyrosine kinase with antitumor ac...
|
T2612 |
CEP-28122
|
1022958-60-6
|
98%
|
|
CEP-28122 is a highly potent and selective orally active ALK inhibitor.
|
T50042 |
5-phenylthieno[2,3-d]pyrimidin-4-amine
|
195193-10-3
|
98%
|
|
5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocyclic compound. It inhibits a variety of enzymes such as kinases and phosphodiesterases and has potential ther...
|
T2641 |
KRCA-0008
|
1472795-20-2
|
98%
|
|
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
|
T13564 |
AZ7550
|
1421373-99-0
|
98%
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
T11254 |
F-1
|
2244775-31-1
|
98%
|
|
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
|
T3059 |
ALK-IN-1
|
1197958-12-5
|
98%
|
|
AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...
|
T15612 |
JH-VIII-157-02
|
1639422-97-1
|
98%
|
|
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-A...
|
T15572 |
IN-1130
|
868612-83-3
|
98%
|
|
IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein...
|
T9224 |
CH5424802 analog
|
1256577-71-5
|
98%
|
|
CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
|
T13416 |
ZX-29
|
2254805-62-2
|
98%
|
|
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces ...
|
T4015 |
HG-14-10-04
|
1356962-34-9
|
98%
|
|
HG-14-10-04 is a potent and specific ALK inhibitor.
|
T10285 |
ALK inhibitor 1
|
761436-81-1
|
98%
|
|
ALK inhibitor 1 is a selective ALK kinase inhibitor.
|