mutations — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36287	Pirtobrutinib		BTK
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t...		BTK
T5469	K-Ras-IN-1		Raf , Ras
	K-Ras-IN-1 is a K-Ras inhibitor.		Raf , Ras
T9689	M4205		c-Kit
	M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.		c-Kit
T22318	Taletrectinib	DS-6051b,AB-106	Trk receptor , ROS , ROS Kinase
	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.		Trk receptor , ROS , ROS Kinase
T2680	NVP-BVU972		c-Met/HGFR
	NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.		c-Met/HGFR
T6311	Bafetinib	NS-187,INNO-406	Bcr-Abl , Src , Autophagy
	Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.		Bcr-Abl , Src , Autophagy
T4473	Ibiglustat	Venglustat,SAR402671,GZ402671	Transferase
	Ibiglustat (GZ402671) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthe...		Transferase
T5462	Almonertinib	HS-10296	EGFR
	Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.		EGFR
T0975	Chlorambucil	CB-1348,Chloroambucil,WR-139013	DNA Alkylator/Crosslinker , DNA Alkylation
	Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...		DNA Alkylator/Crosslinker , DNA Alkylation
T5675	Almonertinib hydrochloride	HS-10296 hydrochloride	EGFR
	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.		EGFR
T3709	XMD8-87	ACK1-B19	Tyrosinase , PPAR
	XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.		Tyrosinase , PPAR
T3630	Relugolix	RVT-601,TAK-385	GNRH Receptor
	Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi...		GNRH Receptor
T31425	Dibenz[a,h]anthracene	CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A	DNA
	Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.		DNA
T67839	HG106		Others
	HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases...		Others
T33296	Merodantoin		Apoptosis
	Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin targets cancer cells expressing KRAS mutations involved in Akt-dependent ROS production.		Apoptosis
T9754	BLU-945	BLU945,BLU 945	EGFR
	BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797...		EGFR
T7175	Alflutinib mesylate	AST2818 mesylate	EGFR
	Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.		EGFR
T15551	IDH889		Dehydrogenase
	IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).		Dehydrogenase
T8006	Oncrasin-1		Apoptosis , Raf , Ras
	Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations		Apoptosis , Raf , Ras
T22254	Alflutinib	AST2818,ASK120067	EGFR , P450
	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.		EGFR , P450