pp 5

PP5-IN-1 is a potent and competitive serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.

Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest. Ro 90-7501 also exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.

Perfluorodecalin (PFD) is a chemically and biologically inert biomaterial, hydrophobic and radiolucent, used as artificial blood. Perfluorodecalin enhances bone regeneration and cell viability.

Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer.

PP5-IN-2, a selective and orally active inhibitor of protein phosphatase 5 (PP5), exhibits an IC 50 of 0.9 μM. This compound activates p53 and leads to the downregulation of cyclin D1 and MGMT, thereby inducing cell cycle arrest and reversing Temozolomide (TMZ) resistance in the U87 MG cell line. Additionally, PP5-IN-2 has demonstrated effective inhibition of tumor growth in the xenograft mouse model.

1-PP-myo-InsP5 is a type of inositol pyrophosphate. In mammals, it functions as a signaling molecule by interacting with specific receptors or through non-enzymatic phosphate transfer. Additionally, 1-PP-myo-InsP5 is involved in various biological processes, such as insulin signaling and the regulation of telomere length.

Mavodelpar free acid hydrochloride (Pparδ agonist HCl) is a potent PPARδ agonist.

PP58 is an inhibitor of PDGFR, FGFR and Src family.

Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, moths, snout beetles and Ephestia cautella during storage of agricultural grains.

Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.

Okadaic acid ammonium salt is a marine toxin that acts as an inhibitor of protein phosphatases (PP), with the highest affinity for PP2A (IC50 = 0.1–0.3 nM), while also inhibiting PP1, PP3, PP4, and PP5, but not PP2C. By increasing the phosphorylation of various proteins, it functions as a tumor promoter and induces tau protein phosphorylation, commonly used to establish Alzheimer's disease models.

Mavodelpar (REN001), a selective PPARδ agonist, effectively suppresses glomerular injury and renal fibrosis. It is utilized in the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation disorders (LC-FAOD).

SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) is enzyme inhibition, antiproliferative effects and antifungal activity.

IRF5-CPP5 is a cell-penetrating peptide that targets homodimerization, selectively inhibiting human IRF5 with IC50 values of 15.4 μM for the recombinant S430D and 15.3 μM for the wild-type (WT) IRF5 monomer dimerization.

Hydroxy-PP is a powerful inhibitor of CBR1, exhibiting an IC50 value of 0.78 μM, and also strongly inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM [1].