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Results for "

proliferator

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    168
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Peptide_Products
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    TargetMol | Dye_Reagents
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    TargetMol | Natural_Products
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    TargetMol | Inhibitors_Agonists
Pioglitazone
U 72107
T0214111025-46-8
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione indicated for the treatment of type 2 diabetes, and has been linked to rare instances of acute liver injury.
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TargetMol | Inhibitor Hot
Rosiglitazone
BRL49653
T0334122320-73-4
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
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TargetMol | Inhibitor Hot
5-Aminosalicylic Acid
Mesalazine, Mesalamine, 5-ASA
T064689-57-6
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
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TargetMol | Inhibitor Hot
GW9662
TIMTEC-BB SBB006523, GW 9662
T226022978-25-2
GW9662 (TIMTEC-BB SBB006523) is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα δ in cells.
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TargetMol | Inhibitor Hot
Troglitazone
Romozin, Romglizone, Rezulin, Prelay, Noscal, CS-045
T317097322-87-7
Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
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TargetMol | Inhibitor Hot
T0070907
T6689313516-66-4
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
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TargetMol | Inhibitor Hot
ERRα antagonist-1
ERR+ - antagonist-1, ERRa antagonist-1
T112301072145-33-5In house
ERRα antagonist-1 (ERR+ - antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, displaying IC50 values of 170 nM and 180 nM, respectively. Notably, ERRα antagonist-1 does not interfere with the interactions involving ERRβ or ERRγ and the PGC-1α and PGC-1β coactivators. Furthermore, it does not affect the interaction between either ERα or ERβ and PGC-1α or SRC-1.
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6-8 weeks
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Inolitazone
RS5444, Efatutazone, CS-7017
T15581223132-37-4In house
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
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8-10 weeks
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TargetMol | Inhibitor Sale
MCC-555
Netoglitazone, Isaglitazone
T21764161600-01-7In house
MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.
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Darglitazone
CP-86325
T22708141200-24-0In house
Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.
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6-8 weeks
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SR1664
SR 1664
T233891338259-05-4In house
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity.
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K-111
K111, K 111, BM-170744, BM170744, BM 170744
T27706221564-97-2In house
K-111 (BM-170744) is an orally available peroxisome proliferator-activated receptor (PPAR)-alpha agonist and insulin enhancer for the study of obesity-type diabetes mellitus and the metabolic syndrome.
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6-8 weeks
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Suksdorfin
T6914653023-17-9In house
Suksdorfin has hypoglycemic effects, promotes adipocyte differentiation and enhances lipocalin production, activates peroxisome proliferator-activated receptor gamma (PPARγ), promotes insulin-dependent glucose uptake by adipocytes, and can be used to study obesity.
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6-8 weeks
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Clofibric acid
Chlorofibrinic acid
T0061882-09-7
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
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Pioglitazone hydrochloride
U-72107E, U 72107A, Pioglitazone HCl, AD 4833
T0214L112529-15-4
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
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Gliquidone
Glurenorm, AR-DF 26
T037133342-05-1
Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity, exhibiting greater binding affinity to SUR1 and increased potency compared to first-generation compounds. Additionally, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity.
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Bezafibrate
BM15075
T084141859-67-0
Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
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Retinoic acid
Vitamin A acid, Tretinoin, ATRA, all-trans-Retinoic acid
T1051302-79-4
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα β γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.
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Fenofibrate
Procetofen, Lipantil, Lipanthyl
T114949562-28-9
Fenofibrate (Lipanthyl) is a PPARα agonist (EC50=30 μM) and is selective. Fenofibrate also inhibits cytochrome P450 isoforms, such as CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4. Fenofibrate exhibits antihyperlipidemic activity.
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Daidzein
Isoflavone
T1238486-66-8
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
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Ciprofibrate
Win35833
T126452214-84-3
Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity.
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Fenofibric acid
Trilipix, FNF acid, NSC 281318
T140242017-89-0
Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
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Gemfibrozil
CI-719, Jezil, Decrelip, Lopid
T141525812-30-0
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).
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β-Carotene
Carotaben, Beta-Carotene, Provitamin A
T16337235-40-7
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene inhibits free-radical damage to DNA.
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