ng 2

NG2 binding peptide is a specific short peptide that recognizes the NG2 proteoglycan and can be obtained via phage display technology. This peptide achieves precise targeting of tumor neovasculature in vitro and in vivo through interaction with NG2 binding sites. It demonstrates significant homing ability in wild-type tumor-bearing mice but shows no localization effect in NG2 knockout mice. Due to the tissue-specific expression of NG2, the NG2 binding peptide can be applied in tumor-targeted therapy, drug delivery, and molecular imaging diagnostics.

Adipiplon(NG2-73, NG273) is a novel selective gamma-aminobutyric acid (GABA) partial agonist.

NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively, in Gen2.2 cells in a concentration-dependent manner.2NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.3It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12Dmouse orthotopic model of colorectal cancer. 1.Tan, L., Nomanbhoy, T., Gurbani, D., et al.Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)J. Med. Chem.58(1)183-196(2015) 2.Pauls, E., Shpiro, N., Peggie, M., et al.Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cellsJ. Biol. Chem. 287(23)19216-19228(2012) 3.Ma, Q., Gu, L., Liao, S., et al.NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivoApoptosis24(1-2)83-94(2019)

Aflatoxin G2 is a major naturally occurring mycotoxin produced by the fungi [Aspergillus flavus] and [Aspergillus parasiticus].

CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.

NG25 is a potent dual inhibitor of TAK1 and MAP4K2, with IC50s of 149 nM and 21.7 nM, respectively.

NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner. It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.

TNG260 is a CoREST-selective deacetylase ( CoreDAC ) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3 . TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing .

Prostaglandin G2 (PGG2) serves as the initial stable intermediate in the COX pathway, identifiable and characterizable due to its stability. This compound is identified as the C-15 hydroperoxide derivative of PGH2. Typically, PGG2 undergoes rapid metabolism via the inherent peroxidase activity of both COX-1 and COX-2 enzymes, resulting in the production of PGH2. PGH2 is crucial as it is the primary precursor for the generation of 2-series prostaglandins and thromboxanes.

Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand

Cross-linked dextran G 200 is a hydrophilic gel designed for the separation of macromolecules based on molecular size exclusion. It operates through a gel permeation mechanism; its cross-linked structure forms a three-dimensional network with specific pore sizes, facilitating separation according to the hydrodynamic volume of molecules. This compound is utilized to regulate the partition coefficient of permeating solutes and maintain osmotic balance, and is commonly applied in gel filtration chromatography for the purification and analysis of biomacromolecules like proteins and nucleic acids. Additionally, Cross-linked dextran G 200 serves as a gel filtration medium (particle size range: 40-120 μm; spherical protein separation range: 5k-600k Da).

Cross-linked dextran G 25, coarse is a microsphere with an average particle size D50 of 200-250 μm.

Cross-linked dextran G 25, medium are microspheres with an average particle size D50 of 120-140 μm.

Cross-linked dextran G 25, fine is a microsphere with an average particle size D50 of 70-90 μm.

Licoricesaponin G2 (Standard) is a reference standard for research and analysis in studies involving Licoricesaponin G2. Licoricesaponin G2 is a pentacyclic triterpenoid derived from Glycyrrhiza aspera, which can be used to differentiate crude liquorice from honey-processed liquorice.

Monamycin G2 is an ester peptide antibiotic known for its activity against Gram-positive bacteria.

Luminacin G2 exhibits potent inhibitory effects on capillary formation (IC50 < 0.1 μg/mL).

Licoricesaponin G2, a pentacyclic triterpenoid derived from Glycyrrhiza aspera, can be used to differentiate crude liquorice from honey-processed liquorice.

Human Immunoglobulin G2 (Human IgG2) is a subclass of human IgG antibodies. An IgG2 deficiency can result in a diminished antibody response to bacterial polysaccharides, potentially increasing vulnerability to infections from encapsulated bacteria.

BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline that binds to the 30S ribosomal subunit, disrupting the binding of aminoacyl-tRNA to the mRNA-ribosome complex.

KRN7000 analog 3 (Compound 14), an α-GalCer analog featuring a 4-phenoxy substituent, acts as an iNKT agonist. This compound induces higher levels of IL-2 cytokine secretion in mNK1.2 cells (ranging from 49.2 to 62.6 ng/mL) compared to α-GalCer (44.1 ng/mL). KRN7000 analog 3 shows potential for research in anti-tumor agents and vaccine adjuvants.

NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.

Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.