id 1

AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER, with CAS No. 159749-28-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Eupomatenoid 12 is a useful organic compound for research related to life sciences. The catalog number is T124879 and the CAS number is 41365-37-1.

Locked nucleic acid 1 is an LNA-type nucleoside derivative.

SID 125240931 is a regulator of fluorine-activated proteins (FAPs). This compound disrupts the binding between fluoride and FAPs.

Lipid 16 is an ionizable lipid that facilitates the synthesis of lipid nanoparticles (LNP) for the delivery of mRNA and other payloads. It specifically targets the CD11bhi macrophage population as a potent cell-type specific ionizable lipid, eliminating the need for additional targeting components.

Hexa lipid 114 is an ionizable cationic lipid and a derivative of lipid 114.

L-Aspartic acid 13C is a 13C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM) that possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2].

CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.

CID 1375606 is a surrogate agonist of the orphan G protein-coupled receptor [GPR27], characterized by a high level of conservation among vertebrates and predominant expression in the central nervous system.

Lipid 14, a potent ionizable compound, is essential for synthesizing lipid nanoparticles (LNPs) [1].

Amyloid 17-42 (Aβ(17-42)), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from alpha- and gamma-secretase cleavage of amyloid precursor protein (APP) and can trigger neuronal apoptosis via the Fas-like caspase-8 activation pathway [1].

Enterocin Hybrid 1, an antibacterial agent, effectively inhibits Vancomycin-resistant Enterococcus faecium and Staphylococcus haemolyticus [1].

Lipid 10, an ionizable amino lipid, is utilized in the production of Lipid nanoparticles (LNPs).

Lipid 15, an ionizable amino lipid, is utilized in the production of Lipid Nanoparticles (LNPs).

Lipid 1 is an ionizable aminolipid used in the synthesis of lipid nanoparticles.

Lipid 11 (Compound Lipid 1) is a cationic lipid designed for nucleic acid delivery. It forms lipid nanoparticles (LNPs) through electrostatic interactions with nucleic acids, such as ceDNA. By using its cationic amine groups, Lipid 11 complexes with negatively charged nucleic acids, enabling cellular uptake and release of the nucleic acid cargo. Lipid 11 shows potential for use in the development of gene therapy drug delivery systems.

β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation.

β-Amyloid 15-21 acetate (Beta-Amyloid (15-21) acetate) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation.

β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.

SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis.

Melanoma is a lethal skin cancer. The early detection of melanoma using positron emission tomography (PET) probes is critical for improving the survival of melanoma patients. Melanin probe-2 is a non-radioactive bromo-picolinamide precursor that has been used for the synthesis of18F-picolinamides based PET probe (melanin probe-1). The tumor-targeting efficacy and imaging property of three melanin probes were evaluated in B16F10 tumor-bearing mice.18F-1 and18F-3 had much lower tumor uptake compared with18F-2 (Melanin probe-2), which were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID g at 0.5, 1, and 2 h, respectively[1].

Edratide (TV 4710), a 19-amino-acid synthetic peptide derived from the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that exhibits the 16 6 Id idiotype, has been found to lower apoptosis rates and regulate the expression of caspase-8 and caspase-3 downward, while increasing Bcl-xL expression. It shows promise for systemic lupus erythematosus (SLE) research [1] [2] [3].

Grisnilimab setaritox (WT1-RTA), an anti-CD7 antihuman T cell antibody linked to ricin A chain (RTA), exhibits in vitro cytotoxicity against CEM (T-lymphoblastic leukemia) cells with an ID 50 of 53 pM. The 30-kDa RTA component disrupts the function of 60S ribosomal subunits. Additionally, Grisnilimab setaritox has demonstrated efficacy in ameliorating leukemic meningitis in a rhesus monkey model [1].